Part I. Methodologyn n Basic Principles of Epidemiology and Biostatisticsn n Diagnosisn n Treatmentn n Prognosisn n Part II. Spinal Cord, Anterior Horn Cell, and Nerve Rootsn n Amyotrophic Lateral Sclerosisn n Cervical Spondylosisn n Lumbar Spondylosisn n Part III. Peripheral Nerve Diseasen n Polyneuropathyn n Paraproteinemic Neuropathiesn n Vasculitic Neuropathyn n Guillain-Barré Syndromen n Chronic Inflammatory Demyelinatingn n Polyradiculoneuropathyn n Multifocal Motor Neuropathyn n Inherited Neuropathiesn n Carpal Tunnel Syndromen n Ulnar Neuropathy at the Elbown n Part IV. Neuromuscular Junction Disordersn n Myasthenia Gravisn n Lambert-Eaton Myasthenic Syndromen n Part V. Muscle Diseasen n Inflammatory Myopathyn n Idiopathic Hyper-CK-emian n Statin-Induced Myopathyn n Metabolic Myopathyn n Critical Illness Weakness, Myotonic Dystrophyn n Facioscapulohumeral Muscular Dystrophyn n Index
This volume presents a critical appraisal of the neurological literature on neuromuscular disease from an evidence-based perspective. Writing in a readable, accessible style, the author considers, in detail, a broad range of the published literature relevant not only to questions of treatment, but also to issues of diagnosis and prognosis. Through a series of questions and answers concerning specific neuromuscular disorders, each chapter critiques the best available evidence to illustrate strengths and weaknesses of the data and make the reader aware of the quality of clinical research studies in general. Introductory chapters facilitate this learning process by elucidating the epidemiological and biostatistical issues pertinent to diagnosis, treatment, and prognosis. A broad range of disorders of the anterior horn cell, nerve roots, peripheral nerves, neuromuscular junction, and muscle are critically appraised and discussed.