Part I. Introductionn n Introduction: Present and Potential Impact of Expression Profiling Studies of Human Tumorsn Marc Ladanyi and William L. Geraldn n Part II. Technical Aspectsn n cDNA Microarraysn Paul S. Meltzern n Oligonucleotide Microarraysn Marina Chicurel and Dennise Dalma-Weiszhauszn n Serial Analysis of Gene Expression (SAGE) in Cancer Researchn C. Marcelo Aldazn n Tissue Arraysn Cyrus V. Hedvatn n Microarray Data Analysis: Cancer Genomics and Molecular Pattern Recognitionn Pablo Tamayo and Sridhar Ramaswamyn n The Role of Tumor Banking and Related Informaticsn Stephen J. Qualman, Jay Bowen, Sandra Brewer-Swartz, and Mary Francen n Part III. Applicationsn n Characterization of Gene Expression Patterns for Classification of Breast Carcinomasn Irene L. Andrulis, Nalan Gokgoz, and Shelley B. Bulln n Microarray Analysis of Colorectal Cancern Daniel A. Notterman, Carrie J. Shawber, and Wei Liun n Gene Expression Analysis of Prostate Carcinoman William L. Geraldn n Classification of Human Lung Carcinomas by mRNA Expression Profilingn Arindam Bhattacharjee and Matthew Meyersonn n Molecular Profiling of Bladder Cancer Using High-Throughput DNA Microarraysn Marta Sánchez-Carbayo and Carlos Cordon-Cardon n Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implicationsn Masayuki Takahashi and Bin Tean Tehn n Expression Profiling of Pancreatic Ductal Adenocarcinoman Christine A. Iacobuzio-Donahue and Ralph H. Hrubann n Gene Expression in Ovarian Carcinoman Garret M. Hamptonn n Classification of Pediatric Tumors Using DNA Microarraysn Javed Khan and Marc Ladanyin n Transcriptomes of Soft Tissue Tumors: Pathologic and Clinical Implicationsn Sabine C. Linn, Rob B. West, and Matt van de Rijnn n Gene Expression Profiling inLymphoid Malignanciesn Wing C. Chan and Louis M. Staudtn n Gene Expression Profiling of Brain Tumorsn Meena K. Tanwar and Eric C. Hollandn n Expression Profiling of Bone Tumorsn Deborah Schofield, Daniel Wai, and Timothy J. Trichen n Index
A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.