Part I. Fundamental Conceptsn n Overviewn Sadmeet Singh and Gurmit Singhn n Parathyroid Hormone-Related Peptide and Malignancyn David Goltzmann n Vitamin D and Vitamin D Analogs in Cancer Progression and Metastasisn Richard Kremer and Shafaat A. Rabbanin n Role of TGF-b and IGF in Tumor Progression and Bone Metastasesn Erin Giles and Gurmit Singhn n Biologic and Therapeutic Implications of Osteomimicry and Epithelial-Mesenchymal Transition in Prostate Cancern Wen-Chin Huang, Valerie Odero-Marah, and Leland W. K. Chungn n Roles of Immune-Cell-Derived Matrix Metalloproteinases in Tumor Growth and Metastasisn Kristina A. Szabo and Gurmit Singhn n Contribution of Osteopontin to the Development of Bone Metastasisn Alison L. Allan, Alan B. Tuck, Vivien H. C. Bramwell, Theodore A. Vandenberg, Eric W. Winquist, and Ann F. Chambersn n Role of Interleukin-11 in Osteolytic Bone Metastasisn Ryan R. Simon, Martin K. Butcher, and Stephen G. Shaughnessyn n Cell Adhesion Molecules in Tumor Metastasisn Sujata Persad and Gurmit Singhn n PTHrP and Cancer: Prostate and Lungn Leonard J. Deftos, D. W. Burton, and Randolph H. Hastingsn n Antithrombotics in Tumor Growth and Metastasisn Shaker A. Mousan n Part II. Therapeutic Strategiesn n Challenges and Strategies in the Analysis of Multiple Events in Oncologyn Pierre P. Major and Richard J. Cookn n Integrins: Novel Targets for the Treatment of Bone Metastasisn Graham C. Parry, Fernando Doñate, Marian L. Plunkett, David E. Shaw, Steven Pirie-Shepherd, and Andrew P. Mazarn n Bone Metastasis and Pathological Fractures: Bone Tissue Engineering as a Novel Therapyn Laurie A. McDuffee, Nigel Colterjohn, and Gurmit Singhn n Role of Photodynamic Therapy for Bone Metastasisn Shane Burch and Albert J. M. Yeen n Docetaxel for Metastatic Cancer and Its Rolein Combination Therapies for Advanced Prostate Cancern Ellen K. Wasan, Martin Gleave, Karen Fang, Kim Chi, Gwyn Bebb, Lincoln Edwards, and Marcel B. Ballyn n Use of Tetracyclines for Bone Metastasesn Eric Seidlitz, Zeina Saikali, and Gurmit Singhn n Role of Bisphosphonates in Skeletal Metastasesn Arif Hussain and Fred Saadn n Radiation Treatment of Bone Metastasesn Edward Chow, Jackson Wu, and Elizabeth Toni Barnesn n Index
A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.