Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined. |This book provides a general background as well as an overview and update of the use of cancer immunotherapy. Aside from highlighting new advances and directions in cancer immunotherapy; also covered are the most common forms of cancer immunotherapy, challenges in clinical trial design and the need for biomarkers of response.
Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches Özlem Türeci, Thorsten Klamp, Michael Koslowski, Sebastian Kreiter, and Ugur Sahin Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens Ludmila Müller, Stephanie McArdle, Evelyna Derhovanessian, Thomas Flad, Ashley Knights, Robert Rees, and Graham Pawelec Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy Lisa M. Harlan and Julie Y. Djeu The Role of Immune Monitoring in Evaluating Cancer Immunotherapy Holden T. Maecker Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials Susan Groshen DNA Vaccines for Cancer Immunotherapy Heesun Kwak and Howard L. Kaufman Dendritic Cells Weiping Zou and Tyler J. Curiel Different Approaches to Dendritic Cell-Based Cancer Immunotherapy Noweeda Mirza and Dmitry Gabrilovich Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer Malaya Bhattacharya-Chatterjee, Nitin Rohatgi, Sunil K. Chatterjee, Asim Saha, Rakesh Shukla, and Kenneth A. Foon Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics Jie Dai and Zihai Li Tumor-Reactive T-Cells for Adoptive Immunotherapy Helga Bernhard, Julia Neudorfer, Kerstin Gebhard, Heinke Conrad, Dirk H. Busch, and Christian Peschel T-Cell Adoptive Immunotherapy of Cancer: From Translational Models to Clinical Significance Peter A. Cohen, Mohamed Awad, and Suyu Shu Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells Jeffrey J. Roszkowski and Michael I. Nishimura Harnessing the Potential of Graft-vs-Tumor Nancy M. Hardy and Michael R. Bishop Tumor-Induced Immune Suppression and Immune Escape: Mechanisms and Impact on the Outcome ofImmunotherapy of Malignant Disease Michael Campoli and Soldano Ferrone The Tumor Microenvironment: Regulation of Antitumor Immunity and Implications for Immunotherapy George Coukos and Jose-Ramon Conejo-Garcia Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity Eduardo Davila and Esteban Celis Fast-Lane Evolution in the Tumor Microenvironment Gabriella Marincola and Francesco M. Marincola Manipulating Immunological Checkpoints to Maximize Antitumor Immunity Leisha A. Emens, R. Todd Reilly, and Elizabeth M. Jaffee Interleukin-2 as Cancer Therapy Joseph I. Clark and Kim A. Margolin Biological and Clinical Properties of the Type 1 Interferons Douglas W. Leaman, Shaun Rosebeck, and Ernest C. Borden Promising g-Chain Cytokines for Cancer Immunotherapy: Interleukins-7, -15, and -21 as Vaccine Adjuvants, Growth Factors and Immunorestoratives Terry J. Fry and Crystal L. Mackall The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies Sherif S. Farag and Michael A. Caligiuri Antibody Therapy for Solid Tumors Cristina I. Truica, Dorinda Rouch, and Carlos L. Arteaga Antibody Therapy for Non-Hodgkin's Lymphoma Stephen M. Ansell and Thomas E. Witzig Approaches to In Vivo Imaging of Cancer Immunotherapy George A. Vielhauer, Bond Almand, Mary L. Disis, David A. Mankoff, and Keith L. Knutson Design Issues for Early-Stage Clinical Trials for Cancer Vaccines Gina R. Petroni Monoclonal Antibody Therapy of Cancer Hossein Borghaei, Matthew K. Robinson, and Louis M. Weiner Index
Major scientific advances in molecular and clinical immunology have produced tremendous growth in our understanding of how cancer is recognized by the immune system, as well as in our ability to control and modulate that recognition. In Immunotherapy of Cancer, expert bench and clinical scientists join forces to concurrently review both the state of the art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T-cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunological monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
Comprehensive and cutting-edge, Immunotherapy of Cancer offers immunologists an exhaustive and authoritative survey of cancer immunotherapy, as well as providing a springboard for applying the most important findings in tumor immunology to any basic laboratory program or clinical oncology practice.
From the reviews:
"Immunotherapy of Cancer provides in 28 chapters a comprehensive overview of experimental and clinical achievements in tumor immunology. Each chapter is designed to give the reader the scientific basis behind the discussed therapy and outline basic theory, as well as practical treatment applications. ... The book belongs to the successful series of publications Cancer Drug Discovery and Development from Humana Press. It will be of interest to clinicians and to laboratory cancer researchers ... ." (Cestmir Altaner, Neoplasma, Vol. 54 (2), March, 2007)
Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches.- Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens.- Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy.- The Role of Immune Monitoring in Evaluating Cancer Immunotherapy.- Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials.- DNA Vaccines for Cancer Immunotherapy.- Dendritic Cells.- Different Approaches to Dendritic Cell-Based Cancer Immunotherapy.- Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer.- Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics.- Tumor-Reactive T-Cells for Adoptive Immunotherapy.- T-Cell Adoptive Immunotherapy of Cancer.- Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells.- Harnessing the Potential of Graft-vs-Tumor.- Tumor-Induced Immune Suppression and Immune Escape.- The Tumor Microenvironment.- Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity.- Fast-Lane Evolution in the Tumor Microenvironment.- Manipulating Immunological Checkpoints to Maximize Antitumor Immunity.- Interleukin-2 as Cancer Therapy.- Biological and Clinical Properties of the Type 1 Interferons.- Promising ?-Chain Cytokines for Cancer Immunotherapy.- The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies.- Antibody Therapy for Solid Tumors.- Antibody Therapy for Non-Hodgkin's Lymphoma.- Approaches to In Vivo Imaging of Cancer Immunotherapy.- Design Issues for Early-Stage Clinical Trials for Cancer Vaccines.- Monoclonal Antibody Therapy of Cancer.
From the reviews:
"Immunotherapy of Cancer provides in 28 chapters a comprehensive overview of experimental and clinical achievements in tumor immunology. Each chapter is designed to give the reader the scientific basis behind the discussed therapy and outline basic theory, as well as practical treatment applications. ... The book belongs to the successful series of publications Cancer Drug Discovery and Development from Humana Press. It will be of interest to clinicians and to laboratory cancer researchers ... ." (Cestmir Altaner, Neoplasma, Vol. 54 (2), March, 2007)
Inhaltsverzeichnis
Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches
Özlem Türeci, Thorsten Klamp, Michael Koslowski, Sebastian Kreiter, and Ugur Sahin
Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens
Ludmila Müller, Stephanie McArdle, Evelyna Derhovanessian, Thomas Flad, Ashley Knights, Robert Rees, and Graham Pawelec
Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy
Lisa M. Harlan and Julie Y. Djeu
The Role of Immune Monitoring in Evaluating Cancer Immunotherapy
Holden T. Maecker
Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials
Susan Groshen
DNA Vaccines for Cancer Immunotherapy
Heesun Kwak and Howard L. Kaufman
Dendritic Cells
Weiping Zou and Tyler J. Curiel
Different Approaches to Dendritic Cell-Based Cancer Immunotherapy
Noweeda Mirza and Dmitry Gabrilovich
Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer
Malaya Bhattacharya-Chatterjee, Nitin Rohatgi, Sunil K. Chatterjee, Asim Saha, Rakesh Shukla, and Kenneth A. Foon
Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics
Jie Dai and Zihai Li
Tumor-Reactive T-Cells for Adoptive Immunotherapy
Helga Bernhard, Julia Neudorfer, Kerstin Gebhard, Heinke Conrad, Dirk H. Busch, and Christian Peschel
T-Cell Adoptive Immunotherapy of Cancer: From Translational Models to Clinical Significance
Peter A. Cohen, Mohamed Awad, and Suyu Shu
Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells
Jeffrey J. Roszkowski and Michael I. Nishimura
Harnessing the Potential of Graft-vs-Tumor
Nancy M. Hardy and Michael R. Bishop
Tumor-Induced Immune Suppression and Immune Escape: Mechanisms and Impact on the Outcome ofImmunotherapy of Malignant Disease
Michael Campoli and Soldano Ferrone
The Tumor Microenvironment: Regulation of Antitumor Immunity and Implications for Immunotherapy
George Coukos and Jose-Ramon Conejo-Garcia
Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity
Eduardo Davila and Esteban Celis
Fast-Lane Evolution in the Tumor Microenvironment
Gabriella Marincola and Francesco M. Marincola
Manipulating Immunological Checkpoints to Maximize Antitumor Immunity
Leisha A. Emens, R. Todd Reilly, and Elizabeth M. Jaffee
Interleukin-2 as Cancer Therapy
Joseph I. Clark and Kim A. Margolin
Biological and Clinical Properties of the Type 1 Interferons
Douglas W. Leaman, Shaun Rosebeck, and Ernest C. Borden
Promising g-Chain Cytokines for Cancer Immunotherapy: Interleukins-7, -15, and -21 as Vaccine Adjuvants, Growth Factors and Immunorestoratives
Terry J. Fry and Crystal L. Mackall
The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies
Sherif S. Farag and Michael A. Caligiuri
Antibody Therapy for Solid Tumors
Cristina I. Truica, Dorinda Rouch, and Carlos L. Arteaga
Antibody Therapy for Non-Hodgkin's Lymphoma
Stephen M. Ansell and Thomas E. Witzig
Approaches to In Vivo Imaging of Cancer Immunotherapy
George A. Vielhauer, Bond Almand, Mary L. Disis, David A. Mankoff, and Keith L. Knutson
Design Issues for Early-Stage Clinical Trials for Cancer Vaccines
Gina R. Petroni
Monoclonal Antibody Therapy of Cancer
Hossein Borghaei, Matthew K. Robinson, and Louis M. Weiner
Index
Klappentext
Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
This book provides a general background as well as an overview and update of the use of cancer immunotherapy. Aside from highlighting new advances and directions in cancer immunotherapy; also covered are the most common forms of cancer immunotherapy, challenges in clinical trial design and the need for biomarkers of response.
