Alan M Moses is currently Associate Professor and Canada Research Chair in Computational Biology in the Departments of Cell & Systems Biology and Computer Science at the University of Toronto. His research touches on many of the major areas in computational biology, including DNA and protein sequence analysis, phylogenetic models, population genetics, expression profiles, regulatory network simulations and image analysis.
Molecular biologists are performing increasingly large and complicated experiments, but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts in data analysis using a wide variety of real-world molecular biological examples such as eQTLs, ortholog identification, motif finding, inference of population structure, protein fold prediction and many more. The book takes a pragmatic approach, focusing on techniques that are based on elegant mathematics yet are the simplest to explain to scientists with little background in computers and statistics.
Introduction. Statistical modeling. Statistics and probability. Multiple testing. Multivariate statistics and parameter estimation. Clustering. Distance-based. Gaussian mixture models. Simple linear regression. Multiple regression and generalized linear models. Regularization. Linear classification. Non-linear classification. Evaluating classifiers and ensemble methods. Correlated data in one dimension. Hidden-Markov models. Local regression.
'Urban Design: Health and the Therapeutic Environment' demonstrates how urban design and planning impact on public health and sustainable development. Moughtin et al. explore the concept of what makes a physically and psychologically ?healthy? environment in the context of the paramount need for new homes where living standards are not compromised, in increasingly crowded cities. ? Sets out the history and development of the healthy city, from the English spa town to standards of care in Cuba to provide a context for modern urban health development. ? Covers a wide range of environmental, ecological, health and epidemiological issues. ? Case studies and examples show how health policy and procedure is practically applied to sustainable urban development. 'Urban Design: Health and the Therapeutic Environment' outlines best practice for healthy, sustainable urban design and provides a reference tool for architects, urban designers, landscape architects, health professionals and planners. Emeritus Professor Cliff Moughtin was Professor of Planning in The Queen?s University Belfast and The University of Nottingham. He is author of a number of books including the series of five Urban Design titles for Architectural Press. Kate McMahon Moughtin is a psychotherapist. She is author of Focused Therapy for Organisations and Individuals. She is interested in how literature and environmental infl uences contribute to wellbeing. Paola Signoretta is a human geographer. She is a senior research associate in the Centre for Research in Social Policy, Loughborough University. She is interested in the geographies of health, deprivation and social and financial exclusion.
