Part I. Theory and Technical Conceptn n Computational Biology: Are We There Yet?n Gary Peltzn n Statistical Theory in QTL Mappingn Benjamin Yakir, Anne Pisanté, and Ariel Darvasin n Haplotype-Based Computational Genetic Analysis in Micen Jianmei Wang and Gary Peltzn n Haplotype Structure of the Mouse Genomen Jianmei Wang, Guochun Liao, Janet Cheng, Anh Nguyen, Jingshu Guo, Christopher Chou, Steven Hu, Sharon Jiang, John Allard, Steve Shafer, Anne Puech, John D. McPherson, Dorothee Foernzler, Gary Peltz, and Jonathan Usukan n SNP Discovery and Genotyping: Methods and Applicationsn Jun Wang, Dee Aud, Soren Germer, and Russell Higuchin n Part II. Selected Examples: Murine Models of Human Diseasen n Genetic and Genomic Approaches to Complex Lung Diseases Using Mouse Modelsn Michael J. Holtzman, Edy Y. Kim, and Jeffrey D. Mortonn n Murine Models of Osteoporosisn Robert F. Kleinn n Murine Models of Substance and Alcohol Dependence: Unraveling Genetic Complexitiesn Kim Cronise and John C. Crabben n Murine Models of Alcoholism: From QTL to Genen Chris Downing, Beth Bennett, and Thomas E. Johnsonn n Part III. Selected Examples: The Genetic Basis for Human Diseasen n HLA Polymorphism and Disease Susceptibilityn Henry A. Erlichn n Asthma Genetics: A Case Studyn William Cooksonn n Index
Ultimately, the quality of the tools available for genetic analysis and experimental disease models will be assessed on the basis of whether they provide new information that generates novel treatments for human disease. In addition, the time frame in which genetic discoveries impact clinical practice is also an important dimension of how society assesses the results of the significant public financial investment in genetic research. Because of the investment and the increased expectation that new tre- ments will be found for common diseases, allowing decades to pass before basic discoveries are made and translated into new therapies is no longer acceptable. Computational Genetics and Genomics: Tools for Understanding Disease provides an overview and assessment of currently available and developing tools for genetic analysis. It is hoped that these new tools can be used to identify the genetic basis for susceptibility to disease. Although this very broad topic is addressed in many other books and journal articles, Computational Genetics and Genomics: Tools for Understanding Disease focuses on methods used for analyzing mouse genetic models of biomedically - portant traits. This volume aims to demonstrate that commonly used inbred mouse strains can be used to model virtually all human disea- related traits. Importantly, recently developed computational tools will enable the genetic basis for differences in disease-related traits to be rapidly identified using these inbred mouse strains. On average, a decade is required to carry out the development process required to demonstrate that a new disease treatment is beneficial.
Well-recognized computational geneticists review and assess both currently available and developing tools for the rapid identification of the genetic basis for susceptibility to disease. The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiologic or pathologic responses among inbred mouse strains, thus facilitating more rapid genetic discovery. The focus is on the haplotype-based computational genetic analysis method and its application to inbred mouse strains. Reviewing murine models of asthma, lung disease, osteoporosis, and substance abuse, the contributors provide an overview of available mouse models, what has been learned from them, and which new models must be developed to advance our understanding of these diseases.