Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.
Part I: Pharmacological Considerations for Drug Delivery Systems in Cancer Medicine Systemically Administered Drugs Reginald B. Ewesuedo and Mark J. Ratain Regional Administration of Antineoplastic Drugs Maurie Markman Theoretical Analyses and Simulations of Anticancer Drug Delivery Ardith W. El-Kareh and Timothy W. Secomb Part II: Technologies Available for Use in Cancer Drug Delivery Systems Biopolymers for Parenteral Drug Delivery in Cancer Treatment Wolfgang Friess Hydrogels in Cancer Drug Delivery Systems Sung-Joo Hwang, Namjin Baek, Haesun Park, and Kinam Park Microparticle Drug Delivery Systems Duane T. Birnbaum and Lisa Brannon-Peppas Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future Robert G. L. Shorr, Michael Bentley, Simon Zhsao, Richard Parker, and Brendan Whittle Emulsions As Anticancer Delivery Systems S. Esmail Tabibi Part III. Current Applications: Products Approved or in Advanced Clinical Development Liposomal Drug Delivery Systems for Cancer Therapy Daryl C. Drummond, Dmitri Kirpotin, Christopher C. Benz, John W. Park, and Keelung Hong Gliadel®: A New Method for the Treatment of Malignant Brain Tumors Francesco DiMeco, Henry Brem, Jon D. Weingart, and Alessandro Olivi Intralesional Chemotherapy with Injectable Collagen Gel Formulations Elaine K. Orenberg Sustained-Release Drug Delivery with DepoFoam Sankaram B. Mantripragada and Stephen B. Howell Cancer Vaccines Susanne Osanto Part IV. Future Directions: Novel Cancer Drug Targets and Delivery Systems Gene Therapy of Cancer Susanne Osanto Progress in Antisense Technology Stanley T. Crooke Tumor Vaccines Francesco M. Marincola Diagnosis and Treatment of HumanDisease Using Telomerase As a Novel Target Lynne W. Elmore and Shawn E. Holt Index
A major difficulty in successfully treating cancer with drugs is achieving adequate drug concentrations in the diseased areas without overexposing drug-sensitive normal tissues. In a number of cases, specialized drug delivery systems are required to realize a therapeutic gain. In Drug Delivery Systems in Cancer Therapy, Dennis M. Brown has assembled a panel of leading experts to survey all the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. They also profile the use of novel formulation technologies-including synthetic polymers and biomaterials for sustained drug release to achieve greater therapeutic effect-that have demonstrated efficacy in a number of approved and late-stage clinical products. They also consider the benefits of, and future opportunities for, various drug delivery systems, as well as the experimental techniques used in their evaluation. Although the focus is primarily on small molecule delivery, many of the technologies described can also be effective in delivering larger biomolecules.
Comprehensive, cutting-edge, and highly practical, Drug Delivery Systems in Cancer Therapy captures for experimental oncologists, medicinal chemists, and pharmacologists the universe of approaches, technologies, and systems available for substantially enhancing the therapeutic outcome of anticancer drug delivery today.
"this book should serve as a valuable resource to anyone interested in the field of drug delivery systems in cancer therapy. It would be particularly useful to individuals developing novel agents that might benefit from selective packaging and delivery approaches."-Doody's Health Sciences Book Review Journal
"The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development." - Tumori
"...provide(s) concise and easily understandable clinical significance, current status, and future perspective of anticancer drug delivery." - Pharmaceutical Research
A major difficulty in successfully treating cancer with drugs is achieving adequate drug concentrations in the diseased areas without overexposing drug-sensitive normal tissues. In a number of cases, specialized drug delivery systems are required to realize a therapeutic gain. In Drug Delivery Systems in Cancer Therapy, Dennis M. Brown has assembled a panel of leading experts to survey all the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. They also profile the use of novel formulation technologies-including synthetic polymers and biomaterials for sustained drug release to achieve greater therapeutic effect-that have demonstrated efficacy in a number of approved and late-stage clinical products. They also consider the benefits of, and future opportunities for, various drug delivery systems, as well as the experimental techniques used in their evaluation. Although the focus is primarily on small molecule delivery, many of the technologies described can also be effective in delivering larger biomolecules.
Comprehensive, cutting-edge, and highly practical, Drug Delivery Systems in Cancer Therapy captures for experimental oncologists, medicinal chemists, and pharmacologists the universe of approaches, technologies, and systems available for substantially enhancing the therapeutic outcome of anticancer drug delivery today. Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.
I: Pharmacological Considerations for Drug Delivery Systems in Cancer Medicine.- 1 Systemically Administered Drugs.- 2 Regional Administration of Antineoplastic Drugs.- 3 Theoretical Analyses and Simulations of Anticancer Drug Delivery.- II: Technologies Available for Use in Cancer Drug Delivery Systems.- 4 Biopolymers for Parenteral Drug Delivery in Cancer Treatment.- 5 Hydrogels in Cancer Drug Delivery Systems.- 6 Microparticle Drug Delivery Systems.- 7 Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future.- 8 Emulsions As Anticancer Delivery Systems.- III: Current Applications: Products Approved or in Advanced Clinical Development.- 9 Liposomal Drug Delivery Systems for Cancer Therapy.- 10 Gliadel®: A New Method for the Treatment of Malignant Brain Tumors.- 11 Intralesional Chemotherapy with Injectable Collagen Gel Formulations.- 12 Sustained-Release Drug Delivery with DepoFoam.- 13 Cancer Vaccines.- IV: Future Directions: Novel Cancer Drug Targets and Delivery Systems.- 14 Gene Therapy of Cancer.- 15 Progress in Antisense Technology.- 16 Tumor Vaccines.- 17 Diagnosis and Treatment of Human Disease Using Telomerase As a Novel Target.
"this book should serve as a valuable resource to anyone interested in the field of drug delivery systems in cancer therapy. It would be particularly useful to individuals developing novel agents that might benefit from selective packaging and delivery approaches."-Doody's Health Sciences Book Review Journal
"The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development." - Tumori
"...provide(s) concise and easily understandable clinical significance, current status, and future perspective of anticancer drug delivery." - Pharmaceutical Research
Inhaltsverzeichnis
Part I: Pharmacological Considerations for Drug Delivery Systems in Cancer Medicinen n Systemically Administered Drugsn Reginald B. Ewesuedo and Mark J. Ratainn n Regional Administration of Antineoplastic Drugsn Maurie Markmann n Theoretical Analyses and Simulations of Anticancer Drug Deliveryn Ardith W. El-Kareh and Timothy W. Secombn n Part II: Technologies Available for Use in Cancer Drug Delivery Systemsn n Biopolymers for Parenteral Drug Delivery in Cancer Treatmentn Wolfgang Friessn n Hydrogels in Cancer Drug Delivery Systemsn Sung-Joo Hwang, Namjin Baek, Haesun Park, and Kinam Parkn n Microparticle Drug Delivery Systemsn Duane T. Birnbaum and Lisa Brannon-Peppasn n Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Futuren Robert G. L. Shorr, Michael Bentley, Simon Zhsao, Richard Parker, and Brendan Whittlen n Emulsions As Anticancer Delivery Systemsn S. Esmail Tabibin n Part III. Current Applications: Products Approved or in Advanced Clinical Developmentn n Liposomal Drug Delivery Systems for Cancer Therapyn Daryl C. Drummond, Dmitri Kirpotin, Christopher C. Benz, John W. Park, and Keelung Hongn n Gliadel®: A New Method for the Treatment of Malignant Brain Tumorsn Francesco DiMeco, Henry Brem, Jon D. Weingart, and Alessandro Olivin n Intralesional Chemotherapy with Injectable Collagen Gel Formulationsn Elaine K. Orenbergn n Sustained-Release Drug Delivery with DepoFoamn Sankaram B. Mantripragada and Stephen B. Howelln n Cancer Vaccinesn Susanne Osanton n Part IV. Future Directions: Novel Cancer Drug Targets and Delivery Systemsn n Gene Therapy of Cancern Susanne Osanton n Progress in Antisense Technologyn Stanley T. Crooken n Tumor Vaccinesn Francesco M. Marincolan n Diagnosis and Treatment of HumanDisease Using Telomerase As a Novel Targetn Lynne W. Elmore and Shawn E. Holtn n Index
Klappentext
Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.
Includes supplementary material: sn.pub/extras
