Thoroughly updated and expanded second edition
Written by experts in this field
Provides updated terminology, including recently-identified entities
Maria M. Picken, MD, PhD
Professor of Pathology
Director of Surgical Pathology
Past President Renal Pathology Society
Loyola University Medical Center
Department of Pathology
2160 South First Avenue, Building 110, Room 2242
Maywood, IL
USA
Guillermo A. Herrera, M.D.
Albert G. And Harriet G. Smith Professor and Chair
LSU Health Shreveport
Department of Pathology
1501 Kings Highway
Shreveport, LA
USA
Ahmet Dogan, MD, PhD
Chief, Hematopathology Service
Memorial Sloan Kettering Cancer Center
Department of Pathology and Laboratory Medicine
1275 York Avenue
New York, NY
USA
The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered.
Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Part I - Introduction/General
Chapter 1: Aspects of the History and Nomenclature of Amyloid and Amyloidosis
Per Westermark
Chapter 2: Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis
Mario Nuvolone, MD, PhD; Giovanni Palladini, MD, PhD; Giampaolo Merlini, MD
Chapter 3: AA Amyloidosis
Amanda K. Ombrello, MD; Ivona Aksentijevich, MD
Chapter 4: Leukocyte cell-derived chemotaxin 2 Amyloidosis (ALECT2)
Oana Madalina Mereuta, MD PhD; Chris P. Larsen, MD; Ahmet Dogan, MD PhD
Chapter 5: The Hereditary Amyloidoses
Merrill D. Benson, MD
Chapter 6: Dialysis-Associated Amyloidosis
Paweena Susantitaphong, MD; Laura M. Dember, MD; Bertrand L. Jaber, MD, MS
Chapter 7: Localized amyloidoses and amyloidoses associated with aging outside the central nervous system
Per Westermark
Chapter 8: Amyloid Deposition in the Central Nervous System
Fausto J. Rodriguez, Maria M. Picken, John M. Lee
Part II - Non-Amyloid Protein Deposits
Chapter 9: Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis
Guillermo A. Herrera and Elba A. Turbat-Herrera
Chapter 10: Light/Heavy Chain Deposition Disease as a Systemic Disorder
Guillermo A. Herrera and Elba A. Turbat-Herrera
Chapter 11: Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits
Pierre Ronco, Alexandre Karras, and Emmanuelle Plaisier
Chapter 12: Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond
Maria M. Picken and Ahmet Dogan
Part III - Diagnosis
Chapter 13: Diagnosis of Amyloid Using Congo Red
Alexander J. Howie
Chapter 14: Diagnosis of Minimal Amyloid Deposits by Congo Red Fluorescence and Amyloidtype-specific Immunohistochemistry: A Review
Reinhold P. Linke, MD, PhD
Chapter 15: Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection
Maria M. Picken and Guillermo A. Herrera
Chapter 16: Fat tissue analysis in the management of patients with systemic amyloidosis
Johan Bijzet, Ingrid I. van Gameren, Bouke P.C. Hazenberg
Chapter 17: Generic diagnosis of amyloid – a summary of current recommendations and the editor´s comments on Chaps. 13-16
Maria M. Picken
Chapter 18: Typing of Amyloid for Routine Use on Formalin-Fixed Paraffin Sections of 626 Patients by Applying Amyloidtype-Specific Immunohistochemistry: A Review
Reinhold P. Linke, MD, PhD
Chapter 19: Amyloid Typing: Experience from a Large Referral Centre
Janet A. Gilbertson, Julian D. Gillmore and Philip N. Hawkins
Chapter 20: Options for amyloid typing in renal pathology – the advantages of frozen section immunofluorescence and a summary of general recommendations regarding immunohistochemistry methods
Maria M. Picken
Chapter 21: Amyloid typing in plastic embedded tissue by immune-gold-silver method
Anne Räisänen-Sokolowski and Tom Tornroth
Chapter 22: The Role of Immuno-electron Microscopy in Amyloid Typing: The Experience of the Pavia Referral Center
Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici, Gian Luca Capello, Marco Paulli, and Giampaolo Merlini
Chapter 23: Classification of amyloidosis by mass spectrometry-based proteomics
Ahmet Dogan, MD, PhD
Chapter 24: The Role of Differential Proteomics in Amyloid Typing: The Experience of the Pavia Referral Center
Francesca Lavatelli, Francesca Brambilla, Andrea Di Fonzo, Giovanni Ferraro, Giovanni Palladini, Pierluigi Mauri and Giampaolo Merlini
Part IV- Ancillary Studies of Amyloidosis
Chapter 25: Laboratory Support for Diagnosis of Amyloidosis
David L Murray, M.D., Ph.D. and Jerry A. Katzmann, Ph.D.
Chapter 26: Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis
John C. Lee, M.D., Lawreen H. Connors, Ph.D., Carl J. O´Hara, M.D.
Chapter 27: Laboratory Methods for the Diagnosis of Hereditary Amyloidoses
S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, and W. Edward Highsmith, Jr.
Part V- Organ Involvement in Amyloidoses
Chapter 28: Amyloidoses of the Kidney, the Lower Urinary and Genital Tracts (male and female) and the Breast
Maria M. Picken and Ahmet Dogan
Chapter 29: Cardiac Amyloidosis
Carmela D. Tan, M.D. and E. Rene Rodriguez, M.D.
Chapter 30: Amyloidosis of the Gastrointestinal Tract and Liver
Oscar W. Cummings, M.D., Merrill Benson, M.D.
Chapter 31: Peripheral Nerve Amyloidosis
Adam J. Loavenbruck, JaNean K. Engelstad, Christopher J. Klein
Chapter 32: Amyloidosis of the Lymph Nodes and the Spleen
Filiz Sen MD, Ahmet Dogan MD PhD
Chapter 33: Amyloidosis of the lung
Karen L. Grogg MD, Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD
Chapter 34: Cutaneous Amyloidosis
Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD
Chapter 35: Iatrogenic pharmaceutical amyloidosis associated with insulin and enfuvirtide administration
Ahmet Dogan MD PhD, Oana Madalina Mereuta MD PhD
Part VI- Clinical Issues and Therapy
Chapter 36: Clinical and pathologic issues in patients with amyloidosis – summary and practical comments regarding diagnosis, therapy and solid organ transplantation
Maria M. Picken and Kevin Barton
Chapter 37: Emerging Therapies for Amyloidosis
Merrill D. Benson
Chapter 38: Modern Therapies in AA Amyloidosis
Amanda K. Ombrello, M.D.
Chapter 39: Medicolegal Issues of Amyloidosis
Timothy Craig Allen, M.D., J.D.
Chapter 40: Amyloidosis from the Patient's Perspective
Muriel Finkel
The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered.
Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Introduction/general.- Aspects of the history and nomenclature of amyloid and amyloidosis.- Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis.- AA amyloidosis.- Non-Immunoglobulin and non-AA amyloidoses.- The hereditary amyloidoses.- Dialysis-associated amyloidosis.- Localized amyloidoses and amyloidoses associated with aging outside the central nervous system.- Central nervous system amyloid.- Non-amyloid protein deposits.- Differential diagnosis of amyloid in surgical pathology: organized deposits and other material in the differential diagnosis of amyloidosis.- Light /heavy chain deposition disease as a systemic disease.- Glomerulonephritis with non-organized monoclonal immunoglobulin deposits.- Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond.- Diagnosis.- Diagnosis of amyloid using Congo red - polarized and fluorescence.- Thioflavin T stain for amyloid detection.- Fat tissue analysis in the management of patients with systemic amyloidosis.- Generic diagnosis of amyloid - recent developments and summary of current recommendations.- Amyloid typing on formalin-fixed paraffin sections by immunohistochemistry - experience from two large referral centers.- Options for amyloid typing in renal pathology - the advantages of frozen section immunofluorescence.- Amyloid typing by immuno-electron microscopy.- Classification of amyloidosis by mass spectrometry-based proteomics.- Summary and practical recommendation regarding amyloid typing using antibody-based and proteomic methods.- Ancillary studies of amyloidosis.- Laboratory support for diagnosis of amyloidosis.- Bone marrow biopsy and its utility in the diagnosis of AL amyloidosis and other plasma cell dyscrasias.- Molecular methods for the diagnosis of hereditary amyloidosis.- Radiologic support for diagnosis and monitoring of amyloidosis - established techniques and recent developments.- Organ involvement inamyloidoses.- Amyloidoses of the Kidney and Genitourinary tract.- Cardiac amyloidosis.- Amyloidosis of the Gastrointestinal tract and Liver.- Peripheral nerve amyloidosis.- Amyloidoses of the Pulmonary and upper respiratory tract.- Amyloidoses involving the skin.- Clinical issues and therapy.- Clinico-pathologic issues in patients with amyloidosis.- Solid organ transplantation in amyloidosis and issues pertaining to domino liver transplantation.- Emerging therapies for amyloidosis.- Clinical trials.- Modern therapies in AA amyloidosis.- Medico legal issues of amyloidosis.- Amyloidosis from the patient's perspective.
Maria M. Picken, MD, PhDProfessor of PathologyDirector of Surgical PathologyPast President Renal Pathology SocietyLoyola University Medical CenterDepartment of Pathology2160 South First Avenue, Building 110, Room 2242Maywood, ILUSAGuillermo A. Herrera, M.D.Albert G. And Harriet G. Smith Professor and ChairLSU Health ShreveportDepartment of Pathology1501 Kings HighwayShreveport, LA USAAhmet Dogan, MD, PhDChief, Hematopathology ServiceMemorial Sloan Kettering Cancer CenterDepartment of Pathology and Laboratory Medicine1275 York AvenueNew York, NY USA
Über den Autor
Maria M. Picken, MD, PhDProfessor of PathologyDirector of Surgical PathologyPast President Renal Pathology SocietyLoyola University Medical CenterDepartment of Pathology2160 South First Avenue, Building 110, Room 2242Maywood, ILUSAGuillermo A. Herrera, M.D.Albert G. And Harriet G. Smith Professor and ChairLSU Health ShreveportDepartment of Pathology1501 Kings HighwayShreveport, LA USAAhmet Dogan, MD, PhDChief, Hematopathology ServiceMemorial Sloan Kettering Cancer CenterDepartment of Pathology and Laboratory Medicine1275 York AvenueNew York, NY USA
Inhaltsverzeichnis
Part I - Introduction/General
Chapter 1:
Aspects of the History and Nomenclature of Amyloid and Amyloidosis
Per Westermark
Chapter 2: Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis
Mario Nuvolone, MD, PhD; Giovanni Palladini, MD, PhD; Giampaolo Merlini, MD
Chapter 3:
AA Amyloidosis
Amanda K. Ombrello, MD; Ivona Aksentijevich, MD
Chapter 4: Leukocyte cell-derived chemotaxin 2 Amyloidosis (ALECT2)
Oana Madalina Mereuta, MD PhD; Chris P. Larsen, MD; Ahmet Dogan, MD PhD
Chapter 5: The Hereditary Amyloidoses
Merrill D. Benson, MD
Chapter 6: Dialysis-Associated Amyloidosis
Paweena Susantitaphong, MD; Laura M. Dember, MD; Bertrand L. Jaber, MD, MS
Chapter 7:
Localized amyloidoses and amyloidoses associated with aging outside the central nervous system
Per Westermark
Chapter 8: Amyloid Deposition in the Central Nervous System
Fausto J. Rodriguez, Maria M. Picken, John M. Lee
Part II - Non-Amyloid Protein Deposits
Chapter 9: Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis
Guillermo A. Herrera and Elba A. Turbat-Herrera
Chapter 10: Light/Heavy Chain Deposition Disease as a Systemic Disorder
Guillermo A. Herrera and Elba A. Turbat-Herrera
Chapter 11: Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits
Pierre Ronco, Alexandre Karras, and Emmanuelle Plaisier
Chapter 12: Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond
Maria M. Picken and Ahmet Dogan
Part III - Diagnosis
Chapter 13: Diagnosis of Amyloid Using Congo Red
Alexander J. Howie
Chapter 14: Diagnosis of Minimal Amyloid Deposits by Congo Red Fluorescence and Amyloidtype-specific Immunohistochemistry: A Review
Reinhold P. Linke, MD, PhD
Chapter 15: Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection
Maria M. Picken and Guillermo A. Herrera
Chapter 16: Fat tissue analysis in the management of patients with systemic amyloidosis
Johan Bijzet, Ingrid I. van Gameren, Bouke P.C. Hazenberg
Chapter 17: Generic diagnosis of amyloid - a summary of current recommendations and the editor's comments on Chaps. 13-16
Maria M. Picken
Chapter 18: Typing of Amyloid for Routine Use on Formalin-Fixed Paraffin Sections of 626 Patients by Applying Amyloidtype-Specific Immunohistochemistry: A Review
Reinhold P. Linke, MD, PhD
Chapter 19: Amyloid Typing: Experience from a Large Referral Centre
Janet A. Gilbertson, Julian D. Gillmore and Philip N. Hawkins
Chapter 20: Options for amyloid typing in renal pathology - the advantages of frozen section immunofluorescence and a summary of general recommendations regarding immunohistochemistry methods
Maria M. Picken
Chapter 21: Amyloid typing in plastic embedded tissue by immune-gold-silver method
Anne Räisänen-Sokolowski and Tom Tornroth
Chapter 22: The Role of Immuno-electron Microscopy in Amyloid Typing: The Experience of the Pavia Referral Center
Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici, Gian Luca Capello, Marco Paulli, and Giampaolo Merlini
Chapter 23: Classification of amyloidosis by mass spectrometry-based proteomics
Ahmet Dogan, MD, PhD
Chapter 24: The Role of Differential Proteomics in Amyloid Typing: The Experience of the Pavia Referral Center
Francesca Lavatelli, Francesca Brambilla, Andrea Di Fonzo, Giovanni Ferraro, Giovanni Palladini, Pierluigi Mauri and Giampaolo Merlini
Part IV- Ancillary Studies of Amyloidosis
Chapter 25: Laboratory Support for Diagnosis of Amyloidosis
David L Murray, M.D., Ph.D. and Jerry A. Katzmann, Ph.D.
Chapter 26: Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis
John C. Lee, M.D., Lawreen H. Connors, Ph.D., Carl J. O'Hara, M.D.
Chapter 27: Laboratory Methods for the Diagnosis of Hereditary Amyloidoses
S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, and W. Edward Highsmith, Jr.
Part V- Organ Involvement in Amyloidoses
Chapter 28: Amyloidoses of the Kidney, the Lower Urinary and Genital Tracts (male and female) and the Breast
Maria M. Picken and Ahmet Dogan
Chapter 29: Cardiac Amyloidosis
Carmela D. Tan, M.D. and E. Rene Rodriguez, M.D.
Chapter 30: Amyloidosis of the Gastrointestinal Tract and Liver
Oscar W. Cummings, M.D., Merrill Benson, M.D.
Chapter 31: Peripheral Nerve Amyloidosis
Adam J. Loavenbruck, JaNean K. Engelstad, Christopher J. Klein
Chapter 32: Amyloidosis of the Lymph Nodes and the Spleen
Filiz Sen MD, Ahmet Dogan MD PhD
Chapter 33: Amyloidosis of the lung
Karen L. Grogg MD, Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD
Chapter 34: Cutaneous Amyloidosis
Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD
Chapter 35: Iatrogenic pharmaceutical amyloidosis associated with insulin and enfuvirtide administration
Ahmet Dogan MD PhD, Oana Madalina Mereuta MD PhD
Part VI- Clinical Issues and Therapy
Chapter 36: Clinical and pathologic issues in patients with amyloidosis - summary and practical comments regarding diagnosis, therapy and solid organ transplantation
Maria M. Picken and Kevin Barton
Chapter 37: Emerging Therapies for Amyloidosis
Merrill D. Benson
Chapter 38: Modern Therapies in AA Amyloidosis
Amanda K. Ombrello, M.D.
Chapter 39: Medicolegal Issues of Amyloidosis
Timothy Craig Allen, M.D., J.D.
Chapter 40: Amyloidosis from the Patient's Perspective
Muriel Finkel
Klappentext
The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered.
Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Thoroughly updated and expanded second edition
Written by experts in this field
Provides updated terminology, including recently-identified entities
