Part I. Platelet Physiologyn n Platelet Physiologyn Martin Quinnn n Platelet Integrins and Signalingn Karlheinz Petern n Platelet Adhesionn Brian Savage and Zaverio M. Ruggerin n Structure-Function of the Platelet Cytoskeletonn Elaine L. Bearern n Platelets and Inflammationn Meinrad Gawazn n Platelet Signal-Dependent Protein Synthesisn Stephan Lindemann, Thomas M. McIntyre, Stephen M. Prescott, Guy A. Zimmerman, and Andrew S. Weyrichn n Phosphoproteomics of Human Plateletsn Katrin Marcus and Helmut E. Meyern n Part II. Assessing Platelet Functionn n Platelet Function Studiesn Dermot Coxn n Platelet Function Under Flown José A. López, Ian del Conde, and Jing-Fei Dongn n Pharmacodynamics of GPIIb-IIIa Receptor Blockaden Lisa K. Jennings and Melanie M. Whiten n Prostanoid Generation in Platelet Function: Assessment and Clinical Relevancen Bianca Rocca and Carlo Patronon n Platelets and Prothrombinn Michael Kalafatis, Emil Negrescu, Tatiana Byzova, and Edward F. Plown n Markers of Platelet Activation and Granule Secretionn Alan D. Michelson and Mark I. Furmann n Genomic and Proteomic Analysis of Platelets: Clinical Applicationsn Andrew Maree and James McRedmondn n Part III. Clinical Applicationsn n Antiplatelet Agentsn Jacqueline Saw and David J. Moliternon n Assessing Platelet Function in Clinical Trialsn Neal Kleimann n Index
A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.