Collects comprehensive reviews written by leading scientists in the field
Provides up-to-date techniques for detection and imaging of drug transporters
Offers strategies to evaluate the efficacy of resistance reversal agents
Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .
1. Multidrug Resistance in CancerBruce C. Baguley2. Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug TargetsWouter B. Nagengast, Thijs H. Oude Munnink, Eli C.F. Dijkers, Geke A.P. Hospers, Adrienne H. Brouwers, Carolien P. Schröder, Marjolijn Lub-de Hooge, and Elisabeth G.E. de Vries3. Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast CancerSven Rottenberg, Marina Pajic, and Jos Jonkers4. Mechanisms of Multidrug Resistance in CancerJean-Pierre Gillet and Michael M. Gottesman5. Molecular Mechanisms of Drug Resistance in Single-Step and Multi-Step Drug-Selected Cancer CellsAnna Maria Calcagno and Suresh V. Ambudkar6. Pharmacogenetics of ATP-Binding Cassette Transporters and Clinical ImplicationsIngolf Cascorbi and Sierk Haenisch7. Flow Cytometric Evaluation of Multidrug Resistance ProteinsAdorjan Aszalos and Barbara J. Taylor8. Targeted Chemotherapy in Drug Resistant Tumors and Noninvasive Imaging of P-Glycoprotein-Mediated Functional Transport in Cancer Jothilingam Sivapackiam, Seth T. Gammon, Scott E. Harpstrite, and Vijay Sharma9. Epigenetic Regulation of Multidrug Resistance 1 Gene Expression: Profiling CpG Methylation Status Using Bisulphite SequencingEmma K. Baker and Assam El-Osta10. Expression and Function of P-Glycoprotein in Normal Tissues: Effect on PharmacokineticsFrantisek Staud, Martina Ceckova, Stanislav Micuda, and Petr Pavek11. Molecular Mechanism of ATP-Dependent Solute Transport by Multidrug Resistance-Associated Protein 1Xiu-bao Chang12. Impact of Breast Cancer Resistance Protein on Cancer Treatment OutcomesDouglas D. Ross and Takeo Nakanishi13. Drug Ratio-Dependent Antagonism: A NewCategory of Multidrug Resistance and Strategies for Its CircumventionTroy O. Harasym, Barry D. Liboiron, and Lawrence D. Mayer14. Reversing Agents for ATP-Binding Cassette Drug TransportersChow H. Lee15. Overcoming Multidrug Resistance in Cancer: Clinical Studies of P-Glycoprotein InhibitorsHelen M. Coley16. Pharmacokinetic and Pharmacodynamic Implications of P-Glycoprotein ModulationJeannie M. Padowski and Gary M. Pollack17. Examination of CYP3A and P-Glycoprotein-Mediated Drug-Drug Interactions Using Animal ModelsPunit H. Marathe and A. David Rodrigues18. Generating Inhibitors of P-Glycoprotein: Where to, Now?Emily Crowley, Christopher A. McDevitt, and Richard Callaghan19. Immunosuppressors as Multidrug Resistance Reversal AgentsHamid Morjani and Claudie Madoulet20. Overcoming Multidrug Resistance by RNA InterferenceAlexandra Stege, Andrea Krühn, and Hermann Lage21. Circumventing Tumor Resistance to Chemotherapy by NanotechnologyXing-Jie Liang, Chunying Chen, Yuliang Zhao, and Paul C. Wang
With the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein, to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The extensive volume also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression, as well as techniques for detection and imaging of drug transporters, methods for investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed deillegalscription and implementation advice that is crucial for getting optimal results.
Authoritative and cutting-edge, Multi-Drug Resistance in Cancer offers a state-of-art collection of reviews and methods for both basic and clinician investigators who are interested in the vital study of cancer multi-drug resistance mechanisms and reversal strategies.
From the reviews:
"This book uses cancer as the focus to discuss both the mechanistic events causing multi-drug resistance and the potential ways to mitigate it. ... In summary, this book provides a good overview of the development and treatment of multi-drug resistance in cancer. ... each individual chapter covers a specific area in an easy-to-read manner, which should leave the reader with a better understanding of the topic.” (Nick Plant, BTS Newsletter, Issue 37, Winter, 2010)
"The topics covered in this 21-chapter volume have been provided by leading experts in the field. ... The chapters are generally well written and clear. ... This provides a full picture on what is going on in this exciting field. ... this book offers a comprehensive survey of the fields of knowledge and research concerning cancer multi-drug resistance mechanisms and reversal strategies. In this way, it is relevant for basic and clinical investigators, for the less experienced and mature researchers ... .” (Rolf W. Hartmann, ChemMedChem, Vol. 6 (3), 2011)
The efficacy of chemotherapeutic management of cancer is often severely limited. This book provides comprehensive reviews of multidrug resistance mechanisms. It includes up-to-date techniques for detection and imaging of drug transporters.
Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 MultidrugResistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .
Multidrug Resistance in Cancer.- Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets.- Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast Cancer.- Mechanisms of Multidrug Resistance in Cancer.- Molecular Mechanisms of Drug Resistance in Single-Step and Multi-Step Drug-Selected Cancer Cells.- Pharmacogenetics of ATP-Binding Cassette Transporters and Clinical Implications.- Flow Cytometric Evaluation of Multidrug Resistance Proteins.- Targeted Chemotherapy in Drug-Resistant Tumors, Noninvasive Imaging of P-Glycoprotein-Mediated Functional Transport in Cancer, and Emerging Role of Pgp in Neurodegenerative Diseases.- Epigenetic Regulation of Multidrug Resistance 1 Gene Expression: Profiling CpG Methylation Status Using Bisulphite Sequencing.- Expression and Function of P-Glycoprotein in Normal Tissues: Effect on Pharmacokinetics.- Molecular Mechanism of ATP-Dependent Solute Transport by Multidrug Resistance-Associated Protein 1.- Impact of Breast Cancer Resistance Protein on Cancer Treatment Outcomes.- Drug Ratio-Dependent Antagonism: A New Category of Multidrug Resistance and Strategies for Its Circumvention.- Reversing Agents for ATP-Binding Cassette Drug Transporters.- Overcoming Multidrug Resistance in Cancer: Clinical Studies of P-Glycoprotein Inhibitors.- Pharmacokinetic and Pharmacodynamic Implications of P-Glycoprotein Modulation.- Examination of CYP3A and P-Glycoprotein-Mediated Drug-Drug Interactions Using Animal Models.- Generating Inhibitors of P-Glycoprotein: Where to, Now?.- Immunosuppressors as Multidrug Resistance Reversal Agents.- Overcoming Multidrug Resistance by RNA Interference.- Circumventing Tumor Resistance to Chemotherapy by Nanotechnology.
From the reviews:
"This book uses cancer as the focus to discuss both the mechanistic events causing multi-drug resistance and the potential ways to mitigate it. ... In summary, this book provides a good overview of the development and treatment of multi-drug resistance in cancer. ... each individual chapter covers a specific area in an easy-to-read manner, which should leave the reader with a better understanding of the topic." (Nick Plant, BTS Newsletter, Issue 37, Winter, 2010)
"The topics covered in this 21-chapter volume have been provided by leading experts in the field. ... The chapters are generally well written and clear. ... This provides a full picture on what is going on in this exciting field. ... this book offers a comprehensive survey of the fields of knowledge and research concerning cancer multi-drug resistance mechanisms and reversal strategies. In this way, it is relevant for basic and clinical investigators, for the less experienced and mature researchers ... ." (Rolf W. Hartmann, ChemMedChem, Vol. 6 (3), 2011)
Inhaltsverzeichnis
1. Multidrug Resistance in Cancer
Bruce C. Baguley
2. Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets
Wouter B. Nagengast, Thijs H. Oude Munnink, Eli C.F. Dijkers, Geke A.P. Hospers, Adrienne H. Brouwers, Carolien P. Schröder, Marjolijn Lub-de Hooge, and Elisabeth G.E. de Vries
3. Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast Cancer
Sven Rottenberg, Marina Pajic, and Jos Jonkers
4. Mechanisms of Multidrug Resistance in Cancer
Jean-Pierre Gillet and Michael M. Gottesman
5. Molecular Mechanisms of Drug Resistance in Single-Step and Multi-Step Drug-Selected Cancer Cells
Anna Maria Calcagno and Suresh V. Ambudkar
6. Pharmacogenetics of ATP-Binding Cassette Transporters and Clinical Implications
Ingolf Cascorbi and Sierk Haenisch
7. Flow Cytometric Evaluation of Multidrug Resistance Proteins
Adorjan Aszalos and Barbara J. Taylor
8. Targeted Chemotherapy in Drug Resistant Tumors and Noninvasive Imaging of P-Glycoprotein-Mediated Functional Transport in Cancer
Jothilingam Sivapackiam, Seth T. Gammon, Scott E. Harpstrite, and Vijay Sharma
9. Epigenetic Regulation of Multidrug Resistance 1 Gene Expression: Profiling CpG Methylation Status Using Bisulphite Sequencing
Emma K. Baker and Assam El-Osta
10. Expression and Function of P-Glycoprotein in Normal Tissues: Effect on Pharmacokinetics
Frantisek Staud, Martina Ceckova, Stanislav Micuda, and Petr Pavek
11. Molecular Mechanism of ATP-Dependent Solute Transport by Multidrug Resistance-Associated Protein 1
Xiu-bao Chang
12. Impact of Breast Cancer Resistance Protein on Cancer Treatment Outcomes
Douglas D. Ross and Takeo Nakanishi
13. Drug Ratio-Dependent Antagonism: A NewCategory of Multidrug Resistance and Strategies for Its Circumvention
Troy O. Harasym, Barry D. Liboiron, and Lawrence D. Mayer
14. Reversing Agents for ATP-Binding Cassette Drug Transporters
Chow H. Lee
15. Overcoming Multidrug Resistance in Cancer: Clinical Studies of P-Glycoprotein Inhibitors
Helen M. Coley
16. Pharmacokinetic and Pharmacodynamic Implications of P-Glycoprotein Modulation
Jeannie M. Padowski and Gary M. Pollack
17. Examination of CYP3A and P-Glycoprotein-Mediated Drug-Drug Interactions Using Animal Models
Punit H. Marathe and A. David Rodrigues
18. Generating Inhibitors of P-Glycoprotein: Where to, Now?
Emily Crowley, Christopher A. McDevitt, and Richard Callaghan
19. Immunosuppressors as Multidrug Resistance Reversal Agents
Hamid Morjani and Claudie Madoulet
20. Overcoming Multidrug Resistance by RNA Interference
Alexandra Stege, Andrea Krühn, and Hermann Lage
21. Circumventing Tumor Resistance to Chemotherapy by Nanotechnology
Xing-Jie Liang, Chunying Chen, Yuliang Zhao, and Paul C. Wang
Klappentext
Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 MultidrugResistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .
Collects comprehensive reviews written by leading scientists in the field
rn
Provides up-to-date techniques for detection and imaging of drug transporters
rn
Offers strategies to evaluate the efficacy of resistance reversal agents
rn
