Classification of High-Grade GliomannnnHistologic Classifications nnRichard PraysonnnnnMolecular ClassificationsnnGreg FullernnnnClinical CharacteristicsnnnnPediatric High-Grade GliomannBruce CohennnnnAdult High-Grade GliomannSusan Chang and Nicholas ButowskinnnnDiagnostic Tools for High-Grade GliomannnnComputerized TomographynnThomas Masaryk and Manzoor AhmednnnnMagnetic Resonance ImagingnnPaul RuggierinnnnMagnetic Resonance SpectroscopynnMitchell Berger, G. Evren Keles, and Soonmee ShannnnBiological ImagingnnTim Roberts and Andrea KassnernnnnNuclear ImagingnnAlexander M Spence, David Mankoff, Mark Muzc, and Kristin Swanson nnnnMagneto-EncephalographynnMichael Steinmetz, Jurgen Luders, and Edward BenzelnnnnManagementnnnnGeneral ConsiderationsnnGlen StevensnnnnSurgical TechniquesnnGene BarnettnnnnRadiation TherapynnMinesh Mehta and Hiral ShahnnnnBrachytherapynnMichael McDermott, Marcus Ware, and P.K. SneednnnnRadiosurgerynnJohn Suh and Gene Barnett nnnnChemotherapiesnnDavid Peereboom and Manmeet Singh AhluwaliannnnNursing ConsiderationsnnKathy Lupica and Gail DitznnnnContemporary Investigational TreatmentsnnnnConvection Enhanced DeliverynnAndrew KannernnnnImmunotoxinsnnSyed Husain and Raj Puri nnnnSmall Molecule AgentsnnMichael Vogelbaum and Tina ThomasnnnnImmunotherapynnRoberta Glick, Terry Lichter, Henry Lin, and Edward CohennnnnMonoclonal AntibodiesnnAbraham Boskovitz David Reardon, Carol Wikstrand, Michael Zalutsky, and Darell BignernnnnOncolytic Viral TherapiesnnAntonio Chiocca and M.L. LamfersnnnnBiologic ModifiersnnAleck Hercbergs, Alex Mason, and Steve TomsnnnnGene TherapynnAlessandro Olivi and Maciej LesniaknnnnBoron Neutron Capture Therapy of Brain Tumors: Current Status and Future ProspectsnnRolf Barth, Jeffrey Coderre, Graca Vicente, Thomas Blue, and Shin-Ichi MiyatakennnnPhotodynamic TherapynnAndrew Kaye and Bhadrakant Kavar
This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such "breakthrough" in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).