Joseph G. Sinkovics , Joseph C. Horvath
Featuring contributions from nearly 30 leading authorities, this pioneering work gauges the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers in humans-detailing the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses, and viral oncolysates as evidenced in basic and experimental studies.
Introduction o Progressive Development of the Viral Therapy of Human Cancers: A Personal Narrative Account Joseph G. Sinkovics o New Biological Therapeutics: Competitors or Collaborators in Viral Therapy for Human Cancers Joseph G. Sinkovics o Naturally Oncolytic Viruses o Measles Virus: Improving Natural Oncolytic Properties by Genetic Engineering Christoph Springfield, Adele Fielding, Kah-Whye Peng, Eva Galanis, Stephen J. Russell, and Roberto Cattaneo o Newcastle Disease Virus: Anti-tumor Immune Memory and Its Activation for Control of Residual Tumor Cells and Improvement of Patient Survival Volker Schirrmacher o Newcastle Disease Virus: Its Oncolytic Properties Joseph C. Horvath o Influenza A Viruses with Deletions in the NS1 Gene: A Rational Approach to Develop Oncolytic Viruses Michael Bergmann and Thomas Muster o Vesicular Stomatitis Virus: An Oncolytic Agent Rebecca A. C. Taylor, Jennifer M. Paterson, and John C. Bell o Parvoviruses as Anti-Cancer Agents Jean Rommelaere, Nathalia Giese, Celina Cziepluch, and Jan J. Cornelis o Viral Oncolysates o Newcastle Disease Virus Oncolysate in the Management of Stage III (AJCC) Malignant Melanoma William A. Cassel, Douglas R. Murray, and Zbigniew L. Olkowski o Vaccinia Viral Lysates in Immunotherapy of Melanoma Peter Hersey o Genetically Engineered Oncolytic Viruses o Fusogenic Oncolytic Herpes Simplex Viruses for Therapy of Solid Tumors Xinping Fu, Mikihito Nakamori, and Xiaoliu Zhang o Poliovirus Recombinants Against Malignant Glioma Melinda Merrill, David Solecki, and Matthias Gromeier o Oncolytic Viruses that Depend on Loss of RB or p53 Frank McCormick
Featuring contributions from leading authorities, this pioneering work explores the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers. It details the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses, and viral oncolysates as evidenced in basic and experimental studies and includes coverage of measles, influenza, and herpes simplex viruses; parvoviruses; poliovirus recombinants; Newcastle disease viruses and viral oncolysates; and vaccinia viral lysates. Comparing the viral therapy of cancer with alternative biological therapeutic approaches, the book lists more than fifty oncolytic adenovirus preparations.
Arrays the results of research on viral oncolysis. This book surveys possible research pathways for the treatment of human cancers and examines the regression of tumors in virally-infected patients, as well as controversies involved in viral oncolysis. It analyzes gene therapy and active specific immunotherapy of human tumors by viral vectors.
Inhaltsverzeichnis
Introduction o Progressive Development of the Viral Therapy of Human Cancers: A Personal Narrative Account Joseph G. Sinkovics o New Biological Therapeutics: Competitors or Collaborators in Viral Therapy for Human Cancers Joseph G. Sinkovics o Naturally Oncolytic Viruses o Measles Virus: Improving Natural Oncolytic Properties by Genetic Engineering Christoph Springfield, Adele Fielding, Kah-Whye Peng, Eva Galanis, Stephen J. Russell, and Roberto Cattaneo o Newcastle Disease Virus: Anti-tumor Immune Memory and Its Activation for Control of Residual Tumor Cells and Improvement of Patient Survival Volker Schirrmacher o Newcastle Disease Virus: Its Oncolytic Properties Joseph C. Horvath o Influenza A Viruses with Deletions in the NS1 Gene: A Rational Approach to Develop Oncolytic Viruses Michael Bergmann and Thomas Muster o Vesicular Stomatitis Virus: An Oncolytic Agent Rebecca A. C. Taylor, Jennifer M. Paterson, and John C. Bell o Parvoviruses as Anti-Cancer Agents Jean Rommelaere, Nathalia Giese, Celina Cziepluch, and Jan J. Cornelis o Viral Oncolysates o Newcastle Disease Virus Oncolysate in the Management of Stage III (AJCC) Malignant Melanoma William A. Cassel, Douglas R. Murray, and Zbigniew L. Olkowski o Vaccinia Viral Lysates in Immunotherapy of Melanoma Peter Hersey o Genetically Engineered Oncolytic Viruses o Fusogenic Oncolytic Herpes Simplex Viruses for Therapy of Solid Tumors Xinping Fu, Mikihito Nakamori, and Xiaoliu Zhang o Poliovirus Recombinants Against Malignant Glioma Melinda Merrill, David Solecki, and Matthias Gromeier o Oncolytic Viruses that Depend on Loss of RB or p53 Frank McCormick
Klappentext
Arrays the results of research on viral oncolysis. This book surveys possible research pathways for the treatment of human cancers and examines the regression of tumors in virally-infected patients, as well as controversies involved in viral oncolysis. It analyzes gene therapy and active specific immunotherapy of human tumors by viral vectors.
