The basic knowledge of cell biology and molecular genetics in oncology is increasingly attracting the interest of clinical oncologists and is close to reaching a helpful application at the bedside. At present, it seems clear that the solution of the cancer problem lies within the comprehension of the intimate mechanisms leading to cell transformation and tumor progression as weIl as of the cancer-host relationship. According to this rationale every achievement in this context could drastically improve both diagnosis and therapy of neoplastic diseases. This={)ook represents the proceedings of the International Conference o~ Cancer: Biological Mechanisms and Clinical Applications, held in Rome on November 16-18, 1992. The meeting was organized by the Centro di Ricerche Oncologiche "Giovanni XXIII" of the Catholic University of Rome and the Consorzio Mario Negri Sud of S. M. Imbaro in collaboration with other colleagues from the Universities of Napoli and Bologna. As organizers and pmticipants to the Conference we think the meeting was a success, as was confirmed by the great interest raised in scientific and academic circles. The book collects contributions from leading scientists in all oncological m·eas ranging from molecular biology to immunology, diagnosis and therapy. The papers are organized into four sections: I - Molecular aspects of cell transformation and growth; II - Membrane receptors and signal transduction; III - Models for new therapeutical strategies; IV - Clinical Applications, following the strategy that chm·acterized the entire meeting: from molecule to bedside.
Molecular aspects of cell transformation and growth.- The Impact of Molecular Genetics on Cancer Research.- Identification of a Chimeric Gene Frequently Activated in Human Thyroid Papillary Carcinomas.- The Role of Tumor Suppressor Genes in Human Cancer Progression.- The Central Role of the IGF-1 Receptor in the Control of Cellular Proliferation.- Loss of TGF-ß Expression is a Critical Component of Malignant Progression in Multistage Carcinogenesis of the Mouse Epidermis.- Structure, Biosynthesis and Biochemical Properties of the HGF/SF Receptor.- Molecular Characterization of Trop-2, a Cell Surface Molecule Highly Expressed by Human Carcinomas — Cloning of the Gene Encoding Trop-2.- Loss of Heterozygosity and Distribution of Alleles at the VNTR Region of the HRAS Gene in Ovarian Carcinoma.- Mg2+ in the Regulation of Ascites Tumor Cell Energy Metabolism.- Effect of Quercetin on Cell Proliferation and Heat Shock Protein Synthesis Induction in K562 Erythroleukemia.- Regulation of MnSOD Expression by Manganese in Tumors.- Membrane receptors and signal transduction.- An Efficient Expression cDNA Cloning Approach to Screen Human Tumors for Oncogenes.- The Roles of Specific Isoforms of Protein Kinase C (PKC) in Signal Transduction, Growth Control and Diacylglycerol Metabolism.- Regulation of Protein Kinase C.- Potential Roles of p21ras in Growth Factor Signalling — An Overview.- p21-ras and p56-lck Mediate The Two Major T-Cell Antigen Receptor Signal Transduction Pathways.- Further Characterization of CDC25 Mm , a Mammalian Activator of p21ras.- MAP Kinase Cascade and the Control of Cell Proliferation.- Accumulation and Mitogenic Activity of Lysophosphatidylinositol in k-ras-Transformed Thyroid Cells.- Activities Involved in the Modulation of the G Protein Endogenous ADP-Ribosylation in Normal and K-ras-Transformed Thyroid Cells.- The Regulation of TNF-? Receptors in Human Osteosarcoma Cells.- Chronic Exposure to the Tumor Promoter TPA Mimics Differentiating Effects of Serum in Primary Cultures of Cerebellar Granules.- Tranillegalscriptional Control by Nuclear Receptors.- Models for new therapeutical strategies.- Therapeutic Opportunities Involving Cellular Oncogenes.- Molecular Analysis of Fine Needle Aspiration Cytologic Specimens from Suspicious Thyroid Nodules.- Tumor-associated Macrophages: Cytokine Regulation and Therapeutic Implications.- Various Cytokines (IL-2, IL-4, IFN-gamma) Show Different Efficiency in Inducing Tumor Rejection.- Adoptive Immunotherapy of Melanoma with Interleukin-2 and Lymphocytes.- GM-CSF Augments the IL-4 Induced Cytotoxic Activity of Human Peripheral Blood Mononuclear Cells in the Presence of the Mouse Monoclonal Antibody 17–1A.- Autologous Bone Marrow Transplantation with Peripheral Stem Cells In vivo Expanded by Chemotherapy and G-CSF.- The Regulatory Subunit of cAMP-Dependent Protein Kinase as a Target for Cancer Diagnosis and Therapy.- Type I Isoform of PKA is Involved in the Control of Cell Proliferation and Oncogene Transformation of Human Mammary Epithelial Cells: Therapeutic Implications.- Modulation of the Cell Response to Hyperthermia by Membrane Perturbating Agents.- MRS Studies on Experimental Tumours Treated with TNF.- Tumor Vaccines — Perspectives and Practice.- Clinical applications.- Tumor Imaging with Radiolabeled Monoclonal Antibodies and Other Specific Ligands.- Evaluation of p53 Overexpression in Bladder Cancer.- Biological Factors and Treatment Decision in Early Breast Cancer.- New Chemotherapeutic Agents: A Selection of Some of the Most Promising New Drugs.- Degradation of 5-Fluorouracil via the Pyrimidine Degradative Pathway.- Folinic Acid and 5-Fluorouracil ± Interferon Alfa-2b in the Treatment of Advanced Colorectal Cancer: Preliminary Results of a Randomized Study.- Pharmacokinetics of Free and Total Platinum Species after Prolonged Venous Infusion of Cisplatin and Concurrent Radiation Therapy for Lung Carcinoma.- The Role of Interferons in the Treatment of Solid Tumors.- Endocrine Treatment of Malignant Disease.- Interactions Between Growth Factors and Oestrogens in Breast Cancer Cells.- Potentiation of the Antitumor Activity of Tamoxifen by Interferons: A Mini-Review.- Vitamin E status is Influenced by ?-3 Polyunsaturated Fatty Acid Supplementation in Patients at Risk for Colon Cancer.- Progress Towards the Clinical Application of Somatic Cell Gene Therapy.- Intraoperative Radiation Therapy: An Overview.
Molecular aspects of cell transformation and growth.- The Impact of Molecular Genetics on Cancer Research.- Identification of a Chimeric Gene Frequently Activated in Human Thyroid Papillary Carcinomas.- The Role of Tumor Suppressor Genes in Human Cancer Progression.- The Central Role of the IGF-1 Receptor in the Control of Cellular Proliferation.- Loss of TGF-ß Expression is a Critical Component of Malignant Progression in Multistage Carcinogenesis of the Mouse Epidermis.- Structure, Biosynthesis and Biochemical Properties of the HGF/SF Receptor.- Molecular Characterization of Trop-2, a Cell Surface Molecule Highly Expressed by Human Carcinomas - Cloning of the Gene Encoding Trop-2.- Loss of Heterozygosity and Distribution of Alleles at the VNTR Region of the HRAS Gene in Ovarian Carcinoma.- Mg2+ in the Regulation of Ascites Tumor Cell Energy Metabolism.- Effect of Quercetin on Cell Proliferation and Heat Shock Protein Synthesis Induction in K562 Erythroleukemia.- Regulation of MnSOD Expression by Manganese in Tumors.- Membrane receptors and signal transduction.- An Efficient Expression cDNA Cloning Approach to Screen Human Tumors for Oncogenes.- The Roles of Specific Isoforms of Protein Kinase C (PKC) in Signal Transduction, Growth Control and Diacylglycerol Metabolism.- Regulation of Protein Kinase C.- Potential Roles of p21ras in Growth Factor Signalling - An Overview.- p21-ras and p56-lck Mediate The Two Major T-Cell Antigen Receptor Signal Transduction Pathways.- Further Characterization of CDC25 Mm , a Mammalian Activator of p21ras.- MAP Kinase Cascade and the Control of Cell Proliferation.- Accumulation and Mitogenic Activity of Lysophosphatidylinositol in k-ras-Transformed Thyroid Cells.- Activities Involved in the Modulation of the G Protein EndogenousADP-Ribosylation in Normal and K-ras-Transformed Thyroid Cells.- The Regulation of TNF-? Receptors in Human Osteosarcoma Cells.- Chronic Exposure to the Tumor Promoter TPA Mimics Differentiating Effects of Serum in Primary Cultures of Cerebellar Granules.- Tranillegalscriptional Control by Nuclear Receptors.- Models for new therapeutical strategies.- Therapeutic Opportunities Involving Cellular Oncogenes.- Molecular Analysis of Fine Needle Aspiration Cytologic Specimens from Suspicious Thyroid Nodules.- Tumor-associated Macrophages: Cytokine Regulation and Therapeutic Implications.- Various Cytokines (IL-2, IL-4, IFN-gamma) Show Different Efficiency in Inducing Tumor Rejection.- Adoptive Immunotherapy of Melanoma with Interleukin-2 and Lymphocytes.- GM-CSF Augments the IL-4 Induced Cytotoxic Activity of Human Peripheral Blood Mononuclear Cells in the Presence of the Mouse Monoclonal Antibody 17-1A.- Autologous Bone Marrow Transplantation with Peripheral Stem Cells In vivo Expanded by Chemotherapy and G-CSF.- The Regulatory Subunit of cAMP-Dependent Protein Kinase as a Target for Cancer Diagnosis and Therapy.- Type I Isoform of PKA is Involved in the Control of Cell Proliferation and Oncogene Transformation of Human Mammary Epithelial Cells: Therapeutic Implications.- Modulation of the Cell Response to Hyperthermia by Membrane Perturbating Agents.- MRS Studies on Experimental Tumours Treated with TNF.- Tumor Vaccines - Perspectives and Practice.- Clinical applications.- Tumor Imaging with Radiolabeled Monoclonal Antibodies and Other Specific Ligands.- Evaluation of p53 Overexpression in Bladder Cancer.- Biological Factors and Treatment Decision in Early Breast Cancer.- New Chemotherapeutic Agents: A Selection of Some of the Most Promising New Drugs.- Degradation of5-Fluorouracil via the Pyrimidine Degradative Pathway.- Folinic Acid and 5-Fluorouracil ± Interferon Alfa-2b in the Treatment of Advanced Colorectal Cancer: Preliminary Results of a Randomized Study.- Pharmacokinetics of Free and Total Platinum Species after Prolonged Venous Infusion of Cisplatin and Concurrent Radiation Therapy for Lung Carcinoma.- The Role of Interferons in the Treatment of Solid Tumors.- Endocrine Treatment of Malignant Disease.- Interactions Between Growth Factors and Oestrogens in Breast Cancer Cells.- Potentiation of the Antitumor Activity of Tamoxifen by Interferons: A Mini-Review.- Vitamin E status is Influenced by ?-3 Polyunsaturated Fatty Acid Supplementation in Patients at Risk for Colon Cancer.- Progress Towards the Clinical Application of Somatic Cell Gene Therapy.- Intraoperative Radiation Therapy: An Overview.
Inhaltsverzeichnis
Molecular aspects of cell transformation and growth.- The Impact of Molecular Genetics on Cancer Research.- Identification of a Chimeric Gene Frequently Activated in Human Thyroid Papillary Carcinomas.- The Role of Tumor Suppressor Genes in Human Cancer Progression.- The Central Role of the IGF-1 Receptor in the Control of Cellular Proliferation.- Loss of TGF-ß Expression is a Critical Component of Malignant Progression in Multistage Carcinogenesis of the Mouse Epidermis.- Structure, Biosynthesis and Biochemical Properties of the HGF/SF Receptor.- Molecular Characterization of Trop-2, a Cell Surface Molecule Highly Expressed by Human Carcinomas - Cloning of the Gene Encoding Trop-2.- Loss of Heterozygosity and Distribution of Alleles at the VNTR Region of the HRAS Gene in Ovarian Carcinoma.- Mg2+ in the Regulation of Ascites Tumor Cell Energy Metabolism.- Effect of Quercetin on Cell Proliferation and Heat Shock Protein Synthesis Induction in K562 Erythroleukemia.- Regulation of MnSOD Expression by Manganese in Tumors.- Membrane receptors and signal transduction.- An Efficient Expression cDNA Cloning Approach to Screen Human Tumors for Oncogenes.- The Roles of Specific Isoforms of Protein Kinase C (PKC) in Signal Transduction, Growth Control and Diacylglycerol Metabolism.- Regulation of Protein Kinase C.- Potential Roles of p21ras in Growth Factor Signalling - An Overview.- p21-ras and p56-lck Mediate The Two Major T-Cell Antigen Receptor Signal Transduction Pathways.- Further Characterization of CDC25 Mm , a Mammalian Activator of p21ras.- MAP Kinase Cascade and the Control of Cell Proliferation.- Accumulation and Mitogenic Activity of Lysophosphatidylinositol in k-ras-Transformed Thyroid Cells.- Activities Involved in the Modulation of the G Protein Endogenous ADP-Ribosylation in Normal and K-ras-Transformed Thyroid Cells.- The Regulation of TNF-? Receptors in Human Osteosarcoma Cells.- Chronic Exposure to the Tumor Promoter TPA Mimics Differentiating Effects of Serum in Primary Cultures of Cerebellar Granules.- Tranillegalscriptional Control by Nuclear Receptors.- Models for new therapeutical strategies.- Therapeutic Opportunities Involving Cellular Oncogenes.- Molecular Analysis of Fine Needle Aspiration Cytologic Specimens from Suspicious Thyroid Nodules.- Tumor-associated Macrophages: Cytokine Regulation and Therapeutic Implications.- Various Cytokines (IL-2, IL-4, IFN-gamma) Show Different Efficiency in Inducing Tumor Rejection.- Adoptive Immunotherapy of Melanoma with Interleukin-2 and Lymphocytes.- GM-CSF Augments the IL-4 Induced Cytotoxic Activity of Human Peripheral Blood Mononuclear Cells in the Presence of the Mouse Monoclonal Antibody 17-1A.- Autologous Bone Marrow Transplantation with Peripheral Stem Cells In vivo Expanded by Chemotherapy and G-CSF.- The Regulatory Subunit of cAMP-Dependent Protein Kinase as a Target for Cancer Diagnosis and Therapy.- Type I Isoform of PKA is Involved in the Control of Cell Proliferation and Oncogene Transformation of Human Mammary Epithelial Cells: Therapeutic Implications.- Modulation of the Cell Response to Hyperthermia by Membrane Perturbating Agents.- MRS Studies on Experimental Tumours Treated with TNF.- Tumor Vaccines - Perspectives and Practice.- Clinical applications.- Tumor Imaging with Radiolabeled Monoclonal Antibodies and Other Specific Ligands.- Evaluation of p53 Overexpression in Bladder Cancer.- Biological Factors and Treatment Decision in Early Breast Cancer.- New Chemotherapeutic Agents: A Selection of Some of the Most Promising New Drugs.- Degradation of 5-Fluorouracil via the Pyrimidine Degradative Pathway.- Folinic Acid and 5-Fluorouracil ± Interferon Alfa-2b in the Treatment of Advanced Colorectal Cancer: Preliminary Results of a Randomized Study.- Pharmacokinetics of Free and Total Platinum Species after Prolonged Venous Infusion of Cisplatin and Concurrent Radiation Therapy for Lung Carcinoma.- The Role of Interferons in the Treatment of Solid Tumors.- Endocrine Treatment of Malignant Disease.- Interactions Between Growth Factors and Oestrogens in Breast Cancer Cells.- Potentiation of the Antitumor Activity of Tamoxifen by Interferons: A Mini-Review.- Vitamin E status is Influenced by ?-3 Polyunsaturated Fatty Acid Supplementation in Patients at Risk for Colon Cancer.- Progress Towards the Clinical Application of Somatic Cell Gene Therapy.- Intraoperative Radiation Therapy: An Overview.
Klappentext
The basic knowledge of cell biology and molecular genetics in oncology is increasingly attracting the interest of clinical oncologists and is close to reaching a helpful application at the bedside. At present, it seems clear that the solution of the cancer problem lies within the comprehension of the intimate mechanisms leading to cell transformation and tumor progression as weIl as of the cancer-host relationship. According to this rationale every achievement in this context could drastically improve both diagnosis and therapy of neoplastic diseases. This={)ook represents the proceedings of the International Conference o~ Cancer: Biological Mechanisms and Clinical Applications, held in Rome on November 16-18, 1992. The meeting was organized by the Centro di Ricerche Oncologiche "Giovanni XXIII" of the Catholic University of Rome and the Consorzio Mario Negri Sud of S. M. Imbaro in collaboration with other colleagues from the Universities of Napoli and Bologna. As organizers and pmticipants to the Conference we think the meeting was a success, as was confirmed by the great interest raised in scientific and academic circles. The book collects contributions from leading scientists in all oncological m·eas ranging from molecular biology to immunology, diagnosis and therapy. The papers are organized into four sections: I - Molecular aspects of cell transformation and growth; II - Membrane receptors and signal transduction; III - Models for new therapeutical strategies; IV - Clinical Applications, following the strategy that chm·acterized the entire meeting: from molecule to bedside.
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