Structure and Function of the Immune System in Vertebratesn n Ontogeny and the Development of Cells Mediating Innate and Adaptive Immunityn n Phenotypic Characteristics of Neonatal B Cellsn n Molecular Characteristics of Neonatal B-Cell Repertoiren n Genetically Programmed Temporal Ordered Activation of Neonatal B-Cell Clonesn n Antibody Response in Fetuses and Newbornsn n Effect of Maternal Antibodies on Neonatal B-Cell Responsen n Neonatal Autoimmune Diseases Caused by Maternal Pathogenic Autoantibodiesn n Phenotypic Characteristics of Neonatal T Cellsn n Expression of MHC Molecules in Neonates. Neonatal Cytokine Networkn n Cell-Mediated Immune Responses in Neonates. Fetal and Neonatal Tolerancen n Development of Efficient Prophylactic Vaccines and Theracines for Newborns and Infantsn n Referencesn n Index.
A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.
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