Now in its second edition Modern Hematology reflects the major advances in the understanding, diagnosis, and treatment of blood disorders. Each chapter is illustrated by tables, figures, and a selection of color plates.
Over the past few decades the powerful methods of statistical physics and Euclidean quantum field theory have moved closer together, with common tools based on the use of path integrals. The interpretation of Euclidean field theories as particular systems of statistical physics has opened up new avenues for understanding strongly coupled quantum systems or quantum field theories at zero or finite temperatures.
Accordingly, the first chapters of this book contain a self-contained introduction to path integrals in Euclidean quantum mechanics and statistical mechanics. The resulting high-dimensional integrals can be estimated with the help of Monte Carlo simulations based on Markov processes. The most commonly used algorithms are presented in detail so as to prepare the reader for the use of high-performance computers as an experimental tool for this burgeoning field of theoretical physics.
Several chapters are then devoted to an introduction to simple lattice field theories and a variety of spin systems with discrete and continuous spins, where the ubiquitous Ising model serves as an ideal guide for introducing the fascinating area of phase transitions. As an alternative to the lattice formulation of quantum field theories, variants of the flexible renormalization group methods are discussed in detail. Since, according to our present-day knowledge, all fundamental interactions in nature are described by gauge theories, the remaining chapters of the book deal with gauge theories without and with matter.
This text is based on course-tested notes for graduate students and, as such, its style is essentially pedagogical, requiring only some basics of mathematics, statistical physics, and quantum field theory. Yet it also contains some more sophisticated concepts which may be useful to active researchers in the field. Each chapter ends with a number of problems guiding the reader to a deeper understanding of some of the material presented in the main text and, in most cases, also features some listings of short, useful computer programs.
Contents
Foreword
Preface1. Basic Biology of Hemopoiesis
Reinhold Munker
2. Molecular Biology and Cytokines
Reinhold Munker and Amanda Sun
3. Supportive Care in Hematology
John Hiemenz and Reinhold Munker
4. Transplantation of Stem Cells from Bone Marrow, Blood and the Umbilical Cord
Ronald Paquette and Reinhold Munker
5. Anemias: General Considerations, Microcytic, and Megaloblastic Anemias
Reinhold Munker
6. Hemolytic Anemias
Reinhold Munker, Ali Mansouri, Snehalata C. Gupte, and Vishwas Sakhalkar
7. Leukocytosis, Leukopenia, and Other Changes of the Myeloid Series
Reinhold Munker
8. The Myeloproliferative Syndromes
Ronald Paquette, Erhard Hiller, and Reinhold Munker
9. Acute Myelogenous Leukemias
Reinhold Munker
10. Acute Lymphoblastic Leukemias
Reinhold Munker and Vishwas Sakhalkar
11. Myelodysplastic Syndromes
Ronald Paquette and Reinhold Munker
12. Aplastic Anemias
Ronald Paquette and Reinhold Munker
13. Lymphocytosis, Lymphopenia, Lymphadenopathy, and Splenomegaly
Reinhold Munker
14. Hodgkin's Lymphoma
Erhard Hiller and Reinhold Munker
15. The Non-Hodgkin Lymphomas
Reinhold Munker, Jay Marion, Gang Ye, and Martin H. Dreyling
16. Multiple Myeloma and Related Paraproteinemias
Jonathan Glass and Reinhold Munker
17. Congenital and Acquired Immunodeficiencies
Vishwas Sakhalkar and Reinhold Munker
18. Infections Relevant to Hematology
Reinhold Munker
19. Basic Principles of Hemostasis
Erhard Hiller
20. Bleeding Disorders
Erhard Hiller
21. Thrombophilia, Thromboembolic Disease, and Antithrombotic Therapy Erhard Hiller
22. Transfusion Medicine and Immunohematology
Grace Tenorio, Snehalata C. Gupte, and Reinhold Munker
23. Storage Disorders in Hematology
Reinhold Munker
Appendices
1) Glossary of Cytostatic Drugs and Targeted Therapies p
2) CD Nomenclature for Human Leukocyte Antigens p
3) Normal Laboratory Values p
4) Program Requirements for Fellowship Education in Hematology p
5) Databases in Hematology p
From the reviews of the second edition:
"This book works as a stand-alone text for its intended purpose of providing a practical approach for diagnosis and management. ... Modern Hematology ... is well-designed to accompany structured lectures, practical laboratories, and demonstrations for hematology courses for medical students, medical technologists, and others in related fields. This textbook does the job well. It also is well suited to serve as a basic reference and a means of identifying where to obtain more comprehensive or specialized information." (James R. Egner, Journal of the American Medical Association, December, 2007)
1
Inhaltsverzeichnis
Contents
Foreword
Preface
1. Basic Biology of Hemopoiesis
Reinhold Munker
2. Molecular Biology and Cytokines
Reinhold Munker and Amanda Sun
3. Supportive Care in Hematology
John Hiemenz and Reinhold Munker
4. Transplantation of Stem Cells from Bone Marrow, Blood and the Umbilical Cord
Ronald Paquette and Reinhold Munker
5. Anemias: General Considerations, Microcytic, and Megaloblastic Anemias
Reinhold Munker
6. Hemolytic Anemias
Reinhold Munker, Ali Mansouri, Snehalata C. Gupte, and Vishwas Sakhalkar
7. Leukocytosis, Leukopenia, and Other Changes of the Myeloid Series
Reinhold Munker
8. The Myeloproliferative Syndromes
Ronald Paquette, Erhard Hiller, and Reinhold Munker
9. Acute Myelogenous Leukemias
Reinhold Munker
10. Acute Lymphoblastic Leukemias
Reinhold Munker and Vishwas Sakhalkar
11. Myelodysplastic Syndromes
Ronald Paquette and Reinhold Munker
12. Aplastic Anemias
Ronald Paquette and Reinhold Munker
13. Lymphocytosis, Lymphopenia, Lymphadenopathy, and Splenomegaly
Reinhold Munker
14. Hodgkin's Lymphoma
Erhard Hiller and Reinhold Munker
15. The Non-Hodgkin Lymphomas
Reinhold Munker, Jay Marion, Gang Ye, and Martin H. Dreyling
16. Multiple Myeloma and Related Paraproteinemias
Jonathan Glass and Reinhold Munker
17. Congenital and Acquired Immunodeficiencies
Vishwas Sakhalkar and Reinhold Munker
18. Infections Relevant to Hematology
Reinhold Munker
19. Basic Principles of Hemostasis
Erhard Hiller
20. Bleeding Disorders
Erhard Hiller
21. Thrombophilia, Thromboembolic Disease, and Antithrombotic Therapy Erhard Hiller
22. Transfusion Medicine and Immunohematology
Grace Tenorio, Snehalata C. Gupte, and Reinhold Munker
23. Storage Disorders in Hematology
Reinhold Munker
Appendices
1) Glossary of Cytostatic Drugs and Targeted Therapies p
2) CD Nomenclature for Human Leukocyte Antigens p
3) Normal Laboratory Values p
4) Program Requirements for Fellowship Education in Hematology p
5) Databases in Hematology p
Klappentext
Now in its second edition, Modern Hematology: Biology and Clinical Management reflects the major advances in the understanding, diagnosis, and treatment of blood disorders. It describes the latest clinical and scientific developments as well as details targeted and molecular therapies. The book brings together facts, concepts, and protocols important for the practice of hematology. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest. As in the previous edition, each chapter is illustrated by tables, figures, and a selection of color plates.
Updated and expanded to reflect major advances in the understanding, diagnosis, and treatment of blood disorders
