1. Historical perspectives in understanding traumatic brain injury and in situating disruption in CBF in the pathotrajectory of head traumaChristopher Betrus, Christian Kreipke2. Situating Cerebral Blood Flow in the Pathotrajectory of Head TraumaJustin Graves, Christopher Betrus, Jose A. Rafols 3. Modeling of traumatic brain injury and its implications in studying the pathology of repeated mild impacts to the headMichael J. Kane, Mariana Angoa Pérez, Denise I. Briggs, David C. Viano, Christian W. Kreipke, Donald M. Kuhn4. The presence of venous damage and microbleeds in traumatic brain injury and the potential future role of angiographic and perfusion magnetic resonance imagingE. M. Haacke, Waqar Raza, Wu Bo, Zhifeng Kou 5. Situating the Endothelin System in the pathotrajectory of TBI-induced changes in haemodynamicsAnthony Kropinski, Paula Dore-Duffy, Christian Kreipke6. Age and Sex Differences in Cerebral Blood Flow and Autoregulation after Pediatric Traumatic Brain InjuryWilliam M. Armstead, Monica S. Vavilala7. New Frontiers in Clinical Trials Aimed at Improving Outcome Following Traumatic Brain InjuryChristian W. Kreipke, Anthony Kropinski, Justin Graves, David Tiesma, Michael Kaufman, Steven Schafer, William Armstead, Paula Dore-Duffy, Donald Kuhn
Written to satisfy a wide audience, from basic scientist to clinical researcher, this volume explores such varied concepts as: the influence of CBF in the pathotrajectory of TBI, modeling TBI as a means to understand underlying pathological states associated with brain injury victims, disrupted vasculature following head trauma and advanced imaging techniques, vasoreactive substances underlying disrupted blood flow, the role of age and sex on injury outcome, and the latest pre-clinical rationale for focusing on CBF and strategies to improve blood flow as a means to improve outcome in patients suffering the effects of TBI.
Represents the first concise compilation of information related to blood flow and head trauma Showcases the most timely and cutting-edge advances in understanding both basic science and medical data pertaining to TBI Provides a unique translational quality by containing both mechanistic and clinical observational information