Significant improvements in lifestyle and medical science are leading to an ever increasing elderly population in the United States and other developed nations. The U.S census bureau estimates that the number of people over 65 will nearly double by 2030, and that the elderly will comprise nearly one-fifth of the world's entire population within the next 20 years. In Animal Models of Human Cognitive Aging, Jennifer Bizon, Alisa Woods, and a panel of international authorities comprehensively discuss the use of animal models as a tool for understanding cognitive changes associated with the aging process. The book provides substantive background on the newest and most widely used animal models in studies of cognition and aging, while detailing the normal and pathological processes of brain aging of humans in relation to those models. Additional chapters comprehensively review frontal cortical deficits and executive function in primates as related to humans, and the use of transgenic modulation in mice to model Alzheimer's and other age-related diseases. Groundbreaking and authoritative, Animal Models of Human Cognitive Aging provides a valuable resource for Neuroscientists, Gerontological Scientists and all aging medicine researchers, while serving as a primer for understanding current brain aging studies.
Chapter 1. Normal and Pathological Aging - From Animals to Humans Nicole C. Berchtold and Carl W. Cotman Chapter 2. Non-Human Primate Models of Cognitive Aging Agnès Lacreuse and James G. Herndon Chapter 3. Age-related Effects on Prefrontal Cortical Systems: Translating Between Rodents, Nonhuman Primates, and Humans Mark G. Baxter Chapter 4. Comparison of Different Cognitive Rat Models of Human Aging Candi LaSarge and Michelle Nicolle Chapter 5. Mouse Models of Cognitive Aging: Behavioral Tasks and Neural Substrates Michael E. Calhoun Chapter 6. Impact of Aß and Tau on Cognition in Mouse Models of Alzheimer's Disease Maya A. Koike, Kristoffer Myczek, Kim N. Green and Frank M. LaFerla Chapter 7. Hormonal Influences on Brain Aging and Age-Related Cognitive Decline Danielle K Lewis and Farida Sohrabji Chapter 8. Timing Deficits in Aging and Neuropathology Fuat Balci, Warren H. Meck, Holly Moor, and Dani Brunner
From the reviews:
"This multiauthored series of essays describe animal models of human cognitive aging. ... The audience includes the community, working in neurobiology and interested in age-related changes in brain function. The authors are all experts in this area. ... Everyone interested in experimental models of the aging of the human brain will derive timely and useful information by delving into this excellent book." (David O. Staats, Doody's Review Service, June, 2009)
Comprehensively discusses the use of animal models as a tool for understanding cognition and the aging process
Provides substantive background on the newest and most widely used animal models in studies of cognition and aging
Details the normal and pathological processes of brain aging of humans in relation to animal models
Reviews the role of frontal cortical deficits and executive function in primates as related to humans as well as the use of transgenic modulation in mice to model Alzheimer's and other age-related diseases