Chapter 1. Introduction.- Chapter 2. Modeling of Signal Transduction by The Quorum-Sensing Pathway in the Vibrios.- Chapter 3. Stochastic Effects in Quorum Sensing.- Chapter 4. Spatial Structure of Microbes in Nature and the Biophysics of Cell-Cell Communication.- Chapter 5. Functionality of Autoinducer Systems in Complex Environments.- Chapter 6. Localization of Quorum Sensing by Extracellular Polymeric Substances (EPS): Considerations of in Situ Signaling.- Chapter 7. Swimming in Information? Physics Limits to Learning by Quorum Sensing.- Chapter 8. Interplay Between Sibling Bacterial Colonies.- Chapter 9. Mathematical Insights Into the Role of Feedback in Quorum-Sensing Architectures.- Chapter 10. The Role of Biosurfactants in Bacterial Systems.- Chapter 11. Ecology of a Simple Synthetic Biofilm.- Chapter 12. Engineering Cell-to-Cell Communication To Explore Fundamental Questions in Ecology and Evolution.
Quorum sensing (QS) describes a chemical communication behavior that is nearly universal among bacteria. Individual cells release a diffusible small molecule (an autoinducer) into their environment. A high concentration of this autoinducer serves as a signal of high population density, triggering new patterns of gene expression throughout the population. However QS is often much more complex than this simple census-taking behavior. Many QS bacteria produce and detect multiple autoinducers, which generate quorum signal cross talk with each other and with other bacterial species. QS gene regulatory networks respond to a range of physiological and environmental inputs in addition to autoinducer signals. While a host of individual QS systems have been characterized in great molecular and chemical detail, quorum communication raises many fundamental quantitative problems which are increasingly attracting the attention of physical scientists and mathematicians. Key questions include: What kinds of information can a bacterium gather about its environment through QS? What physical principles ultimately constrain the efficacy of diffusion-based communication? How do QS regulatory networks maximize information throughput while minimizing undesirable noise and cross talk? How does QS function in complex, spatially structured environments such as biofilms? Previous books and reviews have focused on the microbiology and biochemistry of QS. With contributions by leading scientists and mathematicians working in the field of physical biology, this volume examines the interplay of diffusion and signaling, collective and coupled dynamics of gene regulation, and spatiotemporal QS phenomena. Chapters will describe experimental studies of QS in natural and engineered or microfabricated bacterial environments, as well as modeling of QS on length scales spanning from the molecular to macroscopic. The book aims to educate physical scientists and quantitative-oriented biologists o
Analyzes bacterial quorum sensing from a physical and mathematical perspective
Explores the role of spatiotemporal diffusion, regulatory dynamics, stochasticity and information in quorum communication
Includes contributions from leading experimentalists, theoreticians, engineers and modelers
Takes a physical science and engineering approach to the subject, but will appeal to anyone with a background in physical biology