Explores the powerful and versatile g protein-coupled receptors and their application in health and medicine
Features practical methods that are lab-proven and ready to use
Includes expert opinions on the future directions of the rapidly progressing field
G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab.
Authoritative and easy to use, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.
Part I: Genetic Mechanisms of G Protein-Coupled Receptors
1. G Protein-Coupled Receptors: Research and Methods in the Post-Genomic Era
Craig W. Stevens
2. Examining the Dynamic Evolution of G Protein-Coupled Receptors
Claudia Stäubert, Diana Le Duc, and Torsten Schöneberg
3. Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptors
Katja Spiess and Mette M. Rosenkilde
4. Discovery and Function of the Very Large G Protein-Coupled Receptor
Perrin C. White and D. Randy McMillan
5. Functional Evolution of Opioid Family G Protein-Coupled Receptors
Eyal Vardy, Craig W. Stevens, and Bryan L. Roth
6. Investigation of G Protein-Coupled Receptor Function and Regulation Using Antisense
Jonathon Mark Willets and Craig Nash
7. Signalosome Profiling Reveals Allosteric Interactions Between G Protein-Coupled Receptors
Katrin Altosaar, Darlaine Pétrin, Dominic Devost, and Terence E. Hébert
Part II: Genetic Toolbox for G Protein-Coupled Receptor Discovery
8. Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors
Olivia A. Masseck, Melanie D. Mark, and Stefan Herlitze
9. Viral Infection for G Protein-Coupled Receptor Expression in Eukaryotic Cells
Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi
10. Using In Vitro Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptors
Gregory W. Sawyer and Frederick J. Ehlert
11. The CRE Luc Mouse Model for Bioimaging Ligand Activation of G Protein-Coupled Receptors
H. Gregory Polites and Kyriakos D. Economides
12. Inducing Conformational Changes in G Protein-Coupled Receptors by Domain Coupling
Hamiyet Unal and Sadashiva S. Karnik
13. Rescue of Defective G Protein-Coupled Receptor Function by Intermolecular Cooperation
Ashutosh Trehan, Kim Carol Jonas, Ilpo Huhtaniemi, Aylin Carla Hanyaloglu, and Adolfo Rivero-Müller
14. Design of Super-Arrestins for Gene Therapy of Diseases Associated with Excessive Signaling of G Protein-Coupled Receptors
Vsevolod V. Gurevich and Eugenia V. Gurevich
Part III: Genetic Aspects of G Protein-Coupled Receptors in Health and Medicine
15. Importance of G Protein-Coupled Receptor Genetics in Clinical Medicine
Ramakrishna Devaki
16. Pharmacogenomics of G Protein-Coupled Receptor Signaling and Other Pathways in Essential Hypertension
Pedro A. Jose, Van Anthony M. Villar, Matthew R. Weir, and Robin A. Felder
17. Exon Sequencing of G Protein-Coupled Receptor Genes and Perspectives for Disease Treatment
Angeliki Karamitri and Ralf Jockers
18. Gene Therapy Using G Protein-Coupled Receptors for the Treatment of Cardiovascular Disease
Dario Leosco, Grazia D. Femminella, Claudio de Lucia, and Giuseppe Rengo
19. Novel Mechanisms of G Protein-Coupled Receptor Oligomer and Ion Channel Interactions in Nociception
Ajay S. Yekkirala
20. Discovery and Characterization of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors
Marie-Isabelle Garcia, Valeria Fernandez-Vallone, and Gilbert Vassart
21. The Role of G-Protein Coupled Receptors in Adult Neurogenesis
Katie M. Collette, Van A. Doze, and Dianne M. Perez
G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab.
Authoritative and easy to use, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.
G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab.
Authoritative and easy to use, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.
G Protein-Coupled Receptors: Research and Methods in the Post-Genomic Era.- Examining the Dynamic Evolution of G Protein-Coupled Receptors.- Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptors.- Discovery and Function of the Very Large G Protein-Coupled Receptor.- Functional Evolution of Opioid Family G Protein-Coupled Receptors.- Investigation of G Protein-Coupled Receptor Function and Regulation Using Antisense.- Signalosome Profiling Reveals Allosteric Interactions Between G Protein-Coupled Receptors.- Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors.- Viral Infection for G Protein-Coupled Receptor Expression in Eukaryotic Cells.- Using In Vitro Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptors.- The CRE Luc Mouse Model for Bioimaging Ligand Activation of G Protein-Coupled Receptors.- Inducing Conformational Changes in G Protein-Coupled Receptors by Domain Coupling.- Rescue of Defective G Protein-Coupled Receptor Function by Intermolecular Cooperation.- Design of Super-Arrestins for Gene Therapy of Diseases Associated with Excessive Signaling of G Protein-Coupled Receptors.- Importance of G Protein-Coupled Receptor Genetics in Clinical Medicine.- Pharmacogenomics of G Protein-Coupled Receptor Signaling and Other Pathways in Essential Hypertension.- Exon Sequencing of G Protein-Coupled Receptor Genes and Perspectives for Disease Treatment.- Gene Therapy Using G Protein-Coupled Receptors for the Treatment of Cardiovascular Disease.- Novel Mechanisms of G Protein-Coupled Receptor Oligomer and Ion Channel Interactions in Nociception.- Discovery and Characterization of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors.- The Role of G-Protein Coupled Receptors in Adult Neurogenesis.
Inhaltsverzeichnis
Part I: Genetic Mechanisms of G Protein-Coupled Receptors
1. G Protein-Coupled Receptors: Research and Methods in the Post-Genomic Era
Craig W. Stevens
2. Examining the Dynamic Evolution of G Protein-Coupled Receptors
Claudia Stäubert, Diana Le Duc, and Torsten Schöneberg
3. Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptors
Katja Spiess and Mette M. Rosenkilde
4. Discovery and Function of the Very Large G Protein-Coupled Receptor
Perrin C. White and D. Randy McMillan
5. Functional Evolution of Opioid Family G Protein-Coupled Receptors
Eyal Vardy, Craig W. Stevens, and Bryan L. Roth
6. Investigation of G Protein-Coupled Receptor Function and Regulation Using Antisense
Jonathon Mark Willets and Craig Nash
7. Signalosome Profiling Reveals Allosteric Interactions Between G Protein-Coupled Receptors
Katrin Altosaar, Darlaine Pétrin, Dominic Devost, and Terence E. Hébert
Part II: Genetic Toolbox for G Protein-Coupled Receptor Discovery
8. Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors
Olivia A. Masseck, Melanie D. Mark, and Stefan Herlitze
9. Viral Infection for G Protein-Coupled Receptor Expression in Eukaryotic Cells
Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi
10. Using In Vitro Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptors
Gregory W. Sawyer and Frederick J. Ehlert
11. The CRE Luc Mouse Model for Bioimaging Ligand Activation of G Protein-Coupled Receptors
H. Gregory Polites and Kyriakos D. Economides
12. Inducing Conformational Changes in G Protein-Coupled Receptors by Domain Coupling
Hamiyet Unal and Sadashiva S. Karnik
13. Rescue of Defective G Protein-Coupled Receptor Function by Intermolecular Cooperation
Ashutosh Trehan, Kim Carol Jonas, Ilpo Huhtaniemi, Aylin Carla Hanyaloglu, and Adolfo Rivero-Müller
14. Design of Super-Arrestins for Gene Therapy of Diseases Associated with Excessive Signaling of G Protein-Coupled Receptors
Vsevolod V. Gurevich and Eugenia V. Gurevich
Part III: Genetic Aspects of G Protein-Coupled Receptors in Health and Medicine
15. Importance of G Protein-Coupled Receptor Genetics in Clinical Medicine
Ramakrishna Devaki
16. Pharmacogenomics of G Protein-Coupled Receptor Signaling and Other Pathways in Essential Hypertension
Pedro A. Jose, Van Anthony M. Villar, Matthew R. Weir, and Robin A. Felder
17. Exon Sequencing of G Protein-Coupled Receptor Genes and Perspectives for Disease Treatment
Angeliki Karamitri and Ralf Jockers
18. Gene Therapy Using G Protein-Coupled Receptors for the Treatment of Cardiovascular Disease
Dario Leosco, Grazia D. Femminella, Claudio de Lucia, and Giuseppe Rengo
19. Novel Mechanisms of G Protein-Coupled Receptor Oligomer and Ion Channel Interactions in Nociception
Ajay S. Yekkirala
20. Discovery and Characterization of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors
Marie-Isabelle Garcia, Valeria Fernandez-Vallone, and Gilbert Vassart
21. The Role of G-Protein Coupled Receptors in Adult Neurogenesis
Katie M. Collette, Van A. Doze, and Dianne M. Perez
Klappentext
G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab.
Authoritative and easy to use, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.
Explores the powerful and versatile g protein-coupled receptors and their application in health and medicine
Features practical methods that are lab-proven and ready to use
Includes expert opinions on the future directions of the rapidly progressing field
Includes supplementary material: sn.pub/extras
