Über den Autor
Colin J. Barnstable, D.Phil., is Professor and Chair, Department of Neural and Behavioral Sciences rnDirector, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute
Joyce Tombran-Tink, PhD, Department of Neural and Behavioral Sciences, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute
Transport in the Anterior Segmentn1. Aquaporins and water transport in the cornea nVerkman AS nn2. Roles of Corneal Epithelial Ion Transport mechanisms in mediating responses to cytokines and osmotic stressnReinach PS, Capo-Aponte JE, Mergler S, and Pokornny KS nn3. Vitamin C Transport, Delivery, and Function in the Anterior Segment of the EyenKannan R, Gukasyan HJ nnnTransporters of the Ciliary Epithelium nn4. Mechanisms of Aqueous Humor Formation: Cellular Model of aqueous inflownDo CW, Kong CW, Chan CY, Civan MM, To CHnnLens Transportersnn5. Membrane Transporters: New Roles in Lens CataractnDonaldson PJ and Lim J nn6. Lens Na+ K-ATPasenDelamere NA and Tamiya S nnTransport Across the Blood Retina Barrier n7. Pathophysiology of Perictye-Containing Retinal Microvessels: Roles of Ion Channels and TransportersnPuro DG nn8. Molecular mechanisms of the Inner Blood-Retinal Barrier Transporters nTomi M and Hosoya K nn nTransport Across the Retinal Pigment Epithelium n9. Regulation of Transport in the RPE nDibas A and Yorio T nn10. Glucose Transporters in RPE DevelopmentnRizzolo LJ nn11. Ca2+ Channels in the RPE: Modulators of RPE Function and Communication with Neighboring TissuesnStrauss O nn12. Taurine Transport Pathways in the Outer Retina in Relation to Ageing and DiseasenHussain AA and Marshall J nn13. P-glycoprotein expression and Function in the Retinal pigment epithelium nConstable PA, Lawrenson JG and Abbott NJ nnTransporters in the Retina nn14. The Retinal Rod NCKX1 and Cone/Ganglion Cell NCKX2 Na+/Ca2+-K+ ExchangersnSchnetkamp PM, Sibukawa Y, Altimimi HF, Kinjo TG, Pratikhya P,Kang KJ, and Szerencsei RT nn15. Excitatory Amino Acid Transporters in the RetinanSarthy VP and Pow D nn16. Localization and Function of GABA Transporter 1 in the retina nCasini G nn nGenetic Variants of Ocular Transporters: Implication in Drug Metabolism and Eye Diseases nn17. Biochemical Defects Associated with Genetic Mutations in the Retina Specific ABC Transporter, ABCR, and Macular Degenerative DiseasesnBiswas-Fiss EE nn18. Glutamate Transporters: Retinal Disease and RegulationnBarnett NL and Bull ND nn19. Glutamate Transport in Retinal Glial Cells During DiabetesnFletcher EL and Ward MM nn nOcular Drug Deliverynn20. The Emerging Significance of Drug Transporters and Metabolizing Enzymes to Ophthalmic Drug DesignnAttar M and Shen J nn21. Barriers in Ocular Drug DeliverynMitra AK and Gunda S nn22. Ophthalmic applications of nanotechnology nRaghava S, Goel G, Kompella UB nn23. Vitamin C Transporters in the RetinanGanapathy V, Ananth S, Smith SB, Martin PM nn24. The Plasma Membrane Transporters and Channels of Corneal EndotheliumnFischbarg J
In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.
Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides its readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.