This is the first of two volumes on the topic
Together they present an overview of recent progress in this area
Both theoretical and practical aspects are covered
Up-to-date information for virologists, immunologists, public health professionals and infectious disease physicians
Richard W. Compans is a Professor of Microbiology and Immunology and Scientific Director of Influenza Pathogenesis and Immunology Research Center, Emory University, School of Medicine, Atlanta, GA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology. Michael B.A. Oldstone is a Professor at the Department of Immunology and Microbial Science at the Scripps Research Institute, La Jolla, CA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology.
This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
Part I: Molecular determinants of pathogenicity
The Hemagglutinin - a Determinant of Pathogenicity
Eva Böttcher-Friebertshäuser, Wolfgang Garten, Mikhail Matrosovich, and Hans Dieter Klenk
Molecular determinants of pathogenicity in the polymerase complex
Gülsah Gabriel and Ervin Fodor
Part II: Virus entry and cell tropism
Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range
Xiaoli Xiong, John W. McCauley, David A. Steinhauer
Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology
Charles J. Russell
Part III: Transmission and Pandemics
Pandemic Preparedness and the Influenza Risk Assessment Tool (IRAT)
Nancy J. Cox, Susan C. Trock and Stephen A. Burke
Avian influenza virus transmission to mammals
S. Herfst, M. Imai, Y. Kawaoka and R.A.M. Fouchier
Transmission in the Guinea Pig Model
Anice C. Lowen, Nicole M. Bouvier and John Steel
Enhancement of influenza virus transmission by gene reassortment
Chengjun Li and Hualan Chen
Swine and Influenza: A Challenge to One Health Research
Robert E. Kahn, Wenjun Ma and Jürgen A. Richt
Part IV: Animal models and pathogenesis
Influenza Pathobiology and Pathogenesis in Avian Species
Monique S. Fran?a and Justin D. Brown
Molecular determinants of influenza virus pathogenesis in mice
Ram P. Kamal, Jaqueline M. Katz, and Ian A. York
Mammalian models for the study of H7 virus pathogenesis and transmission
Jessica A. Belser and Terrence M. Tumpey
Pathogenesis and vaccination of influenza A virus in swine
Daniela S. Rajao, Tavis K. Anderson, Phillip C. Gauger, Amy L. Vincent
Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis
Amber M. Smith and Jonathan A. McCullers
Part V: Evolution, Antigenic Variation
Evolution and Ecology of Influenza A viruses
Sun-Woo Yoon, Richard J. Webby and Robert G. Webster
Influenza A virus reassortment
John Steel and Anice C. Lowen
Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses
Ruben O Donis
This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
The Hemagglutinin - a Determinant of Pathogenicity.- Molecular determinants of pathogenicity in the polymerase complex.- Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range.- Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology.- Pandemic Preparedness and the Influenza Risk Assessment Tool (IRAT).- Avian influenza virus transmission to mammals.- Transmission in the Guinea Pig Model.- Enhancement of influenza virus transmission by gene reassortment.- Swine and Influenza: A Challenge to One Health Research.- Influenza Pathobiology and Pathogenesis in Avian Species.- Molecular determinants of influenza virus pathogenesis in mice.- Mammalian models for the study of H7 virus pathogenesis and transmission.- Pathogenesis and vaccination of influenza A virus in swine.- Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis.- Evolution and Ecology of Influenza A viruses.- Influenza A virus reassortment.- Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses.
Über den Autor
Richard W. Compans is a Professor of Microbiology and Immunology and Scientific Director of Influenza Pathogenesis and Immunology Research Center, Emory University, School of Medicine, Atlanta, GA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology. Michael B.A. Oldstone is a Professor at the Department of Immunology and Microbial Science at the Scripps Research Institute, La Jolla, CA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology.
Inhaltsverzeichnis
The Hemagglutinin - a Determinant of Pathogenicity.- Molecular determinants of pathogenicity in the polymerase complex.- Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range.- Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology.- Pandemic Preparedness and the Influenza Risk Assessment Tool (IRAT).- Avian influenza virus transmission to mammals.- Transmission in the Guinea Pig Model.- Enhancement of influenza virus transmission by gene reassortment.- Swine and Influenza: A Challenge to One Health Research.- Influenza Pathobiology and Pathogenesis in Avian Species.- Molecular determinants of influenza virus pathogenesis in mice.- Mammalian models for the study of H7 virus pathogenesis and transmission.- Pathogenesis and vaccination of influenza A virus in swine.- Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis.- Evolution and Ecology of Influenza A viruses.- Influenza A virus reassortment.- Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses.
Klappentext
This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
This is the first of two volumes on the topic
Together they present an overview of recent progress in this area
Both theoretical and practical aspects are covered
Up-to-date information for virologists, immunologists, public health professionals and infectious disease physicians
Includes supplementary material: sn.pub/extras
