Über den Autor
Prof. Perumana R. Sudhakaran is currently the Dean of the School of Biological Sciences and Professor of Biochemistry, Central University of Kerala, Kasargod, India. His major area of research is cell extracellular matrix interaction and cell signaling.
Prof. Avadesha Surolia is currently the Director of the National Institute of Immunology, New Delhi and a Professor of Molecular Biophysics at the Indian Institute of Science, Bangalore, India. His major areas of research include structure and function of lectins, orientation and dynamics of cell surface carbohydrate receptors, protein folding and quality control in the endoplasmic reticulum.
Preface Chapter 1. Glycomics: An overview of the complex glycocode Chapter 2. Structural Glycomic Approaches to Molecular Recognition Events on Cell Surfaces Chapter 3. Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis Chapter 4. Chondroitin sulfate-specific novel hydrolase in human Chapter 5. Identification of endothelial cell surface carbohydrate-binding receptors by carbohydrate ligand mimicry peptides. Chapter 6. Lysosomal enzyme sorting receptors - Where did they first appear in the animal kingdom? Chapter 7. Endoplasmic reticulum targeted Bcl-2 inhibitable mitochondrial fragmentation initiates ER stress induced cell death Chapter 8. Interactions between Caveolin-1and Sphingolipids and their functional relevance Chapter 9. Cell Membrane Repair Pathway Involves Sensing of Dynamics of Caveolae and Caspase-1 Chapter 10. Angiogenic Response of Endothelial Cells to Fibronectin Chapter 11. Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models Chapter 12. Advanced Fret Methodologies: Protein Lipid Selectivity detection and Quantification Chapter 13. Mechanism of GPCR-directed Autoantibodies in Diseases Chapter 14. Role of Membrane Cholesterol in Leishmanial Infection Chapter 15. How Intact is the Basement Membrane? Role of MMPs Chapter 16. Apoptosis of Breast Cancer Cells: IX. Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery Chapter 17. Altered expression of sialidases in human cancer Chapter 18. Poly-ADP-ribosylation of vascular endothelial growth factor and its implications on angiogenesis. Chapter 19. Sphingolipid Binding Domain in the Serotonin1A Receptor Chapter 20. Withanolide-D, carrying the baton of Indian Rasayana herb as a lead candidate of anti-leukemic agent in modern medicine Chapter 21. Engineered glucose to generate a spectroscopic probe for studying carbohydrate biology Chapter 22. Changes in sialic acid content of jelly coat in pesticide exposed frog eggs and its influence on fertilization
Cell surface molecules are critically important in regulating cell structure and function. Recent advances on the functional role of cell surface molecules, particularly glycoconjugates are presented in this book. Comprising of 22 chapters from the 2011 International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules, it covers topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell-matrix interaction.
Comprehensive critical reviews and original research papers from the 2011 Proceedings of the International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules Provides an in-depth analysis of data on cell surface macromolecules in cellular function Covers topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell-matrix interaction