Part I: Basic Stem Cell Biologyn n Embryonic Stem Cells: Derivation, Properties, and Therapeutic Implicationsn Victoria L. Browning and Jon S. Odoricon n Germ Line Stem Cellsn Makoto C. Naganon n Umbilical Cord Stem Cellsn Kathy E. Mitchelln n Differentiation Potential of Adult Stem Cellsn Henry E. Young and Asa C. Black, Jr.n n Growth Conditions for Primate vs Murine Embryonic Stem Cellsn Gillian M. Beattie, Nathan Bucay, Rohan Humphrey, Ana D. Lopez, and Alberto Hayekn n Part II: Translational Researchn n Islet Precursor Cells in Adult Pancreatic Isletsn Gladys Teitelman and Irem Nasirn n Transcription Factor-Directed Differentiation of Stem Cells Along an Endocrine Lineagen William L. Lowe, Jr.n n Generation of Islet-Like Structures From ES Cellsn Nadya Lumelskyn n The Therapeutic Potential of Liver Repopulation for Metabolic or Endocrine Disordersn Sanjeev Guptan n The Manipulation of Mesenchymal Stem Cells for Bone Repairn Shelley R. Winnn n Spermatogenesis From Transplanted Spermatogenic Stem Cellsn Michael D. Griswold and Derek McLeann n Hematopoietic Stem Cell Transplant in the Treatment of Autoimmune Endocrine Diseasen Jody Schumacher and Ewa Carriern n Preclinical Trials for Stem Cell Therapyn Linda B. Lester, K. Y. Francis Pau, and Don P. Wolfn n Index
A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders.
A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders.