1. Microfabrication Techniques for Biologists: A Primer on Building Micromachines Douglas Chinn 2. The Application of Microfluidics in Biology David Holmes and Shady Gawad 3. Rapid Prototyping of Microstructures by Soft Lithography for Biotechnology Daniel B. Wolfe, Dong Qin, and George M. Whitesides 4. Chemical Synthesis in Micro Reactors Paul Watts and Stephen J. Haswell 5. The Electroosmotic Flow (EOF) Gary W. Slater, Frédéric Tessier, and Katerina Kopecka 6. Microengineered Neural Probes for in vivo Recording Karla D. Bustamante Valles 7. Impedance Spectroscopy and Optical Analysis of Single Biological Cells and Organisms in Microsystems Shady Gawad, David Holmes, Giuseppe Benazzi, Philippe Renaud, and Hywel Morgan 8. Dielectrophoresis as a Cell Characterization Tool Kai F. Hoettges 9. AC-Electrokinetic Applications in a Biological Setting Fatima H. Labeed 10. Wireless Endoscopy: Technology and Design David R. S. Cumming, Paul A. Hammond, and Lei Wang
Microelectronic engineering has revolutionized electronics, providing new, faster and cheaper ways of doing things - and now the same technology is being applied to biotechnology and molecular biology. As sample volume is reduced, reaction speed and detector sensitivity are increased whilst sample and reagent requirements and device cost are reduced. Microelectronic engineering provides the potential for bench-top versions of large and expensive equipment such as flow cytometry, or novel ones that exploit physical phenomena on the micron scale, such as dielectrophoresis for cell analysis.
In Microengineering in Biotechnology, experts in the field contribute chapters aimed at instilling in the reader a working understanding of the methods underlying microengineering and the means by which such methods can be used for a range of analytical techniques. It describes the methods by which microengineered devices can be built to perform a number of applications and considers how the field may progress by examining some more complex lab on a chip devices which have great potential in the advancement of the way in which molecular biology is performed. As a volume in the highly successful Methods in Molecular Biology(TM) series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.
Cutting-edge yet easy-to-use, Microengineering in Biotechnology serves as a reference guide for practical microengineering techniques and as a route into the development of new devices for biological applications in order to strengthen the promising union of molecular and cellular biology with microelectronics.
Discover new ways of screening; everything from molecular fractionation to label-free electrophysiology of suspended cells, from neural interfaces to laboratories on a chip
Provides a comprehensive description of microengineering fabrication techniques in simple terms - an ideal resource for anyone, from beginner to expert
Covers a wide range of assay formats and technologies, from well-established to experimental
Presents a modular approach to experimental design, covering screening modalities, detection technologies, and approaches to data analysis
Includes in-depth analyses of how microengineering can be applied both in vitro and in vivo