Part I. Gasotransmitters: Past, Present, and Futuren n The Evolution of Gasotransmitter Biology and Medicine: From Atmospheric Toxic Gases to Endogenous Gaseous Signaling Moleculesn Rui Wangn n Interactions Between Gasotransmittersn Ray J. Carson, Gunter Seyffarth, Rubina Mian, and Helen Maddockn n Part II. The Emergence of the First Gasotransmitter: Nitric Oxiden n Nitric Oxide: Synthesis and Metabolism, Tissue Stores, and the Relationship of Endothelium-Derived Nitric Oxide to Endothelium-Dependent Hyperpolarizationn Chris R. Triggle, Hong Ding, Ella S. M. Ng, and Anthie Ellisn n Chemical Interaction of Nitric Oxide With Protein Thiols: S-Nitrosylation Signalingn Allan Doctor and Benjamin M. Gastonn n Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels: Their Different Properties But Analogous Effects on Cellular Protectionn Shoji Sanada, Jiyoong Kim, and Masafumi Kitakazen n Interactions of Nitric Oxide and Related Radical Species With KCa Channelsn Yanping Liu and David D. Guttermann n Nitric Oxide and Voltage-Gated Ca2+ Channelsn Claudio Grassi, Marcello D'Ascenzo, and Gian Battista Azzenan n Interactions of Nitric Oxide and Cardiac Ion Channelsn Zhao Zhang, Kathryn A. Glatter, and Nipavan Chiamvimonvatn n S-Nitrosylation of Cyclic Nucleotide-Gated Channelsn Marie-Christine Broilletn n Part III. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmittern n Synthesis and Metabolism of Carbon Monoxiden Stefan W. Ryter and Augustine M. K. Choin n Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cellsn Rui Wangn n Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cellsn Rui Wangn n The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channelsn Lingyun Wun n Carbon Monoxide and Signal Transduction Pathwaysn Patty J. Lee and Leo E. Otterbeinn n Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cellsn Eric Dubuis, Prem Kumar, Pierre Bonnet, and Christophe Vandiern n Part IV. Gas of the Rotten Egg: Hydrogen Sulfide as Another Gasotransmittern n Hydrogen Sulfide Production and Metabolism in Mammalian Tissuesn Kenneth N. Maclean and Jan P. Krausn n Toxicological and Environmental Impacts of Hydrogen Sulfiden Sheldon H. Rothn n Hydrogen Sulfide and the Regulation of Neuronal Activitiesn Hideo Kimuran n The Role of Hydrogen Sulfide as an Endogenous Vasorelaxant Factorn Rui Wang, Youqin Cheng, and Lingyun Wun n Hydrogen Sulfide and Visceral Smooth Muscle Contractilityn Philip K. Mooren n Interaction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle Cellsn Rui Wangn n Part V. Gasotransmitters, Other Gaseous Molecules, and Cell Metabolismn n Gasotransmitters as a Novel Class of Metabolic Regulators: Nitric Oxide, Carbon Monoxide, and Nitrous Oxiden Misato Kashiban n Index
Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels.