PrefacenP. Michael Conn, PhDnconnm@ohsu.edunONPRC/OHSUnINTRODUCTORYnnnn1nnAnimal models for human diseases: an overviewnJann HaunJHAU@emed.ku.dknPanum Instituttetn2nnSelection of biomedical animal modelsnMichael S. Rand, DVM, DACLAMnmrand@email.arizona.edunUniversity of Arizonan3nnImproved models for animal researchnErnesto Bockamp, Dr.rer.nat. Leonid Eshkind, PhD Jan Hengstler, MD Rolf Sprengel, Dr. firstname.lastname@example.orgJohannes Gutenberg-Universität MainznGENERAL CONSIDERATIONSnnnn4nnThe ethical basis for animal use in researchnJames V. Parker, PhDnculligank@comcast.netnn5nnBibliographic searching tools on disease models to locate alternatives for animals in research: A website companionnLynette A. Hart Mary W. Woodnlahart@ucdavis.edunUniversity of California - Davisn6nnNIH policies on sharing of model organisms and related research resourcesnNorka Ruiz Bravo, PhD Charlene Cho, PhD JP Kim, JD, MBA, MSc, MALSnruizbran@od.nih.govnNIHn7nnDatabases for biomedical animal resourcesnRichard L. Crawford, DVM Tim Allen, MSnAWKC@val.usda.govnUDSAn8nnPsychological enrichment for animals in captivitynKristine Colemanncolemank@ohsu.edunONPRC/OHSUnWELL-ESTABLISHED MODELSnnnnnYeast, Worms, Flies, Sea Animals and Birdsnnn9nnIntegrated network modeling of molecular and genetic interactionsnGregory W Carter, PhD Vesteinn Thorsson, PhD Timothy Galitski,PhDngcarter@systemsbiology.netnInstitute for Systems Biologyn10nnThe sponge as a model of cellular recognitionnXavier Fernandez-Busquets, PhDnxfernandez_busquets@ub.edunUniversity of Barcelonan11nnSea urchin embryo - a model system for analyzing a variety of cellular activities during early developmentnTetsuya Kominami Hiromi Takatantkom@sci.ehime-u.ac.jpnEhime Universityn12nnC. elegans models of human neurodegenerative deseases: a powerful tool to identify molecular mechanisms and novel therapeutic targetsnRichard Nass, PhD Lihsia Chennrichard.email@example.comVanderbilt University Medical Centern13nnZebrafish as a model for developmentnBrian A Link, PhD Sean G. Megason, PhDnblink@mail.mcw.edunMedical College of Wisconsinn14nnZebrafish as a model for studying adult effects of challenges to the embryonic nervous systemnElwood A. Linney, PhD Nicole Marie Roy, PhDnelwood.firstname.lastname@example.orgDuke University Medical Centern15nnModeling cognitive and neurodegenerative disorders in Drosophila melanogasternMinoru Saitoe Junjiro Horiuchinsaitoe@tmin.ac.jpnTokyo Metropolitan Institute for Neuroscience (TMIN)n16nnBiomedical research with honey beesnMichelle M. Elekonich, PhDnmichelle.email@example.comUniversity of Nevada Las Vegasn17nnEstablishing and maintaining a Xenopus laevis colony for research laboratoriesnMichael Levin, PhD Punita Koustubhan Debra Sorocconmlevin@forsyth.orgnThe Forsyth Center for Regenerative and Developmental Biology and Harvard School of Dental Medicinen18nnThe chicken as a model organismnJanice M. Bahr,
The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.
Unique reflection of the diversity and utility of models used in biomedicine
Novel discussion of reproductive, mitotic, developmental or aging cycles in a range of organisms in comparison with humans
Insights on how some organisms that are able to grow in laboratory settings or lend themselves to convenient analyses have defined genomes or present especially good human models of human or animal disease
Uses a range of tables and figures to make comparisons of models so that observations not available in primary publications can become useful to the reader