Part I: Basic Pathophysiology and Biochemistry of Diabetic Nephropathyn n A. Pathophysiologyn n Angiotensin II and Its Receptors in the Pathogenesis of Diabetic Nephropathyn David J. Leehey, Ashok K. Singh, and Rekha Singhn n Altered Renal Microvascular Function in Early Diabetesn Pamela K. Carmines, Joseph P. Bast, and Naohito Ishiin n B. Interstitial Diseasen n Proteinuria and Interstitial Fibrogenesis in Diabetic Nephropathyn Raimund Hirschbergn n C. Podocytesn n Podocytes and Diabetic Nephropathyn George Jerums, Sianna Panagiotopoulos, and Richard MacIsaacn n D. Altered Metabolic Pathwaysn n Altered Glucose Transport and Its Metabolic Effects in Glomerular Cellsn Charles W. Heilign n mRNA Translation in Diabetic Nephropathyn Balakuntalam S. Kasinath, Myung Ja Lee, Denis Feliers, and Nahum Sonenbergn n The Hexosamine Biosynthesis Pathway: Contribution to the Pathogenesis of Diabetic Nephropathyn I. George Fantus, Howard J. Goldberg, Catharine I. Whiteside, and Delilah Topicn n E. Nonenzymatic Glycosylationn n Glycation: Receptor for Advanced Glycation Endproducts and Diabetic Nephropathyn Vivette D'Agati and Ann Marie Schmidtn n F. Oxidative Stressn n Oxidative and Glycooxidative Stress in Diabetic Nephropathyn Frederick R. DeRubertis and Patricia A. Cravenn n G. Growth Factorsn n Connective Tissue Growth Factor in the Pathogenesis of Diabetic Nephropathy: A Target for Therapeutic Interventionn Bruce L. Riser, Alessia Fornoni, and Sujatha Karoorn n Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathyn Geoffrey Boner and Mark E. Coopern n Transforming Growth Factor-b Signal Transduction in the Pathogenesis of Diabetic Nephropathy: Identifying Molecular Targets for Therapeutic Interventionn Sheldon Chen and Fuad N. Ziyadehn n H. New Approaches to the Study of Diabetic Nephropathyn n Hepatocyte Growth Factor: Physiological and Therapeutic Ligand to Attenuate Diabetic Nephropathyn Shinya Mizuno and Toshikazu Nakamuran n Proteomics in the Investigation of Diabetic Nephropathyn Visith Thongboonkerdn n Gene Expression Profiling in the Investigation of Diabetic Nephropathyn Katalin Susztak, Erwin Bottinger, and Kumar Sharman n PPAR-g Ligands and Diabetic Nephropathyn Keiji Isshiki, Daisuke Koya, and Masakazu Hanedan n a-Endosulfine in Diabetic Nephropathyn Jerry Yee and Balazs Szamosfalvin n The Prospect of a Novel Therapeutic, Bone Morphogenetic Protein-7, in Diabetic Nephropathyn Keith A. Hruska, Laura DePetris, Tingting Li, Song Wang, Theresa Geurs, Frank Strebeck, Qing Chen, and Helen Liapisn n Part II: Clinical Aspects of Diabetic Nephropathyn n A. Genetics and Risksn n Genetic Determinants of Diabetic Nephropathy in Type 2 Diabetesn Grzegorz Placha and Andrzej S. Krolewskin n Major Risk Indicators for Diabetic Kidney Diseasen Katherine R. Tuttlen n B. Histopathology and Special Populationsn n The Structure of Human Diabetic Nephropathyn Michael Mauer and Behzad Najafiann n Diabetic Kidney Disease in Transitional and Disadvantaged Populationsn E. Jennifer Weil and Robert G. Nelsonn n C. Diagnosis and Treatmentn n Screening and Treatment of Early Diabetic Renal Disease in Type 1 and Type 2 Diabetesn Ellie Chuang and Mark E. Molitchn n Treatment in Advanced Renal Disease in Type 1 and Type 2 Diabetesn Eberhard Ritz and Gunter Wolfn n Diabetic and Renal Disease: ACE Inhibitors and/or Angiotensin Receptor Blockers: Does It Matter?n Carl Erik Mogensen and Niels Holmark Andersenn n Management of Diabetic End-Stage Renal Disease With Dialysisn Ploumis S. Passadakis and Dimitrios G. Oreopoulosn n D. Rela
A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.