Part I. Genes and Polymorphisms in Cardiovascular Diseasen n Angiotensin II Receptor Polymorphisms and Hypertensionn Bruno Baudinn n Angiotensinogen Gene Polymorphisms and Hypertensionn Ashok Kumarn n Substitution Mapping: Using Congenic Strains to Detect Genes Controlling Blood Pressuren Bina Joe and Michael R. Garrettn n Local Production of Angiotensinogen: Insights From Genetic Manipulation of Micen Kamal Rahmouni and Curt D. Sigmundn n Cardiovascular Pharmacogenomicsn Julie A. Johnson and Larisa H. Cavallarin n Genetic Polymorphisms and Response to HMG-CoA Reductase Inhibitorsn Anke-Hilse Maitland-van der Zee, Olaf H. Klungel, and Anthonius de Boern n Monogenic Causes of Heart Failure: Familial Dilated Cardiomyopathyn Hideko Kasaharan n Part II. Gene Transfer for Combating Cardiovascular Diseasen n Gene Therapy vs Pharmacotherapyn Ryuichi Morishitan n Molecular Therapeutic Approaches for Myocardial Protectionn Alok S. Pachori, Luis G. Melo, and Victor J. Dzaun n Gene Transfer and the Cardiovascular Systemn William H. Miller, Stuart A. Nicklin, Andrew H. Baker, and Anna F. Dominiczakn n Kallikrein Gene Transfer in Hypertension, Cardiovascular and Renal Disease, and Stroken Julie Chao and Lee Chaon n Current and Future Novel Targets of Gene Therapy for Hypertensionn Michael J. Katovich, Justin L. Grobe, and Mohan K. Raizadan n Application of Viral Gene Transfer in Studies of Neurogenic Hypertensionn Sergey Kasparov, A. G. Teschemacher, and Julian F. R. Patonn n Vigilant Vectors: Intelligent Gene Vectors for Cardioprotection in Myocardial Ischemian M. Ian Phillips and Yi Tangn n Gene Therapy for Cerebral Arterial Diseasesn Yoshimasa Watanabe and Donald D. Heistadn n Part III. Regenerative Tissues for the Diseased Cardiovascular Systemn n Therapeutic Angiogenesis and Vasculogenesis for Tissue Regenerationn Paolo Madeddun n Cell Transplantation: The New Frontiern Shafie Fazel, Paul W. M. Fedak, Richard D. Weisel, Denis Angoulvant, Terrence M. Yau, and Ren-Ke Lin n Embryonic Stem Cells and the Cardiovascular Systemn Neta Lavon and Nissim Benvenistyn n Index
Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.