Part I. Pathophysiologyn n The Spectrum of Myocardial Ischemia: The Paradigm of Acute Coronary Syndromesn Christopher P. Cannon and Eugene Braunwaldn n Linking Biochemistry, Vascular Biology, and Clinical Events in Acute Coronary Syndromesn Richard C. Becker and Annemarie Armanin n Triggers of Acute Coronary Syndromesn Peter M. Sapin and James E. Mullern n Insights into the Pathophysiology of Acute Ischemia Syndromes Using the TIMI Flow Grade, TIMI Frame Count, and TIMI Myocardial Perfusion Graden C. Michael Gibson, Sabina A. Murphy, and Jeffrey J. Popman n Part II. Diagnosisn n Emergency Department Presentations of Acute Cardiac Ischemian J. Hector Pope and Harry P. Selkern n Early Identification and Treatment of Patients with Acute Coronary Syndromesn Mary M. Hand and Costas T. Lambrewn n Serum Markers for Diagnosis and Risk Stratification in Acute Coronary Syndromesn L. Kristin Newby, W. Brian Gibler, Robert H. Christenson, and E. Magnus Ohmann n Technologies to Diagnose Acute Ischemian Robert J. Zalenski, Joseph Lau, and Harry P. Selkern n Part III. ST-Segment Elevation Myocardial Infarctionn n Thrombolytic Therapyn Jeffrey L. Anderson and James S. Zebrackn n Primary Angioplastyn Sorin J. Brener and Eric J. Topoln n Expanding the Access to Percutaneous Coronary Intervention for Patients Admitted to Community Hospitalsn Thomas P. Wharton, Jr. and Nancy Sinclair McNamaran n Antiplatelet and Anticoagulant Therapyn Marc S. Sabatine and Ik-Kyung Jangn n b-Adrenergic Blockers, Calcium Channel Blockers, and Nitratesn Yerem Yeghiazarians and Peter H. Stonen n Angiotensin Converting Enzyme Inhibitors After and During Acute Coronary Syndromes, and, in Particular, Myocardial Infarctionn Rodolfo Carrillo-Jimenez, Charles H. Hennekens, and Gervasio A. Lamasn n Risk Stratification: Exercise Testing, Imaging, and Cardiac Catheterizationn Sanjeev Puri, Hani A. Razek, and Bernard R. Chaitmann n Part IV. Non-ST-Segment Elevation Myocardial Infarctionn n Anticoagulant Therapies, Marc Cohen. Antiplatelet Therapyn Ian Conde-Pozzi and Neal S. Kleimann n Thrombolytics and Invasive vs Conservative Strategies in Unstable Anginan Ali Moustapha and H. Vernon Andersonn n Current Device Strategies in the Management of Acute Coronary Syndromesn Kanwar P. Singh and C. Michael Gibsonn n Part V. Special Aspects of Acute Coronary Syndromesn n Women and Acute Coronary Syndromesn Jane A. Leopold and Alice K. Jacobsn n The Modern Strategy for Cardiogenic Shockn Gary E. Lane and David R. Holmes, Jr.n n Myocardial Infarction in the Younger Patientn James C. Fang and Jorge Plutzkyn n Cholesterol Loweringn Terje R. Pedersen and Serena Tonstadn n 'Secondary Prevention' of Myocardial Infarctionn Jorge Plutzky and Roger S. Blumenthaln n Cost and Cost-Effectiveness in Acute Coronary Syndromesn William S. Weintraubn n Smoking Cessationn Beth C. Bock and Bruce Beckern n Critical Pathways for Acute Coronary Syndromesn Christopher P. Cannon and Patrick T. O'Garan n Index
In this second edition of his highly acclaimed book, Christopher P. Cannon, MD, and a team of preeminent clinical investigators have thoroughly revised and expanded every chapter to reflect the recent explosion of clinical trials on the management of acute coronary syndromes (ACS). This includes: the newer tests, such as C reactive protein; a multimarker approach to diagnosis and risk stratification; new antiplatelet agents; and combinations of thrombolytic-antithrombotic regimens. Also discussed are the latest developments in interventional cardiology, the use of cost-effectiveness in clinical trials to choose appropriate therapies, and the employment of critical pathways analysis to improve compliance with evidence-based medicine and guideline recommendations.