Janos Zempleni, Krishnamurti Dakshinamurti
Cell signaling is at the core of most biological processes from the simplest to the most complex. In addition to unicellular organisms possessing the essential ability to receive inputs with regard to nutrient availability and noxious stimuli, the cells in multicellular organisms require signaling from adjacent, as well as distant cells to maintain normal internal function, including growth, differentiation, and homeostasis. Conversely, the etiology of many disease processes, such as those involving immune system dysfunction and tumor development, have been traced to aberrant cell signaling.
Nutrients and Cell Signaling, in presenting contributions from a wide array of experts in the field, fully delineates the role of nutrients in cell signaling. The text emphasizes broad concepts and covers all major groups of nutrients. Contributors discuss the role of carbohydrates, amino acids, lipids, vitamins, minerals, and trace elements in essential processes such as cell proliferation, immune function, and DNA repair.
The editors have organized the work to provide select examples organized under these contemporary research areas:
Nuclear receptors, tranillegalscription factors, and signaling cascades
Amino acids, lipids, and glycation
Insulin release, signaling, and insulin resistance
Calcium-dependent signaling
Feeding and nutrient homeostasis
Nutrients and Cell Signaling answers the need in the post-genomic era, for an authoritative resource that provides an in-depth understanding of how these complex and dynamic biomolecular networks control cell function. Those professionals and students in molecular biology, nutrition, biochemistry, as well as any branch involved with cell signaling and function will find this book to be an invaluable tool in promoting both understanding and further inquiry.
Nuclear receptors, tranillegalscription factors, and signaling cascades. Amino acids, lipids, and glycation. Insulin release, signaling, and insulin resistance. Calcium-dependent signaling. Feeding and nutrient homeostasis.
While cell signaling has been a major focus of molecular biology for more than 30 years, only recently have the direct roles of nutrients in cell signaling received the proper recognition. This book provides a comprehensive review of the roles of nutrients in cell signaling. Leading experts in nutrient-dependent cell signaling discuss a broad range of topics and include select examples from an array of areas. These examples describe nuclear receptors, tranillegalscription factors, and signaling cascades; nitric oxide; chromatin structure; amino acids, lipids, and glycation; calcium dependent signaling; feeding and nutrient homeostasis; and more.
Inhaltsverzeichnis
Nuclear receptors, tranillegalscription factors, and signaling cascades NFkB-dependent signaling pathways, Xiaoxia Li Steroid receptors and dietary ligands, M.N. Jacobs Retinoid signaling, Dianne R. Soprano, Pu Qin, Kenneth J. Soprano Regulation of cytokines and immune function by 1,25-dihydroxyvitamn D3 and its analogues, Evelyne van Etten, Annapaula Giuletti, Conny Gysemans, Annemieke Verstuyf, Lut Overbergh, and Chantal Mathieu Vitamin D regulated pathways: impact on cell proliferation, differentiation, and apoptosis, JoEllen Welsh Effects of nutrient deprivation on the expression of growth-arrest genes, W.D. Rees Mechanisms for dietary regulation of nitric oxide synthesis in mammals, Nick E. Flynn, Cynthia J. Meininger, Tony E. Haynes, Wenjuan Shi, and Guoyao Wu The roles of thioredoxin reductases in cell signaling, Dan Su and Vadim N. Gladyshev Roles for biotinylation of histones in chromatin structure, Gabriela Camporeale, Nagarama Kothapalli, Gautam Sarath, and Janos Zempleni Amino acids, lipids, and glycation Nutrient signaling to muscle and adipose tissue by leucine, Thomas C. Vary and Christopher J. Lynch Anabolic effects of amino acids and insulin in the liver, Luc Bertrand and Louis Hue Amino acid-sensing of mTOR signaling, Ebru Erbay, Jae Eun Kim, Jie Chen Alterations in glutamate trafficking and signal transduction pathways in hyperammonemia, Helen Chan and Roger F. Butterworth The influence of lipids on nuclear protein import, cell growth and gene expression, Randolph S. Faustino, Melanie N. Landry, Nicole T. Gavel, Michael P. Czubryt, and Grant N. Pierce Isoprenoid regulation of the expression of RAS and RAS-related proteins, Sarah Holstein and Raymond J. Hohl Amino acid signaling and the control of autophagy, Alfred J. Meijer, Peter F. Dubbelhuis, Edward F. C. Blommaart, and P. Codogno A nutrient-sensing hexosamine signaling pathway, Dona Love and John A. Hanover Insulin release, signaling, and insulin resistance Insulin release, Mitsuhisa Komatsu Metabolic actions of the glucagon-like peptides, Rhonda D. Wideman and Timothy J. Kieffer Calcium-dependent signaling Control of intracellular calcium levels, Shyamala Dakshinamurti, Jonathan Geiger, and Krishnamurti Dakshinamurti Calcium-mediated signaling of neurons in the physiological and diseased state: role of endoplasmic reticulum, W. Paschen Feeding and nutrient homeostasis Within-meal feedback signaling, Jason C. G. Halford The arcuate nucleus: its special place in the brain networks that control feeding behavior, Bernard Beck
Klappentext
While cell signaling has been a major focus of molecular biology for more than 30 years, only recently have the direct roles of nutrients in cell signaling received the proper recognition. This book provides a comprehensive review of the roles of nutrients in cell signaling. Leading experts in nutrient-dependent cell signaling discuss a broad range of topics and include select examples from an array of areas. These examples describe nuclear receptors, tranillegalscription factors, and signaling cascades; nitric oxide; chromatin structure; amino acids, lipids, and glycation; calcium dependent signaling; feeding and nutrient homeostasis; and more.
