I. Class I Histone Deacetylasesn n Histone Deacetylase 1n Dominique Meunier and Christian Seisern n Biochemistry of Multiprotein HDAC Complexesn Alejandro Vaquero, Michael Scher, and Danny Reinbergn n The Biology of HDAC3n Edward Seton n The Biology of HDAC8, a Unique Class I Histone Deacetylasen David Waltregny and Vincent Castronovon n II. Class II Histone Deacetylasesn n Regulation of Muscle Gene Expression by Histone Deacetylasesn Timothy A. McKinsey and Eric N. Olsonn n The Class IIa Histone Deacetylases: Functions and Regulationn Herbert G. Kasler and Eric Verdinn n Histone Deacetylases in the Response to Misfolded Proteinsn J. Andrew McKee and Tso-Pang Yaon n III. Class III Histone Deacetylasesn n Comparison of Sirtuin Sequences Between Archaea and Vertebratesn Roy A. Fryen n Structure of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylasesn Kehao Zhao and Ronen Marmorsteinn n The Enzymology of SIR2 Proteinsn Margie T. Borra and John M. Denun n The Class III Protein Deacetylases: Homologs of Yeast Sir2pn Bjoern Schwer, Brian J. North, Nidhi Ahuja, Brett Marshall, and Eric Verdinn n IV. Histone Deacetylase Inhibitorsn n HDAC Inhibitors: Discovery, Development, and Clinical Impactsn Akihiro Ito, Norikazu Nishino, and Minoru Yoshidan n Cell Cycle Targets of Histone Deacetylase Inhibitorsn Brian Gabriellin n HDAC Inhibitors: An Emerging Anticancer Therapeutic Strategyn Paul Kwon, Meier Hsu, Dalia Cohen, and Peter Atadjan n Index
A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.