I. IntroductionnnnnIntroduction to Magnetic Resonance Imaging and SpectroscopynnPippa StoreynnnnMagnetic Resonance Microscopy: Concepts, Challenges, and State-of-the-ArtnnBarjor GiminnnnII. AnatomynnnnMagnetic Resonance Imaging of Embryonic and Fetal Development in Model SystemsnnEric T. Ahrens, Mangala Srinivas, Saverio Capuano, Hyagriv N. Simhan, and Gerald P. SchattennnnnMouse Morphological Phenotyping With Magnetic Resonance ImagingnnX. Josette ChennnnnMagnetic Resonance Microscopy of Mouse Brain DevelopmentnnSusumu Mori, Jiangyang Zhang, and Jeff W. M. BultennnnIII. PhysiologynnnnQuantitative Perfusion Imaging Using Arterial Spin LabelingnnDonald S. WilliamsnnnnPhysiology of Functional Magnetic Resonance Imaging: Energetics and FunctionnnIkuhiro Kida and Fahmeed HydernnnnFunctional Magnetic Resonance Imaging of the KidneynnPottumarthi V. PrasadnnnnCardiac Magnetic Resonance Spectroscopy: A Window for Studying PhysiologynnMichael HornnnnnIV. PathophysiologynnnnApplication of Magnetic Resonance Imaging to Study Pathophysiology in Brain Disease ModelsnnRick M. DijkhuizennnnnMagnetic Resonance Imaging of Tumor PhysiologynnArvind P. PathaknnnnMagnetic Resonance Imaging in Preclinical Drug DevelopmentnnMatthew D. Silva and Sudeep ChandrannnnV. Novel Contrast Agents and MechanismsnnnnHyperpolarized Gas and Oxygen-Enhanced Magnetic Resonance Imaging nnVu M. MainnnnTissue pH Measurement by Magnetic Resonance Spectroscopy and Imaging nnNatarajan RaghunandnnnnBiological Applications of Manganese-Enhanced Magnetic Resonance ImagingnnRobia G. PautlernnnnTargeted Magnetic Resonance Imaging Contrast AgentsnnShelton D. Caruthers, Patrick M. Winter, Samuel A. Wickline, and Gregory M. LanzannnnDesign and Characterization of Magnetic Resonance Imaging Gene Reporters nnAngelique LouiennnnIntracellular Endosomal Magnetic Labeling of CellsnnJeff W. M. BultennnnIndex
Leading experts in the use of MRI explain its basic principles and demonstrate its power to understand biological processes with numerous cutting-edge applications. To illustrate its capability to reveal exquisite anatomical detail, the authors discuss MRI applications to developmental biology, mouse phenotyping, and fiber architecture. MRI can also provide information about organ and tissue function based on endogenous cantrast mechanisms. Examples of brain, kidney, and cardiac function are included, as well as applications to neuro and tumor pathophysiology. In addition, the volume demonstrates the use of exogenous contrast material in functional assessment of the lung, noninvasive evaluation of tissue pH, the imaging of metabolic activity or gene expression that occur on a molecular level, and cellular labeling using superparamagnetic iron oxide contrast agents.