With the advent of transgenic technology, which allows the identification of specific gene activities in developing mammalian organisms, the house mouse has once again taken a very important place in experimental research as one of the genetically best understood mammals. More than ever, molecular biologists are in need of a detailed, standardized deillegalscription of the anatomy of the developing mouse embryo. In this classic compendium, now brought up to date and corrected, the author presents each stage of mouse development in photographs and micrographs using hybrids of two inbred strains as a standard. Organ systems are systematically reconstructed from fertilization until after birth. Molecular biologists tracing the effects of genetic manipulations, as well as students and researchers of developmental biology, will appreciate the renewed availability of this standard reference work for its unparalleled accuracy, its attention to anatomical detail, and the extent of its documentation.
Contents: Introduction.- Materials and Methods.- Procedure.- One-Celled Egg (1-20 Hours).- Beginning of Segmentation (20-24 Hours).- Segmenting Egg (2 Days).- Advanced Segmentation (3 Days).- Blastocyst (4 Days).- Implantation (4 1/2 Days).- Formation of Egg Cylinder (5 Days).- Differentation of Egg Cylinder (6 Days).- Advanced Endometrial Reaction (6 1/2 Days).- Amnion (7 Days).- Neural Plate Presomite Stage (7 1/2 Days).- First Somites (8 Days).- Turning of the Embryo (8 1/2 Days).- Formation and Closure of Anterior Neuropore (9 Days).- Formation of Posterior Neuropore, Forelimb Bud (9 1/2 Days).- Closure of Posterior Neuropore, Hind Limb Bud and Tail Bud (10 Days).- Deep Lens Indentation (10 1/2 Days).- Closure of Lens Vesicle (11 Days).- Lens Vesicle Completely Separated from Surface (11 1/2 Days).- Earliest Sign of Fingers (12 Days).- Anterior Footplate Indented, Marked Pinna (13 Days).- Fingers Separate Distally (14 Days).- Toes Separate (15 Days).- Reposition of Umbical Hernia (16 Days).- Fingers and Toes Joined Together (17 Days).- Long Wiskers (18 Days).- Newborn Mouse (19 Days).- Postnatal Development.- Weight Curves.- Selected References.- Subject Index.
Inhaltsverzeichnis
Contents: Introduction.- Materials and Methods.- Procedure.- One-Celled Egg (1-20 Hours).- Beginning of Segmentation (20-24 Hours).- Segmenting Egg (2 Days).- Advanced Segmentation (3 Days).- Blastocyst (4 Days).- Implantation (4 1/2 Days).- Formation of Egg Cylinder (5 Days).- Differentation of Egg Cylinder (6 Days).- Advanced Endometrial Reaction (6 1/2 Days).- Amnion (7 Days).- Neural Plate Presomite Stage (7 1/2 Days).- First Somites (8 Days).- Turning of the Embryo (8 1/2 Days).- Formation and Closure of Anterior Neuropore (9 Days).- Formation of Posterior Neuropore, Forelimb Bud (9 1/2 Days).- Closure of Posterior Neuropore, Hind Limb Bud and Tail Bud (10 Days).- Deep Lens Indentation (10 1/2 Days).- Closure of Lens Vesicle (11 Days).- Lens Vesicle Completely Separated from Surface (11 1/2 Days).- Earliest Sign of Fingers (12 Days).- Anterior Footplate Indented, Marked Pinna (13 Days).- Fingers Separate Distally (14 Days).- Toes Separate (15 Days).- Reposition of Umbical Hernia (16 Days).- Fingers and Toes Joined Together (17 Days).- Long Wiskers (18 Days).- Newborn Mouse (19 Days).- Postnatal Development.- Weight Curves.- Selected References.- Subject Index.
Klappentext
With the advent of transgenic technology, which allows the identification of specific gene activities in developing mammalian organisms, the house mouse has once again taken a very important place in experimental research as one of the genetically best understood mammals. More than ever, molecular biologists are in need of a detailed, standardized deillegalscription of the anatomy of the developing mouse embryo. In this classic compendium, now brought up to date and corrected, the author presents each stage of mouse development in photographs and micrographs using hybrids of two inbred strains as a standard. Organ systems are systematically reconstructed from fertilization until after birth. Molecular biologists tracing the effects of genetic manipulations, as well as students and researchers of developmental biology, will appreciate the renewed availability of this standard reference work for its unparalleled accuracy, its attention to anatomical detail, and the extent of its documentation.
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