Section I: Plant Immunityn Section Editor: Frederick M. Ausubeln n Introductionn Frederick M. Ausubeln n Pathogen Recognition and Signal Transduction in Plant Immunityn Jonathan Cohn and Gregory B. Martinn n Plant Disease Resistance Genesn Jeffrey G. Ellis and David A. Jonesn n Nonhost Resistance in Plants to Microbial Pathogensn Michèle C. Heathn n Section II: Invertebrate Host Defense Immunityn Section Editor: Jean-Marc Reichhartn n Introductionn Jean-Marc Reichhartn n Regulatory Co-options in the Evolution of Deuterostome Immune Systemsn Ellen V. Rothenberg and Eric H. Davidsonn n Antimicrobial Peptides in Insect Immunityn Philippe Bulet, Maurice Charlet, and Charles Hetrun n Innate Immunity in the Horseshoe Crabn Shun-ichiro Kawabata, Tsukasa Osaki, and Sadaaki Iwanagan n Pattern Recognition Receptors in Drosophilan Mika Rämet, Alan Pearson, Kati Baksa, and Asha Harikrishnann n Humoral and Cellular Responses in Drosophila Innate Immunityn Julien Royet, Marie Meister, and Dominique Ferrandonn n Thioester-Containing Proteins of Protostomesn Elena A. Levashina, Stéphanie Blandin, Luis F. Moita, Marie Lagueux, and Fotis C. Kafatosn n Section III: Mammalian Host Defenses: Pattern Recognition Receptorsn Section Editor: Siamon Gordonn n Introductionn Siamon Gordonn n Toll-Like Receptorsn Tsuneyasu Kaisho and Shizuo Akiran n The Macrophage Mannose Receptor and Innate Immunityn Thiruvamoor P. Ramkumar, Djilali Hammache, and Philip D. Stahln n Diverse Roles of Lung Collectins in Pulmonary Innate Immunityn Erika C. Crouch and Jeffrey A. Whitsettn n Structures of Complement Control Proteinsn Thilo Stehle and Mykol Larvien n Lipopolysaccharide-Binding Protein and CD14n Peter S. Tobiasn n Section IV: Mammalian Host Defenses: LinksBetween Innate and Adaptive Immunityn Section Editor: Steven L. Kunkeln n Introductionn Steven L. Kunkeln n The Role of Chemokines in Linking Innate and Adaptive Immunityn Cory M. Hogaboam and Steven L. Kunkeln n Antimicrobial Peptidesn Tomas Ganz and Robert I. Lehrern n The Role of Complement in Innate and Adaptive Immunityn Mihaela Gadjeva, Admar Verschoor, and Michael C. Carrolln n The Role of Natural Killer Cells in Innate Immunity to Infectionn Wayne M. Yokoyaman n Innate Immune Signaling During Phagocytosisn David M. Underhilln n The Role of Mast Cells in Innate Immunityn Joshua A. Boyce and K. Frank Austenn n CD1-Restricted T-Cellsn D. Branch Moodyn n Index
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to playa key role in stimulating the subsequent clonal response of adaptive immunity. Recent exciting information has determined that the templates that are laid down in primitive life forms, like flowering plants and insects, form the basic principles of first line host defense that are conserved in mammalian systems. The next frontier in the field is to understand the dynamic adaptive changes that occur as a result of the inter play between host defenses and infectious agents. One emerging theme is that microorganisms are constantly seeking ways to co-opt host defenses. On the other hand, host defense to infection is mediated by the coordinate action of pattern recognition molecules and receptors that, in mammals, are important and probably necessary antecedents to the development of an adaptive immune response. Innate Immunity aims to explore the intersection between host pathogen interactions across an evolutionary spectrum that will inform our understanding of the dynamic interplay between infectious agents and host defense in man.