Brings together recent discoveries and developments in brain tumor cellular and molecular mechanisms
Includes detailed protocols that are ready for the lab
Features expert tips and key implementation advice to ensure successful results
Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in "in vivo” experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed deillegalscription and implementation advice that is essential for achieving successful results.
Authoritative and cutting-edge,
Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.
Part I: Introduction
Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?
Lois A. Lampson
Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints
José M. Orellana-Muriana
Part II: Animal Models Offer Insights into Human Brain Neoplasms
The VM Mouse Model of Glioblastoma Multiforme
Thomas N. Seyfried, Laura M. Shelton, and Leanne C. Huysentruyt
Oligodendroglioma Models
Nanna Lindberg and Lene Uhrbom
Medulloblastoma Model
Jasmine Lau and William A. Weiss
Learning about Retinoblastoma from Mouse Models that Missed
David Cobrinik
Ependymoma Models
Jesús Vaquero and Mercedes Zurita
Meningioma Models
Jessica Rainey and Randy L. Jensen
Pituitary Models
Walavan Sivakumar and William T. Couldwell
Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors
Kelly Burrell, Elena Bogdanovic, Shahrzad Jalali, Gelareh Zadeh, and Abhijit Guha
Part III: Cellular, Molecular, and Genetic Basis of Brain Tumors: Data from Animal Models
Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children
Aparna Kaul, Ibrahim Hussain, and David H. Gutmann
EGFR and Tumor–Suppressor Function in Brain Cancer Development
Julie Lessard and Al Charest
Part IV: Therapies in the Treatment of Malignant Glioma: Data from Animal Models
Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts
Hikmat Assi, Marianela Candolfi, Pedro R. Lowenstein, and Maria G. Castro
Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models
Kristen A. Batich, Bryan D. Choi, and Duane A. Mitchell
Assessing Mechanisms of Glioblastoma Invasion
Stephen M. Robbins and Donna L. Senger
Part V: Imaging Technologies in Animal Tumor Models: Measuring Brain Tumor Growth and Metabolism
Positron Emission Tomography (PET)-Based Molecular Imaging
Yannic Waerzeggers, Thomas Viel, Sonja Schäfers, Stefan Wagner, Andreas Faust, Burkhard Riemann, Klaus Kopka, Otmar Schober, Klaus Schäfers, and Andreas H. Jacobs
In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)
Rui V. Simões, Ana Paula Candiota, Margarida Julià-Sapé, and Carles Arús
Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research
André Constantinesco, Christian Goetz, and Philippe Choquet
From the reviews:
"This text covers the comparative histopathology, molecular genetics, and growth of gliomas in several animal models inc. the glioblastoma multiforme and M3 model. ... I highly recommend this book to neuropathologists, researcher, neurosurgeons, and neurologists ... .” (Joseph J. Grenier, Amazon.com, May, 2014)
This book brings together developments in 'in vivo' experimental tumor research of the last two decades that have advanced understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms.
Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in "in vivo" experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed deillegalscription and implementation advice that is essential for achieving successful results.
Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.
Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?.- Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints.- The VM Mouse Model of Glioblastoma Multiforme.- Oligodendroglioma Models.- Medulloblastoma Model.- Learning about Retinoblastoma from Mouse Models that Missed.- Ependymoma Models.- Meningioma Models.- Pituitary Models.- Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors.- Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children.- EGFR and Tumor-Suppressor Function in Brain Cancer Development.- Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts.- Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models.- Assessing Mechanisms of Glioblastoma Invasion.- Positron Emission Tomography (PET)-Based Molecular Imaging.- In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)- Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research.
From the reviews:
"This text covers the comparative histopathology, molecular genetics, and growth of gliomas in several animal models inc. the glioblastoma multiforme and M3 model. ... I highly recommend this book to neuropathologists, researcher, neurosurgeons, and neurologists ... ." (Joseph J. Grenier, Amazon.com, May, 2014)
Inhaltsverzeichnis
Part I: Introduction
Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?
Lois A. Lampson
Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints
José M. Orellana-Muriana
Part II: Animal Models Offer Insights into Human Brain Neoplasms
The VM Mouse Model of Glioblastoma Multiforme
Thomas N. Seyfried, Laura M. Shelton, and Leanne C. Huysentruyt
Oligodendroglioma Models
Nanna Lindberg and Lene Uhrbom
Medulloblastoma Model
Jasmine Lau and William A. Weiss
Learning about Retinoblastoma from Mouse Models that Missed
David Cobrinik
Ependymoma Models
Jesús Vaquero and Mercedes Zurita
Meningioma Models
Jessica Rainey and Randy L. Jensen
Pituitary Models
Walavan Sivakumar and William T. Couldwell
Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors
Kelly Burrell, Elena Bogdanovic, Shahrzad Jalali, Gelareh Zadeh, and Abhijit Guha
Part III: Cellular, Molecular, and Genetic Basis of Brain Tumors: Data from Animal Models
Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children
Aparna Kaul, Ibrahim Hussain, and David H. Gutmann
EGFR and Tumor-Suppressor Function in Brain Cancer Development
Julie Lessard and Al Charest
Part IV: Therapies in the Treatment of Malignant Glioma: Data from Animal Models
Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts
Hikmat Assi, Marianela Candolfi, Pedro R. Lowenstein, and Maria G. Castro
Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models
Kristen A. Batich, Bryan D. Choi, and Duane A. Mitchell
Assessing Mechanisms of Glioblastoma Invasion
Stephen M. Robbins and Donna L. Senger
Part V: Imaging Technologies in Animal Tumor Models: Measuring Brain Tumor Growth and Metabolism
Positron Emission Tomography (PET)-Based Molecular Imaging
Yannic Waerzeggers, Thomas Viel, Sonja Schäfers, Stefan Wagner, Andreas Faust, Burkhard Riemann, Klaus Kopka, Otmar Schober, Klaus Schäfers, and Andreas H. Jacobs
In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)
Rui V. Simões, Ana Paula Candiota, Margarida Julià-Sapé, and Carles Arús
Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research
André Constantinesco, Christian Goetz, and Philippe Choquet
Klappentext
Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in "in vivo" experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed deillegalscription and implementation advice that is essential for achieving successful results.rn rnAuthoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.
Brings together recent discoveries and developments in brain tumor cellular and molecular mechanisms
rn
Includes detailed protocols that are ready for the lab
rn
Features expert tips and key implementation advice to ensure successful results
rn
