Presents up-to-date coverage of a rapidly developing field
Integrates information across distinct model systems, encompassing invertebrate and vertebrate brain
Written by leading experts in the field
Describes the wide range of research on dendrites in health and in disease
Contrasts development and degeneration
Kazuo Emoto: Professor, Department ofBiological Sciences, The University of Tokyo, Japan
Rachel Wong: Professor, Department ofStructural Biology, University of Washington, USA
Eric Huang: Professor, Department ofPathology, University of California San Francisco, USA
Casper Hoogenraad: Professor, Departmentof Biology, Utrecht University, The Netherlands
Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians.
Part 1 Introduction.- 1 Introduction.-Part 2 Basic biology of dendrites.- 2 Cytoskeletal organization – actin.- 3 Cytoskeletal organization – microtubules.- 4 Membrane trafficking mechanisms:-endo/exocytosis.- 5 Synapse to nucleus signaling.- 6 Ultrastructural methods.-7 Bioimaging of dendritic signaling.- Part 3 Patterning dendritic architectureof neurons and their populations.- 8 Self-avoidance.- 9 Dendritic tiling.- 10Mosaics and lamination.- 11 Modifying dendritic structure after function.- Part4 Cellular and molecular control of dendrite development and maintenance.- 12Molecular control of dendrite development.- 13 Sensory-dependent regulation ofdendritic morphology.- 14 Dendrite maintenance.- Part 5 Synapse formation ontodendrites.- 15 Molecular assembly of excitatory synapses.- 16 Localizingreceptors and channels across the dendritic arbor.- 17 Synaptic adhesionmolecules.- 18 Balancing excitatory and inhibitory inputs.- 19 Assembly andreassembly of synapses.- Part 6 Dendrites in disease.- 20 Dendrite developmentin autism and autism-related disorders.- 21 Dendrite degeneration inFrontotemporal dementia.- 22 Dendrite degeneration and Glaucoma.
Part 1 Introduction.- 1 Introduction.-Part 2 Basic biology of dendrites.- 2 Cytoskeletal organization - actin.- 3 Cytoskeletal organization - microtubules.- 4 Membrane trafficking mechanisms:-endo/exocytosis.- 5 Synapse to nucleus signaling.- 6 Ultrastructural methods.-7 Bioimaging of dendritic signaling.- Part 3 Patterning dendritic architectureof neurons and their populations.- 8 Self-avoidance.- 9 Dendritic tiling.- 10Mosaics and lamination.- 11 Modifying dendritic structure after function.- Part4 Cellular and molecular control of dendrite development and maintenance.- 12Molecular control of dendrite development.- 13 Sensory-dependent regulation ofdendritic morphology.- 14 Dendrite maintenance.- Part 5 Synapse formation ontodendrites.- 15 Molecular assembly of excitatory synapses.- 16 Localizingreceptors and channels across the dendritic arbor.- 17 Synaptic adhesionmolecules.- 18 Balancing excitatory and inhibitory inputs.- 19 Assembly andreassembly of synapses.- Part 6 Dendrites in disease.- 20 Dendrite developmentin autism and autism-related disorders.- 21 Dendrite degeneration inFrontotemporal dementia.- 22 Dendrite degeneration and Glaucoma.
Über den Autor
Kazuo Emoto: Professor, Department ofnBiological Sciences, The University of Tokyo, Japan
nn
Rachel Wong: Professor, Department ofnStructural Biology, University of Washington, USA
nn
Eric Huang: Professor, Department ofnPathology, University of California San Francisco, USA
nn
Casper Hoogenraad: Professor, Departmentnof Biology, Utrecht University, The Netherlands
n
Inhaltsverzeichnis
Part 1 Introduction.- 1 Introduction.-
Part 2 Basic biology of dendrites.- 2 Cytoskeletal organization - actin.- 3 Cytoskeletal organization - microtubules.- 4 Membrane trafficking mechanisms:
-endo/exocytosis.- 5 Synapse to nucleus signaling.- 6 Ultrastructural methods.-
7 Bioimaging of dendritic signaling.- Part 3 Patterning dendritic architecture
of neurons and their populations.- 8 Self-avoidance.- 9 Dendritic tiling.- 10
Mosaics and lamination.- 11 Modifying dendritic structure after function.- Part
4 Cellular and molecular control of dendrite development and maintenance.- 12
Molecular control of dendrite development.- 13 Sensory-dependent regulation of
dendritic morphology.- 14 Dendrite maintenance.- Part 5 Synapse formation onto
dendrites.- 15 Molecular assembly of excitatory synapses.- 16 Localizing
receptors and channels across the dendritic arbor.- 17 Synaptic adhesion
molecules.- 18 Balancing excitatory and inhibitory inputs.- 19 Assembly and
reassembly of synapses.- Part 6 Dendrites in disease.- 20 Dendrite development
in autism and autism-related disorders.- 21 Dendrite degeneration in
Frontotemporal dementia.- 22 Dendrite degeneration and Glaucoma.
Klappentext
Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians.
Presents up-to-date coverage of a rapidly developing field
Integrates information across distinct model systems, encompassing invertebrate and vertebrate brain
Written by leading experts in the field
Describes the wide range of research on dendrites in health and in disease
Contrasts development and degeneration
