Airways inflammation is a complex biological phenomenon resulting from the recruitment and activation of numerous cell types. Airways inflammation contributes to the pathophysiology of airways disease. An understanding of the mechanisms that regulate inflammatory cell function is essential for the development of novel anti-inflammatory drugs for the treatment of common respiratory diseases such as asthma and COPD. This book provides a collection of valuable reviews on the major inflammatory cells involved in airways disease and examines the pharmacology of current anti-inflammatory drugs used in the treatment of airways disease. Moreover, an insight into the development of emerging drug therapies is also highlighted. This book is a must for the library of any researcher or clinician interested in the pathophysiology of airways disease.|Airways inflammation is a complex biological phenomenon resulting from the recruitment and activation of numerous cell types. Airways inflammation contributes to the pathophysiology of airways disease. An understanding of the mechanisms that regulate inflammatory cell function is essential for the development of novel anti-inflammatory drugs for the treatment of common respiratory diseases such as asthma and COPD. This book provides a collection of valuable reviews on the major inflammatory cells involved in airways disease and examines the pharmacology of current anti-inflammatory drugs used in the treatment of airways disease. Moreover, an insight into the development of emerging drug therapies is also highlighted. This book is a must for the library of any researcher or clinician interested in the pathophysiology of airways disease.|Airways disease encompasses a broad range of pathologies including Bronchial Asthma, Rhinitis, Chronic Obstructive Pulmonary Disease, Bronchitis, Acute Bronchiolitis, Emphysema and Fibrosing Alveolitis. A characteristic feature of these diseases is the recruitment and activation of numerous cell types. Airways inflammation contributes to the pathophysiology of airways disease...
Pathological spectrum of airway inflammation.- Role of basophils in airways inflammation.- Platelets.- Neutrophils.- Eosinophils in asthma.- Fibroblasts and myofibroblasts.- Airway macrophages and dendritic cells.- Contribution of endothelial cells to airway inflammation.- Airway epithelial cells.- Airway smooth muscle cells.- Drugs that reduce airways inflammation.- T cells in the lung.
Airways inflammation is a complex biological phenomenon resulting fromthe recruitment and activation of numerous cell types. Airwaysinflammation contributes to the pathophysiology of airways disease. Anunderstanding of the mechanisms that regulate inflammatory cell functionis essential for the development of novel anti-inflammatory drugs forthe treatment of common respiratory diseases such as asthma and COPD.This book provides a collection of valuable reviews on the majorinflammatory cells involved in airways disease and examines thepharmacology of current anti-inflammatory drugs used in the treatment ofairways disease. Moreover, an insight into the development of emergingdrug therapies is also highlighted.This book is a must for the library of any researcher or clinicianinterested in the pathophysiology of airways disease.
Contents. List of Contributors. Preface. Peter K. Jeffery: Pathological spectrum of airway inflammation. Gianni Marone, Anna Ciccarelli, Giuseppe Spadaro and Anna Maria Onorati: Role of basophils in airways inflammation. Paolo Gresele and Roberta Vezza: Platelets. Moira Whyte: Neutrophils. Anthony J. Coyle, Jose Carlos Gutierrez-Ramos: Eosinophils in asthma. Ian A. Akers, Robin J. McAnulty and Geoffrey J. Laurent: Fibroblasts and myofibroblasts. Elaine Lee and Stephen A. Kilfeather: Airway macrophages and dendritic cells. Anne Burke-Gaffney and Paul G. Hellewell: Contribution of endothelial cells to airway inflammation. Jagdish Laxman Devalia, Jia Hua Wang and Robert James Davies: Airway epithelial cells. Alastair G. Stewart, Darren J. Fernandes, Valentina Kalafatis, Aurora Messina, Claire E. Ravenhall, Ross Vlahos and Kai-Feng Xu: Airway smooth muscle cells. K. H. Banner, D. Spina and C. P. Page: Drugs that reduce airways inflammation. D. M. Kemeny and B. J. O`Connor: T cells in the lung. Index.
Airways disease encompasses a broad range of pathologies including
Bronchial Asthma, Rhinitis, Chronic Obstructive Pulmonary Disease,
Bronchitis, Acute Bronchiolitis, Emphysema and Fibrosing Alveolitis. A
characteristic feature of these diseases is the recruitment and
activation of numerous cell types. Airways inflammation contributes to
the pathophysiology of airways disease...
Inhaltsverzeichnis
Pathological spectrum of airway inflammation.- Role of basophils in airways inflammation.- Platelets.- Neutrophils.- Eosinophils in asthma.- Fibroblasts and myofibroblasts.- Airway macrophages and dendritic cells.- Contribution of endothelial cells to airway inflammation.- Airway epithelial cells.- Airway smooth muscle cells.- Drugs that reduce airways inflammation.- T cells in the lung.
Klappentext
Airways inflammation is a complex biological phenomenon resulting from
the recruitment and activation of numerous cell types. Airways
inflammation contributes to the pathophysiology of airways disease. An
understanding of the mechanisms that regulate inflammatory cell function
is essential for the development of novel anti-inflammatory drugs for
the treatment of common respiratory diseases such as asthma and COPD.
This book provides a collection of valuable reviews on the major
inflammatory cells involved in airways disease and examines the
pharmacology of current anti-inflammatory drugs used in the treatment of
airways disease. Moreover, an insight into the development of emerging
drug therapies is also highlighted.
This book is a must for the library of any researcher or clinician
interested in the pathophysiology of airways disease.
Airways disease encompasses a broad range of pathologies including
Bronchial Asthma, Rhinitis, Chronic Obstructive Pulmonary Disease,
Bronchitis, Acute Bronchiolitis, Emphysema and Fibrosing Alveolitis. A
characteristic feature of these diseases is the recruitment and
activation of numerous cell types. Airways inflammation contributes to
the pathophysiology of airways disease...
