Part I. Antimutagens Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane Thomas W. Kensler and Paul Talalay Chemoprevention by Isothiocyanates Stephen S. Hecht Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D'Agostini, Maria Bagnasco, and Roumen Balansky Modifiers of Cytochrome(s) P450 John DiGiovanni and Heather E. Kleiner Part II. Antiinflammatories Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism Gary B. Gordon, Gary J. Kelloff, and Caroline C. Sigman Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention Raymond N. DuBois Lipoxygenases as Targets for Cancer Prevention Susan M. Fischer and Russell D. Klein Inducible Nitric Oxide Synthase as a Target for Chemoprevention Lorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, and Curtis C. Harris Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil Timothy S. Wiedmann and Lee W. Wattenberg Chemoprevention of Cancer by Curcumin Bandaru S. Reddy and Chinthalapally V. Rao Prostacyclin and Lung Cancer Chemoprevention Robert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, and Mark W. Geraci Part III. Nuclear Receptor Superfamily Nuclear Receptor Superfamily: Targets for Chemoprevention Julia A. Lawrence and Kapil Dhingra A. Antiandrogens Prostate Cancer Chemoprevention: 5a-Reductase Inhibitors Jennifer E. Drisko and Siu-Long Yao Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer Mark S. Chapman,William Y. Chang, Andrés Negro-Vilar, and Jeffrey N. Miner B. Antiestrogens Aromatase Inhibitors as Chemopreventives of Breast Cancer Mitchell Dowsett and Judy E. Garber Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators Carolyn L. Smith C. Natural Vitamin D and Synthetic Analogs Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs Kathryn Z. Guyton, Thomas W. Kensler, and Gary H. Posner D. Retinoids The Retinoids and Cancer Chemoprevention Sutisak Kitareewan, Ian Pitha-Rowe, Yan Ma, Sarah J. Freemantle, and Ethan Dmitrovsky E. Dehydroepiandrosterone and Structural Analogs Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs Arthur G. Schwartz and Laura L. Pashko Part IV. Signal Transduction Modulators ras Oncogene Inhibitors Nancy E. Kohl The Potential of EGFR-Targeted Agents in Cancer Prevention Steven D. Averbuch and Fadlo R. Khuri Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors Paul Workman Therapeutic Strategies Targeting Polyamines Debora L. Kramer and Eugene W. Gerner The Role of Phytoestrogens as Cancer Prevention Agents Stephen Barnes and Coral A. Lamartiniere Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids Pamela L. Crowell and Michael N. Gould Development of an Inhibitor of raf Kinase Frank McCormick Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention Alessandro Sgambato and I. Bernard Weinstein Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy Melissa K. Reeder, Rifat Pamakcu, I. Bernard Weinstein, Kirk Hoffman, and W. Joseph
Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemopreventive Agents, leading researchers in the discovery and development of chemopreventives comprehensively survey all aspects of these emerging therapeutics. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The classes vary widely in terms of their stages of development as chemopreventives and include both extensively studied groups and those with recently identified potential based on such mechanistic data as protein kinase inhibition. Attention is also devoted to nutriceuticals (food-derived agents) because of their high promise for prevention in healthy populations. The overall focus is on molecular targets and mechanisms. A second volume, Strategies for Cancer Chemoprevention, describes the exciting methodologies that are accelerating progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs.
"...a comprehensive review of seizures...a wealth of information." - British Journal of Anesthesiology
"...a valuable addition to any library in a lboratory researching/developing oncology products..." - BTS Newsletter
"...provides a comprehensive reference survey for basic researchers, pharmacologists and clinical oncologists...a must for everyone involved in chemoprevention research." - Annals of Oncology
I. Antimutagens.- 1 Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane.- 2 Chemoprevention by Isothiocyanates.- 3 Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine.- 4 Modifiers of Cytochrome(s) P450.- II. Antiinflammatories.- 5 Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism.- 6 Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention.- 7 Lipoxygenases as Targets for Cancer Prevention.- 8 Inducible Nitric Oxide Synthase as a Target for Chemoprevention.- 9 Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil.- 10 Chemoprevention of Cancer by Curcumin.- 11 Prostacyclin and Lung Cancer Chemoprevention.- III. Nuclear Receptor Superfamily.- 12 Nuclear Receptor Superfamily: Targets for Chemoprevention.- 13 Prostate Cancer Chemoprevention: S?-Reductase Inhibitors.- 14 Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer.- 15 Aromatase Inhibitors as Chemopreventives of Breast Cancer.- 16 Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators.- 17 Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs.- 18 The Retinoids and Cancer Chemoprevention.- 19 Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs.- IV. Signal Transduction Modulators.- 20 ras Oncogene Inhibitors.- 21 The Potential of EGFR-Targeted Agents in Cancer Prevention.- 22 Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors.- 23 Therapeutic Strategies Targeting Polyamines.- 24 The Role of Phytoestrogens as CancerPrevention Agents.- 25 Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids.- 26 Development of an Inhibitor of raf Kinase.- 27 Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention.- 28 Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy.- V. Antioxidants, Vitamins, and Minerals.- 29 Chemoprevention by Fruit Phenolic Compounds.- 30 Tea Polyphenols as Cancer Chemopreventive Agents.- 31 Vitamin E as a Cancer Chemopreventive Agent.- 32 Vitamin C as a Cancer Chemopreventive Agent.- 33 Carotenoids.- 34 Lycopene, a Dietary Cancer Chemopreventive Agent.- 35 Not All Chemopreventive Selenium Compounds are Created Equal.- 36 Calcium.- 37 Folate and Cancer Chemoprevention.- 38 Conjugated Linoleic Acid as a Tumor Preventive Agent.- 39 Chemopreventive Effects of Omega-3 Fatty Acids.- VI. Agents Targeting Biological Processes Important in Cancer.- 40 Tumor Angiogenesis as a Target for Early Intervention and Cancer Prevention.- 41 Proteasome Inhibitors in Cancer Therapy.- 42 Modulation of DNA Methylation for the Treatment and Prevention of Cancer.- 43 Targeting Histone Deacetylase as a Strategy for Cancer Prevention.
"...a comprehensive review of seizures...a wealth of information." - British Journal of Anesthesiology
"...a valuable addition to any library in a lboratory researching/developing oncology products..." - BTS Newsletter
"...provides a comprehensive reference survey for basic researchers, pharmacologists and clinical oncologists...a must for everyone involved in chemoprevention research." - Annals of Oncology
Inhaltsverzeichnis
Part I. Antimutagens
Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane
Thomas W. Kensler and Paul Talalay
Chemoprevention by Isothiocyanates
Stephen S. Hecht
Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine
Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D'Agostini, Maria Bagnasco, and Roumen Balansky
Modifiers of Cytochrome(s) P450
John DiGiovanni and Heather E. Kleiner
Part II. Antiinflammatories
Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism
Gary B. Gordon, Gary J. Kelloff, and Caroline C. Sigman
Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention
Raymond N. DuBois
Lipoxygenases as Targets for Cancer Prevention
Susan M. Fischer and Russell D. Klein
Inducible Nitric Oxide Synthase as a Target for Chemoprevention
Lorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, and Curtis C. Harris
Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil
Timothy S. Wiedmann and Lee W. Wattenberg
Chemoprevention of Cancer by Curcumin
Bandaru S. Reddy and Chinthalapally V. Rao
Prostacyclin and Lung Cancer Chemoprevention
Robert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, and Mark W. Geraci
Part III. Nuclear Receptor Superfamily
Nuclear Receptor Superfamily: Targets for Chemoprevention
Julia A. Lawrence and Kapil Dhingra
A. Antiandrogens
Prostate Cancer Chemoprevention: 5a-Reductase Inhibitors
Jennifer E. Drisko and Siu-Long Yao
Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer
Mark S. Chapman,William Y. Chang, Andrés Negro-Vilar, and Jeffrey N. Miner
B. Antiestrogens
Aromatase Inhibitors as Chemopreventives of Breast Cancer
Mitchell Dowsett and Judy E. Garber
Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators
Carolyn L. Smith
C. Natural Vitamin D and Synthetic Analogs
Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs
Kathryn Z. Guyton, Thomas W. Kensler, and Gary H. Posner
D. Retinoids
The Retinoids and Cancer Chemoprevention
Sutisak Kitareewan, Ian Pitha-Rowe, Yan Ma, Sarah J. Freemantle, and Ethan Dmitrovsky
E. Dehydroepiandrosterone and Structural Analogs
Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs
Arthur G. Schwartz and Laura L. Pashko
Part IV. Signal Transduction Modulators
ras Oncogene Inhibitors
Nancy E. Kohl
The Potential of EGFR-Targeted Agents in Cancer Prevention
Steven D. Averbuch and Fadlo R. Khuri
Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors
Paul Workman
Therapeutic Strategies Targeting Polyamines
Debora L. Kramer and Eugene W. Gerner
The Role of Phytoestrogens as Cancer Prevention Agents
Stephen Barnes and Coral A. Lamartiniere
Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids
Pamela L. Crowell and Michael N. Gould
Development of an Inhibitor of raf Kinase
Frank McCormick
Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention
Alessandro Sgambato and I. Bernard Weinstein
Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy
Melissa K. Reeder, Rifat Pamakcu, I. Bernard Weinstein, Kirk Hoffman, and W. Joseph
Klappentext
A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Includes supplementary material: sn.pub/extras
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