Prologue: Nano- and Microimaging Surgical Anesthesia in Epilepsy Patientsn n I. Parkinson's Diseasen n Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Parkinson's Disease: Structural vs Functional Changesn W. R. Wayne Martinn n Positron Emission Tomography and Single-Photon Emission Tomography in the Diagnosis of Parkinson's Disease: Differential Diagnosis From Parkinson-Like Degenerative Diseasesn Paul D. Actonn n Positron Emission Tomography in Parkinson's Disease: Cerebral Activation Studies and Neurochemical and Receptor Researchn André R. Troiano and A. Jon Stoessln n [123I]-Altropane SPECT: How It Compares to Other Positron Emission Tomography and Single-Photon Emission Tomography Dopamine Transporters in Early Parkinson's Diseasen Hubert H. Fernandez, Paula D. Ravin, and Dylan P. Wintn n Positron Emission Tomography and Embryonic Dopamine Cell Transplantation in Parkinson's Diseasen Yilong Ma, Vijay Dhawan, Curt Freed, Stanley Fahn, and David Eidelbergn n II. Alzheimer's Diseasen n Neurotoxicity of the Alzheimer's b-Amyloid Peptide: Spectroscopic and Microscopic Studiesn David R. Howlettn n Functional Imaging and Psychopathological Consequences of Inflammation in Alzheimer's Dementian Jan Versijpt, Rudi A. Dierckx, and Jakob Korfn n Neurotoxic Oxidative Metabolite of Serotonin: Possible Role in Alzheimer's Diseasen Ladislav Volicer, Monika Z. Wrona, W. R. Wayne Matson, and Glenn Dryhurstn n Predicting Progression of Alzheimer's Disease With Magnetic Resonancen Kejal Kantarci and Clifford R. Jack, Jr.n n Stages of Brain Functional Failure in Alzheimer's Disease: In Vivo Positron Emission Tomography and Postmortem Studies Suggest Potential Initial Reversibility and Later Irreversibilityn Stanley I. Rapoportn n III. Epilepsyn n Neocortical Epilepsy: a-Methyl-l-Tryptophan and Positron EmissionTomography Studiesn Jun Natsume, Andrea Bernasconi, and Mirko Diksicn n Pediatric Cortical Dysplasia: Positron Emission Tomography Studiesn Bharathi Dasan Jagadeesan, Csaba Juhász, Diane C. Chugani, and Harry T. Chuganin n Bioimaging l-Tryptophan in Human Hippocampus and Neocortex: Subtyping Temporal Lobe Epilepsyn Steven V. Pacia and Patricia A. Broderickn n In Vivo Intrinsic Optical Signal Imaging of Neocortical Epilepsyn Sonya Bahar, Minah Suh, Ashesh Mehta, and Theodore H. Schwartzn n Intraoperative Magnetic Resonance Imaging in the Surgical Treatment of Epilepsyn Theodore H. Schwartzn n Periodic Epileptiform Discharges Associated With Increased Cerebral Blood Flow: Role of Single-Photon Emission Tomography Imagingn Imran I. Ali and Noor A. Pirzadan n Imaging White Matter Signals in Epilepsy Patients: A Unique Sensor Technologyn Patricia A. Broderick and Steven V. Pacian n IV. Leukodystrophy (White Matter) Diseasesn n Overview of the Leukoencephalopathies: An MRI Point of Viewn Edwin H. Kolodnyn n Pyramidal Tract Involvement in Adult Krabbe's Disease: Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy Abnormalitiesn Laura Farina, Alberto Bizzi, and Mario Savoiardon n Imaging Leukodystrophies: Focus on Lysosomal, Peroxisomal, and Non-Organelle Pathologyn Annette O. Nusbaumn n Advanced Magnetic Resonance Imaging in Leukodystrophiesn Edwin Y. Wang and Meng Lawn n Childhood Mitochondrial Disorders and Other Inborn Errors of Metabolism Presenting With White Matter Diseasen Adeline Vanderver and Andrea L. Gropmann n Mitochondrial Disease: Brain Oxidative Metabolism Studied by 31P, 1H, and 13C Magnetic Resonance Spectroscopy, Functional Magnetic Resonance Imaging, and Positron Emission Tomographyn Graham J. Kempn n Index
Bioimaging is in the forefront of medicine for the diagnosis and helps to predict the progression of AD via mild cognitive treatment of neurodegenerative disease. Conventional magnetic impairment (MCI) studies. resonance imaging (MRI) uses interactive external magnetic fields Novel neuroimaging technologies, such as neuromolecular and resonant frequencies of protons from water molecules. imaging (NMI) with a series of newly developed BRODERICK ® However, newer sequences, such as magnetization-prepared rapid PROBE sensors, directly image neurotransmitters, precursors, acquisition gradient echo (MPRAGE), are able to seek higher and metabolites in vivo, in real time and within seconds, at separate levels of anatomic resolution by allowing more rapid temporal and selective waveform potentials. NMI, which uses an imaging. Magnetic resonance spectroscopy (MRS) images electrochemical basis for detection, enables the differentiation of metabolic changes, enabling underlying pathophysiologic neurodegenerative diseases in patients who present with mesial dysfunction in neurodegeneration to be deciphered. Neuro- versus neocortical temporal lobe epilepsy. In fact, NMI has some 1 chemicals visible with proton H MRS include N-acetyl aspartate remarkable similarities to MRI insofar as there is technological (NAA), creatine/phosphocreatine (Cr), and choline (Cho); NAA dependence on electron and proton transfer, respectively, and is considered to act as an in vivo marker for neuronal loss and/or further dependence is seen in both NMI and MRI on tissue neuronal dysfunction. By extending imaging to the study of composition such as lipids.