Provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders.
This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.
The Reelin Gene and Its Functions in Brain DevelopmentCheng-Chiu Huang, MSGabriella D´Arcangelo, PhD*Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An OverviewDr. Hans H. Bock*Prof. Dr. Joachim HerzChemistry of ReelinYves Jossin, PhD*The C-terminal region of Reelin: structure and functionMitsuharu Hattori, PhD*Crystal Structure of Reelin RepeatsJunichi Takagi, PhD*Comparative Anatomy and Evolutionary Roles of ReelinGundela Meyer, MD, PhD*Reelin / Dab1 Signaling in the Developing Cerebral CortexEric C. Olson, PhD*Christopher A. Walsh, MD, PhDUltrastructural Localization of Reelin Rosalinda C. Roberts, PhD*Emma Perez-Costas, PhDReelin and Cyclin-Dependent Kinase 5Toshio Ohshima, MD, PhD*Reelin and the CerebellumRobert F. Hevner, MD, PhD*Reelin and Radial Glial CellsEckart Forster, PhDShanting Zhao, MDMichael Frotscher, MD*Reelin and CognitionShenfeng Qiu, PhDEdwin John Weeber, PhD*Protein Kinases and Signaling Pathways that are Activated by ReelinJonathan A. Cooper, PhD*Nathaniel S. Allen, BSLibing Feng, PhDThe Relationship of Oxytocin and Reelin in the BrainGeorge D. Pappas, PhD*C. Sue Carter, PhDReelin and Thyroid HormoneManuel Alvarez-Dolado, PhD*A Tale of Two Genes: Reelin and BDNFThomas Ringstedt, PhD*Reelin, Liver, and LymphaticsBrigitteSamama, PhD*Nelly Boehm, MD, PhDReelin and Cajal-Retzius CellsJean-Marc Mienville, PhD*Reelin and OdontogenesisFrancoise Bleicher*Henry MagloireMarie-Lise CoubleJean-Christophe MaurinHomozygous and Heterozygous Reeler Mouse MutantsPatricia Tueting, PhD*Graziano Pinna, PhDErminio Costa, MDReelin and LissencephalyElena Parrini, PhDRenzo Guerrini, MD*The Role of Reelin in Etiology and Treatment of Psychiatric DisordersS. Hossein Fatemi, MD, PhD*Teri J. Reutiman, BATimothy D. Folsom, MSReelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in SchizophreniaErminio Costa, MD*Ying Chen, PhDErbo Dong PhDDennis R. Grayson, PhDAlessandro Guidotti, MDMarin Veldic, MDEpigenetic Modulation of Reelin Function in Schizophrenia and Bipolar DisorderHamid Mostafavi Abdolmaleky, MD*Cassandra L. Smith PhDJin-Rong Zhou, PhDSam Thiagalingam, PhDReelin Gene Polymorphisms in Autistic DisorderCarla Lintas PhDAntonio Maria Persico, MD*Alzheimer´s and ReelinArancha Botella-Lopez, BSJavier Saez-Valero, PhD*Reelin and StrokeKunlin Jin, MD, PhD*Reelin and Pancreatic Cancer Kimberly Walter, BS Michael Goggins, MD*
Reelin glycoprotein is a major secretory protein with important roles in embryogenesis and during adult life. Reelin gene mutations or deficiency of the protein product cause abnormal cortical development and reelin signaling impairment in brain. Since the first discovery of the reelin mutant mouse in 1951 by Falconer, and later discovery of the gene for reelin in 1995, there has been an explosion of new knowledge about this important molecule. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease, written by an international panel of experts, summarizes the state of the knowledge on various aspects of reelin. Topics include the reelin gene and its receptors, downstream effector molecules in reelin signaling cascade, chemistry and structure of reelin, comparative anatomy of reelin, presence of reelin in various body tissues, reelin mutations, and abnormalities of reelin production in neuropsychiatric disorders and cancer. This book will serve as a foundation for analysis of this emerging novel protein for all neuroscientists and clinicians.
From the reviews:
"The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. ... The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. ... This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody´s Review Service, July, 2009)
"The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. ... The book consists of 28 chapters presented by international group of experts. ... book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders.” (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.
The Reelin Gene and Its Functions in Brain DevelopmentnCheng-Chiu Huang, MSnGabriella D'Arcangelo, PhD*nnnApolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An OverviewnnDr. Hans H. Bock*nProf. Dr. Joachim HerznnnChemistry of ReelinnnYves Jossin, PhD*nnnThe C-terminal region of Reelin: structure and functionnnMitsuharu Hattori, PhD*nnnCrystal Structure of Reelin RepeatsnnJunichi Takagi, PhD*nnnComparative Anatomy and Evolutionary Roles of ReelinnnGundela Meyer, MD, PhD*nnnReelin / Dab1 Signaling in the Developing Cerebral CortexnnEric C. Olson, PhD*nChristopher A. Walsh, MD, PhDnnnUltrastructural Localization of Reelin nnRosalinda C. Roberts, PhD*nEmma Perez-Costas, PhDnnnReelin and Cyclin-Dependent Kinase 5nnToshio Ohshima, MD, PhD*nnnReelin and the CerebellumnnRobert F. Hevner, MD, PhD*nnnReelin and Radial Glial CellsnnEckart Forster, PhDnShanting Zhao, MDnMichael Frotscher, MD*nnnReelin and CognitionnnShenfeng Qiu, PhDnEdwin John Weeber, PhD*nnnProtein Kinases and Signaling Pathways that are Activated by ReelinnnJonathan A. Cooper, PhD*nNathaniel S. Allen, BSnLibing Feng, PhDnnnThe Relationship of Oxytocin and Reelin in the BrainnnGeorge D. Pappas, PhD*nC. Sue Carter, PhDnnnReelin and Thyroid HormonennManuel Alvarez-Dolado, PhD*nnnA Tale of Two Genes: Reelin and BDNFnnThomas Ringstedt, PhD*nnnReelin, Liver, and LymphaticsnnBrigitteSamama, PhD*nNelly Boehm, MD, PhDnnnReelin and Cajal-Retzius CellsnnJean-Marc Mienville, PhD*nnnReelin and OdontogenesisnnFrancoise Bleicher*nHenry MagloirenMarie-Lise CoublenJean-Christophe MaurinnnnHomozygous and Heterozygous Reeler Mouse MutantsnnPatricia Tueting, PhD*nGraziano Pinna, PhDnErminio Costa, MDnnnReelin and LissencephalynnElena Parrini, PhDnRenzo Guerrini, MD*nnnThe Role of Reelin in Etiology and Treatment of Psychiatric DisordersnnS. Hossein Fatemi, MD, PhD*nTeri J. Reutiman, BAnTimothy D. Folsom, MSnnnReelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in SchizophreniannErminio Costa, MD*nYing Chen, PhDnErbo Dong PhDnDennis R. Grayson, PhDnAlessandro Guidotti, MDnMarin Veldic, MDnnnEpigenetic Modulation of Reelin Function in Schizophrenia and Bipolar DisordernnHamid Mostafavi Abdolmaleky, MD*nCassandra L. Smith PhDnJin-Rong Zhou, PhDnSam Thiagalingam, PhDnnnReelin Gene Polymorphisms in Autistic DisordernnCarla Lintas PhDnAntonio Maria Persico, MD*nnnAlzheimer's and ReelinnnArancha Botella-Lopez, BSnJavier Saez-Valero, PhD*nnnReelin and StrokennKunlin Jin, MD, PhD*nnnReelin and Pancreatic Cancern Kimberly Walter, BSn Michael Goggins, MD*
From the reviews:
"The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. ... The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. ... This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody's Review Service, July, 2009)
"The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. ... The book consists of 28 chapters presented by international group of experts. ... book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders." (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)
Inhaltsverzeichnis
The Reelin Gene and Its Functions in Brain Development
Cheng-Chiu Huang, MS
Gabriella D'Arcangelo, PhD*
Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An Overview
Dr. Hans H. Bock*
Prof. Dr. Joachim Herz
Chemistry of Reelin
Yves Jossin, PhD*
The C-terminal region of Reelin: structure and function
Mitsuharu Hattori, PhD*
Crystal Structure of Reelin Repeats
Junichi Takagi, PhD*
Comparative Anatomy and Evolutionary Roles of Reelin
Gundela Meyer, MD, PhD*
Reelin / Dab1 Signaling in the Developing Cerebral Cortex
Eric C. Olson, PhD*
Christopher A. Walsh, MD, PhD
Ultrastructural Localization of Reelin
Rosalinda C. Roberts, PhD*
Emma Perez-Costas, PhD
Reelin and Cyclin-Dependent Kinase 5
Toshio Ohshima, MD, PhD*
Reelin and the Cerebellum
Robert F. Hevner, MD, PhD*
Reelin and Radial Glial Cells
Eckart Forster, PhD
Shanting Zhao, MD
Michael Frotscher, MD*
Reelin and Cognition
Shenfeng Qiu, PhD
Edwin John Weeber, PhD*
Protein Kinases and Signaling Pathways that are Activated by Reelin
Jonathan A. Cooper, PhD*
Nathaniel S. Allen, BS
Libing Feng, PhD
The Relationship of Oxytocin and Reelin in the Brain
George D. Pappas, PhD*
C. Sue Carter, PhD
Reelin and Thyroid Hormone
Manuel Alvarez-Dolado, PhD*
A Tale of Two Genes: Reelin and BDNF
Thomas Ringstedt, PhD*
Reelin, Liver, and Lymphatics
BrigitteSamama, PhD*
Nelly Boehm, MD, PhD
Reelin and Cajal-Retzius Cells
Jean-Marc Mienville, PhD*
Reelin and Odontogenesis
Francoise Bleicher*
Henry Magloire
Marie-Lise Couble
Jean-Christophe Maurin
Homozygous and Heterozygous Reeler Mouse Mutants
Patricia Tueting, PhD*
Graziano Pinna, PhD
Erminio Costa, MD
Reelin and Lissencephaly
Elena Parrini, PhD
Renzo Guerrini, MD*
The Role of Reelin in Etiology and Treatment of Psychiatric Disorders
S. Hossein Fatemi, MD, PhD*
Teri J. Reutiman, BA
Timothy D. Folsom, MS
Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia
Erminio Costa, MD*
Ying Chen, PhD
Erbo Dong PhD
Dennis R. Grayson, PhD
Alessandro Guidotti, MD
Marin Veldic, MD
Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder
Hamid Mostafavi Abdolmaleky, MD*
Cassandra L. Smith PhD
Jin-Rong Zhou, PhD
Sam Thiagalingam, PhD
Reelin Gene Polymorphisms in Autistic Disorder
Carla Lintas PhD
Antonio Maria Persico, MD*
Alzheimer's and Reelin
Arancha Botella-Lopez, BS
Javier Saez-Valero, PhD*
Reelin and Stroke
Kunlin Jin, MD, PhD*
Reelin and Pancreatic Cancer
Kimberly Walter, BS
Michael Goggins, MD*
Klappentext
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.
Provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies
