This book constitutes the strictly refereed post-workshop proceedings of the German Conference on Bioinformatics, GCB'96, held in Leipzig, Germany, in September/October 1996. The volume presents 18 revised full papers together with three invited papers; these contributions were selected after a second round of reviewing from the 91 conference presentations. The book addresses current issues in computational biology and biologically inspired computing. The papers are organized in sections on biological and metabolic pathways, sequence analysis, molecular modeling, visualization, and formal languages, and DNA.
Molecular computing: From conformational pattern recognition to complex processing networks.- A look at the visual modeling of plants using L-systems.- Bioinformatics and cheminformatics in the drug discovery cycle.- New developments in linking of biological databases and computer-generation of annotation: SWISS-PROT and its computer-annotated supplement TREMBL.- EpoDB: An erythropoiesis gene expression database in progress.- Recent advances in molecular distance geometry.- Three models of gene regulation in E. coli.- A new method to develop highly specific models for regulatory DNA regions.- Towards an object-oriented framework for the modeling of integrated metabolic processes.- TRRD and COMPEL databases on tranillegalscription linked to TRANSFACAS as tools for analysis and recognition of regulatory sequences.- Integrating heterogeneous datasets in genomic mapping: Radiation hybrids, YACs, genes and STS markers over the entire human chromosome X.- A clustering approach to Generalized Tree Alignment with application to Alu repeats.- Simple folding model for HP lattice proteins.- Fast protein fold recognition and accurate sequence-structure alignment.- Carbohydrates: Second-class citizens in biomedicine and in bioinformatics?.- Structural constraints and neutrality in RNA.- A systematic approach to finding new lead structures having biological activity.- Visualization and analysis of the complete yeast genome.- Virtual reality modeling for structural biology.- Evolutionary grammars: A grammatical model for genome evolution.- From DNA recombination to DNA computing via formal languages.
Thomas Lengauer, born 1952, studied Mathematics and Informatics at Berlin and Stanford. After a brief stay at the Bell Laboratories, he held various academic positions at the universities of Saarbruecken, Paderborn, and Bonn. From 1992 to 2001, he headed the Institue for Algorithms and Scientific Computing at the GBM in Sankt Augustin (Germany). Since 2001, he is director at the Max-Planck-Institute for Informatics in Saarbruecken (Germany).Professor Lengauer has recently been awarded the Konrad-Zuse-Medal, the highest honor of the German Informatics Society.
Inhaltsverzeichnis
Molecular computing: From conformational pattern recognition to complex processing networks.- A look at the visual modeling of plants using L-systems.- Bioinformatics and cheminformatics in the drug discovery cycle.- New developments in linking of biological databases and computer-generation of annotation: SWISS-PROT and its computer-annotated supplement TREMBL.- EpoDB: An erythropoiesis gene expression database in progress.- Recent advances in molecular distance geometry.- Three models of gene regulation in E. coli.- A new method to develop highly specific models for regulatory DNA regions.- Towards an object-oriented framework for the modeling of integrated metabolic processes.- TRRD and COMPEL databases on tranillegalscription linked to TRANSFACAS as tools for analysis and recognition of regulatory sequences.- Integrating heterogeneous datasets in genomic mapping: Radiation hybrids, YACs, genes and STS markers over the entire human chromosome X.- A clustering approach to Generalized Tree Alignment with application to Alu repeats.- Simple folding model for HP lattice proteins.- Fast protein fold recognition and accurate sequence-structure alignment.- Carbohydrates: Second-class citizens in biomedicine and in bioinformatics?.- Structural constraints and neutrality in RNA.- A systematic approach to finding new lead structures having biological activity.- Visualization and analysis of the complete yeast genome.- Virtual reality modeling for structural biology.- Evolutionary grammars: A grammatical model for genome evolution.- From DNA recombination to DNA computing via formal languages.
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