Neuroendocrine Control of Testicular Functionn Stephen J. Winters and Alan C. Dalkinn n Leydig Cell Function in Mann Qiang Dong and Matthew P. Hardyn n Spermatogenesis and Its Regulation in Higher Primatesn Gary R. Marshalln n Normal and Delayed Pubertyn Leo Dunkeln n Congenital Hypogonadotropic Hypogonadism: Clinical Features and Pathophysiologyn William F. Crowley and Nelly Pitteloudn n Male Hypogonadism Resulting From Mutations in the Genes for the Gonadotropin Subunits and Their Receptorsn Ilpo T. Huhtaniemin n Hypogonadism in Males With Congenital Adrenal Hyperplasian Barto J. Otten, Nike M. M. L. Stikkelbroeck, and Ad R. M. M. Hermusn n Male Hypogonadism Resulting From Disorders of the Pituitary and Suprasellar Regionn Annamaria Colao, Giovanni Vitale, Michele De Rosa, and Gaetano Lombardin n Klinefelter's Syndromen John K. Amory and William J. Bremnern n Cryptorchidismn Peter A. Lee, Barry A. Kogan, and Michael T. Coughlinn n Hypogonadism in Men With HIV-AIDSn Shalender Bhasinn n Hypogonadism in Men With Chronic Renal Failuren Peter Y. Liu and David J. Handelsmann n Male Hypogonadism Resulting From Cancer and Cancer Treatmentsn Simon J. Howell and Stephen M. Shaletn n An Ensemble Perspective of Aging-Related Hypoandrogenemia in Menn Johannes D. Veldhuis, Ali Iranmanesh, and Daniel Keenann n Environmental Causes of Testicular Dysfunctionn Richard M. Sharpen n Exercise and Male Hypogonadism: Testosterone, the Hypothalamic-Pituitary-Testicular Axis, and Physical Exercisen Anthony C. Hackney and Jennifer Dobridgen n Testosterone, SHBG, and the Metabolic Cardiovascular Syndromen Joseph M. Zmuda and Stephen J. Wintersn n Androgen Replacement Therapy in Hypogonadal Menn Christina Wang and Ronald S. Swerdloffn n Stimulation of Spermatogenesis in Hypogonadotropic Menn Marion Depenbusch and Eberhard Nieschlagn n Index
Recent advances in cellular and molecular biology have markedly increased our understanding of normal and abnormal hypothalamic-pituitary-testicular function. Like other volumes in the Contemporary Endocrinology series, the goal of Male Hy- gonadism: Basic, Clinical, and Therapeutic Principles is to link current knowledge of basic biology to the practice of medicine. The development of new methods for testost- one replacement has substantially increased the number of men who are seeking to determine whether they are hypogonadal, and who are using testosterone replacement therapy, thus mandating a broader understanding of testosterone deficiency. The chapters of this book were contributed by authors from around the world, and from various scientific and clinical disciplines, who have devoted their careers to the study of the physiology and pathophysiology of the male. Thus, this comprehensive and focused volume is intended for a wide audience encompassing both basic scientists and practicing clinicians. Its scope will provide a wealth of information for students and fellows as well.