Provides researchers and clinicians with clear methodologies for conducting translational bench-to-bedside studies through these detailed animal models
Features practical and easy-to-use protocols that are ready for the lab
Includes expert tips and concrete implementation advice to ensure successful results
New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art "Omics approaches” and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful Methods in Molecular Biology™ series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Thorough and easily applicable,
Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.
Part I: Overview of the Animal Research in Psychiatric Illness and Substance Abuse
1. New Frontiers in Animal Research of Psychiatric Illness
Arie Kaffman and John J. Krystal
2. Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview
Scott Edwards and George F. Koob
3. Qualitative Vs. Quantitative Methods in Psychiatric Research
Mahdi Razafsha, Hura Behforuzi, Hassan Azari, Zhiqun Zhang,Kevin K. Wang, Firas H. Kobeissy, and Mark S. Gold
Part II: Methods in Animal Models of Psychiatric Illness
4. Animal Models of Self-Injurious Behavior: An Overview
Darragh P. Devine
5. Rodent Models of Adaptive Decision Making
Alicia Izquierdo and Annabelle M. Belcher
6. Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis
Ying Xu, Philip A. Barish, Jianchun Pan, William O. Ogle, and James M. O´Donnell
7. Modeling Depression in Animal Models
David H. Overstreet
8. Behavioral Model for Assessing Cognitive Decline
Michael Guidi and Thomas C. Foster
9. The Pemoline Model of Self-Injurious Behavior
Darragh P. Devine
10. Modeling Risky Decision Making in Rodents
Nicholas W. Simon and Barry Setlow
11. Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes
Abdelkader Ennaceur
12. An Animal Model to Study the Molecular Basis of Tardive Dyskinesia
Mahendra Bishnoi and Ravneet K. Boparai
Part III: Methods in Animal Models of Substance Abuse
13. Models of Chronic Alcohol Exposure and Dependence
Darin J. Knapp and George R. Breese
14. Rat Models of Prenatal and Adolescent Cannabis Exposure
Jennifer A. DiNieri and Yasmin L. Hurd
15. Modeling Nicotine Addiction in Rats
Stephanie Caille, Kelly Clemens, Luis Stinus, and Martine Cador
16. Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal
Rayna M. Bauzo and Adrie W. Bruijnzeel
17. Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms
Firas H. Kobeissy, Jeremiah D. Mitzelfelt, Irina Fishman, Drake Morgan, Roger Gaskins, Zhiqun Zhang, Mark S Gold, and Kevin Wang
18. Cocaine Self-Administration in Rats: Hold Down Procedures
Benjamin A. Zimmer and David C.S. Roberts
19. Cocaine Self-Administration in Rats: Discrete Trials Procedures
Carson V. Dobrin and David C.S. Roberts
20. Cocaine Self-Administration in Rats: Threshold Procedures
Erik B. Oleson and David C.S. Roberts
21. Assessing Locomotor-Stimulating Effects of Cocaine in Rodents
Drake Morgan, Jameson P. DuPree, Alex D. Bibbey, and Glen M. Sizemore
22. Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure
Joy Guingab-Cagmat, Rayna M. Bauzo, Adrie W. Bruijnzeel, Kevin Wang, Mark S. Gold, and Firas H. Kobeissy
Part IV: Methods in Animal Models of Eating Disorders
23. Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight
Nicole M. Avena, Miriam E. Bocarsly, and Bartley G. Hoebel
24. Animal Models of Overeating
Neil E. Rowland
25. The Activity-Based Anorexia Mouse Model
Stephanie J. Klenotich and Stephanie C. Dulawa
Part V: Biomarkers, Neuroendocrine and Inflammatory Profiles Relevant to Neuropsychiatric Disorders
26. Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models
Amy S. Kohtz and Cheryl A. Frye
27. Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders
John M. Petitto, Zhi Huang, Danielle Meola, Grace K. Ha, and Daniel Dauer
28. Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines
Hiroyuki Nawa and Kiyofumi Yamada
29. P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD)
Lei Zhang and He Li
Part VI: "Omics” Analysis and Systems Biology Applications in Psychiatric Disorders
30. Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure
Antoniette M. Maldonado-Devincci, Stanley M. Stevens, Jr., and Cheryl L. Kirstein
31. Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders
Julia S. Gelman, Jonathan Wardman, Vadiraja B. Bhat, Fabio C. Gozzo, and Lloyd D. Fricker
32. ADHD Animal Model Characterization: Tranillegalscriptomics and Proteomics Analyses
Yoshinori Masuo, Junko Shibato, and Randeep Rakwal
33. Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics
Michaela D. Filiou and Christoph W. Turck
34. Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research
Pietro Paolo Sanna, Vez Repunte-Canonigo, and Alessandro Guidotti
35. Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia
Bin Liu, David S. Barber, and Stanley M. Stevens, Jr.
36. Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations
Felix Tretter and Peter J. Gebicke-Haerter
37. Data Mining in Psychiatric Research
Diego Tovar, Eduardo Cornejo, Petros Xanthopoulos, Mario R. Guarracino, and Panos M. Pardalos
From the reviews:
"This is a comprehensive compilation of in vivo and in vitro neuropsychiatric research methods and protocols on animal models and cutting-edge techniques in the wide spectrum of psychiatric illnesses. ... It is written for graduates, postdoctoral workers, and established scientists working on behavioral and molecular neuropsychiatric research. ... The detailed methods and protocols make this a quality book for any researcher in the field of neuroscience and psychiatry.” (Valerie E. Mathis-Allen, Doody´s Book Reviews, May, 2012)
Opening with a review of animal research in psychiatric illness and substance abuse, this book discusses modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response and other topics.
New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art "Omics approaches" and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful Methods in Molecular Biology(TM) series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Thorough and easily applicable,
Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.
New Frontiers in Animal Research of Psychiatric Illness.- Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview.- Qualitative Vs. Quantitative Methods in Psychiatric Research.- Animal Models of Self-Injurious Behavior: An Overview.- Rodent Models of Adaptive Decision Making.- Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis.- Modeling Depression in Animal Models.- Behavioral Model for Assessing Cognitive Decline.- The Pemoline Model of Self-Injurious Behavior.- Modeling Risky Decision Making in Rodents.- Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes.- An Animal Model to Study the Molecular Basis of Tardive Dyskinesia.- Models of Chronic Alcohol Exposure and Dependence.- Rat Models of Prenatal and Adolescent Cannabis Exposure.- Modeling Nicotine Addiction in Rats.- Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal.- Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms.- Cocaine Self-Administration in Rats: Hold Down Procedures.- Cocaine Self-Administration in Rats: Discrete Trials Procedures.- Cocaine Self-Administration in Rats: Threshold Procedures.- Assessing Locomotor-Stimulating Effects of Cocaine in Rodents.- Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure.- Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight.- Animal Models of Overeating.- The Activity-Based Anorexia Mouse Model.- Dissociating Behavioral, Autonomic,and Neuroendocrine Effects of Androgen Steroids in Animal Models.- Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders.- Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines.- P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD).- Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure.- Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders.- ADHD Animal Model Characterization: Tranillegalscriptomics and Proteomics Analyses.- Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics.- Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research.- Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia.- Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations.- Data Mining in Psychiatric Research.
From the reviews:
"This is a comprehensive compilation of in vivo and in vitro neuropsychiatric research methods and protocols on animal models and cutting-edge techniques in the wide spectrum of psychiatric illnesses. ... It is written for graduates, postdoctoral workers, and established scientists working on behavioral and molecular neuropsychiatric research. ... The detailed methods and protocols make this a quality book for any researcher in the field of neuroscience and psychiatry." (Valerie E. Mathis-Allen, Doody's Book Reviews, May, 2012)
Inhaltsverzeichnis
Part I: Overview of the Animal Research in Psychiatric Illness and Substance Abuse
1. New Frontiers in Animal Research of Psychiatric Illness
Arie Kaffman and John J. Krystal
2. Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview
Scott Edwards and George F. Koob
3. Qualitative Vs. Quantitative Methods in Psychiatric Research
Mahdi Razafsha, Hura Behforuzi, Hassan Azari, Zhiqun Zhang,Kevin K. Wang, Firas H. Kobeissy, and Mark S. Gold
Part II: Methods in Animal Models of Psychiatric Illness
4. Animal Models of Self-Injurious Behavior: An Overview
Darragh P. Devine
5. Rodent Models of Adaptive Decision Making
Alicia Izquierdo and Annabelle M. Belcher
6. Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis
Ying Xu, Philip A. Barish, Jianchun Pan, William O. Ogle, and James M. O'Donnell
7. Modeling Depression in Animal Models
David H. Overstreet
8. Behavioral Model for Assessing Cognitive Decline
Michael Guidi and Thomas C. Foster
9. The Pemoline Model of Self-Injurious Behavior
Darragh P. Devine
10. Modeling Risky Decision Making in Rodents
Nicholas W. Simon and Barry Setlow
11. Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes
Abdelkader Ennaceur
12. An Animal Model to Study the Molecular Basis of Tardive Dyskinesia
Mahendra Bishnoi and Ravneet K. Boparai
Part III: Methods in Animal Models of Substance Abuse
13. Models of Chronic Alcohol Exposure and Dependence
Darin J. Knapp and George R. Breese
14. Rat Models of Prenatal and Adolescent Cannabis Exposure
Jennifer A. DiNieri and Yasmin L. Hurd
15. Modeling Nicotine Addiction in Rats
Stephanie Caille, Kelly Clemens, Luis Stinus, and Martine Cador
16. Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal
Rayna M. Bauzo and Adrie W. Bruijnzeel
17. Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms
Firas H. Kobeissy, Jeremiah D. Mitzelfelt, Irina Fishman, Drake Morgan, Roger Gaskins, Zhiqun Zhang, Mark S Gold, and Kevin Wang
18. Cocaine Self-Administration in Rats: Hold Down Procedures
Benjamin A. Zimmer and David C.S. Roberts
19. Cocaine Self-Administration in Rats: Discrete Trials Procedures
Carson V. Dobrin and David C.S. Roberts
20. Cocaine Self-Administration in Rats: Threshold Procedures
Erik B. Oleson and David C.S. Roberts
21. Assessing Locomotor-Stimulating Effects of Cocaine in Rodents
Drake Morgan, Jameson P. DuPree, Alex D. Bibbey, and Glen M. Sizemore
22. Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure
Joy Guingab-Cagmat, Rayna M. Bauzo, Adrie W. Bruijnzeel, Kevin Wang, Mark S. Gold, and Firas H. Kobeissy
Part IV: Methods in Animal Models of Eating Disorders
23. Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight
Nicole M. Avena, Miriam E. Bocarsly, and Bartley G. Hoebel
24. Animal Models of Overeating
Neil E. Rowland
25. The Activity-Based Anorexia Mouse Model
Stephanie J. Klenotich and Stephanie C. Dulawa
Part V: Biomarkers, Neuroendocrine and Inflammatory Profiles Relevant to Neuropsychiatric Disorders
26. Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models
Amy S. Kohtz and Cheryl A. Frye
27. Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders
John M. Petitto, Zhi Huang, Danielle Meola, Grace K. Ha, and Daniel Dauer
28. Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines
Hiroyuki Nawa and Kiyofumi Yamada
29. P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD)
Lei Zhang and He Li
Part VI: "Omics" Analysis and Systems Biology Applications in Psychiatric Disorders
30. Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure
Antoniette M. Maldonado-Devincci, Stanley M. Stevens, Jr., and Cheryl L. Kirstein
31. Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders
Julia S. Gelman, Jonathan Wardman, Vadiraja B. Bhat, Fabio C. Gozzo, and Lloyd D. Fricker
32. ADHD Animal Model Characterization: Tranillegalscriptomics and Proteomics Analyses
Yoshinori Masuo, Junko Shibato, and Randeep Rakwal
33. Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics
Michaela D. Filiou and Christoph W. Turck
34. Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research
Pietro Paolo Sanna, Vez Repunte-Canonigo, and Alessandro Guidotti
35. Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia
Bin Liu, David S. Barber, and Stanley M. Stevens, Jr.
36. Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations
Felix Tretter and Peter J. Gebicke-Haerter
37. Data Mining in Psychiatric Research
Diego Tovar, Eduardo Cornejo, Petros Xanthopoulos, Mario R. Guarracino, and Panos M. Pardalos
Klappentext
New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art ¿Omics approaches¿ and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful Methods in Molecular Biology¿ series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.n Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.
Provides researchers and clinicians with clear methodologies for conducting translational bench-to-bedside studies through these detailed animal models
Features practical and easy-to-use protocols that are ready for the lab
Includes expert tips and concrete implementation advice to ensure successful results
Includes supplementary material: sn.pub/extras
