Broadens your understanding of endogenous mono-ADP-ribosylation reactions
Brings together exciting recent findings on ADP-ribosylation
Written by leading experts in the field
Friedrich Koch-Nolte is a professor at University Hospital Hamburg-Eppendorf, Institute for Immunology, Hamburg, Germany
This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:
· Evolution and detection of endogenous ADP-ribosylation
· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)
· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)
The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
Part I: Evolution and Detection of Endogenous ADP-Ribosylation
The natural history of ADP-ribosyltransferases and the ADP ribosylation system
L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer
Identification and Analysis of ADP-ribosylated Proteins
Friedrich Haag and Friedrich Buck
Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)
Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine
Klaus Aktories, Gudula Schmidt and Alexander E. Lang
Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein
Hideaki Tsuge, Toshiharu Tsurumura
Regulation of nitrogenase by reversible mono-ADP-ribosylation
Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo
ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells
Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch
Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish
Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe
Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)
Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family
Ana Filipa Pinto and Herwig Schüler
Function and regulation of the mono-ADP-ribosyltransferase ARTD10
Max Kaufmann, Karla L. H. Feijs, and Bernhard Lüscher
Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-?1 mono-ADP-ribosylation by ARTD15
Maria Di Girolamo
This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:
· Evolution and detection of endogenous ADP-ribosylation
· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)
· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)
The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:
· Evolution and detection of endogenous ADP-ribosylation
· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)
· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)
The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
The natural history of ADP-ribosyltransferases and the ADP ribosylation system.- Identification and Analysis of ADP-ribosylated Proteins.- Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine.- Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein.- Regulation of nitrogenase by reversible mono-ADP-ribosylation.- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells.- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish.- Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.- Function and regulation of the mono-ADP-ribosyltransferase ARTD10.- Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-beta1 mono-ADP-ribosylation by ARTD15.
Über den Autor
Friedrich Koch-Nolte is a professor at University Hospital Hamburg-Eppendorf, Institute for Immunology, Hamburg, Germany
Inhaltsverzeichnis
Part I: Evolution and Detection of Endogenous ADP-Ribosylation The natural history of ADP-ribosyltransferases and the ADP ribosylation systemL. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer Identification and Analysis of ADP-ribosylated ProteinsFriedrich Haag and Friedrich Buck Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs) Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamineKlaus Aktories, Gudula Schmidt and Alexander E. Lang Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate proteinHideaki Tsuge, Toshiharu Tsurumura Regulation of nitrogenase by reversible mono-ADP-ribosylationVivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cellsBjörn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfishTsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs) Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP familyAna Filipa Pinto and Herwig Schüler Function and regulation of the mono-ADP-ribosyltransferase ARTD10Max Kaufmann, Karla L. H. Feijs, and Bernhard Lüscher Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-ß1 mono-ADP-ribosylation by ARTD15Maria Di Girolamo
Klappentext
This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:
· Evolution and detection of endogenous ADP-ribosylation
· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)
· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)
The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
Broadens your understanding of endogenous mono-ADP-ribosylation reactions
Brings together exciting recent findings on ADP-ribosylation
Written by leading experts in the field
Includes supplementary material: sn.pub/extras
