I. Cannabinoid Receptor Ligands and Structure Activity Relationships nChapter 1. Structure Activity Relationships (SAR) of Classical CannabinoidsnRaj K. RazdannnChapter 2. Endocannabinoids and Their Synthetic AnalogsnV. Kiran Vemuri and Alexandros MakriyannisnnChapter 3. Cannabimimetic Indoles, Pyrroles and Indenes: Structure-Activity Relationships and Receptor Interactions nJohn W. HuffmannnChapter 4. Structure-Activity Relationships and Conformational Freedom of CB1 Receptor Antagonists and Inverse AgonistsnYanan Zhang, Herbert H. Seltzman, Marcus Brackeen and Brian F. Thomasnn nII. Cannabinoid Receptor Biology nnChapter 5. Cannabinoid Receptor Genetics and EvolutionnMaurice R. Elphick and Michaela Egertovánn nIII. Cannabinoid Receptor Molecular PharmacologynnChapter 6. Cannabinoid Receptor Signal Transduction PathwaysnEmma Scotter, Scott Graham and Michelle GlassnnChapter 7. Cannabinoid Agonist and Inverse Agonist Regulation of G-Protein CouplingnAllyn C. Howlett, Lea W. Padgett and Joong-Youn ShimnnChapter 8. Molecular Biology of Cannabinoid Receptors: Mutational Analyses of the CB receptorsnMary E. AboodnnChapter 9. Models of Cannabinoid Inverse Agonism, Neutral Antagonism and Agonism: Tools for RationalDrug DesignnDow P. Hurst and Patricia H. Reggionn nIV. The Endocannabinoid SystemnnChapter 10. Endocannabinoids as Modulators of Synaptic SignalingnSachin Patel and Cecilia J. HillardnChapter 11. New Insights into the Endocannabinoid System by using Cannabinoid Receptor Knockout MicenMeliha Karsak, Itai Bab and Andreas Zimmernn nV. Cannabinoid Receptor PharmacologynnChapter 12. Preclinical Pharmacological and Brain Bioassay Systems for CB1 Cannabinoid ReceptorsnJenny L. Wiley and Billy R. MartinnnChapter 13. Therapeutic Applications for Agents that Act at CB1 and CB2 ReceptorsnRoger G. Pertwee and Adèle Thomas
As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors (TM) series, this volume highlights its receptor with the most thorough, focused and essential information available.
Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.
Offers a comprehensive look at cannabinoid structure activity relationships for all structural classes of cannabinoid agonists, including endogenous cannabinoids as well as cannabinoid antagonists/inverse agonists
Provides a thorough overview of the cannabinoid receptor field including the genetics and evolution of the cannabinoid system, as well as the molecular biology and structure/function of the cannabinoid receptors
Discusses the many therapeutic opportunities provided by the endocannabinoid system, including treatments for metabolic syndrome and immune system disorders