Preface Part I Methodologies 1. Tools to study signaling Part II Normal Signaling Processes 2. Cell-cycle Signaling, Epigenetic and Nuclear Function 3. Signaling in the Endothelium 4. Rapid Signaling Pathways 5. Growth Factors Signaling Pathways 6. Ion Channels Signaling 7. Lipids Signaling Part III Mitochondria 8. Heart Mitochondria: A Receiver and Integrator of Signals Part IV Pediatric Cardiology 9. Signaling Pathways in Cardiovascular Development 10. Signaling in Congenital Heart Disease Part V Aging 11. Signaling in the Aging Heart Part VI Signaling in Cardiovascular Disease 12. Signaling in Endomyocarditis. 13. Signaling Pathways in Hypertension 14. Gene Expression and Signaling Pathways in Myocardial Ischemia 15. Signaling in Hypertrophy and Heart Failure 16. Signaling in Diabetes and Metabolic Syndrome 17. Dysrhythmias/Channelopathies and Signaling Pathways 18. Signaling in Atherosclerosis Part VII Targeting Signaling in Cardiovascular Medicine. 19. Stem Cells Signaling Pathways 20. Cardioprotection and Signaling Pathways 21. Targeting Specific Pathways Part VIII Looking to the Future 22. Future Frontiers in Cardiovascular Signaling. Glossary
Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact.
This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.
Provides clear explanations of the complex mechanisms of signal transduction in the human heart Blends emerging discoveries in basic research with practical clinical applications Presents a consistent approach to the subject matter Reflects current post-genomic thinking, introduces new ideas and outlines future directions