Chapter 1- Overview of hedgehog signaling pathwayChi-chung Hui and Jin Jiang Chapter 2- Regulation of Hh morphogene gradientG. D'Angelo, F. Wendler, K. Ayers and P.P. Thérond Chapter 3- Smoothened Signaling through a G-protein Effector NetworkDavid J. Robbins and Stacey K. Ogden Chapter 4- Kinases and phosphatases in hedgehog signalingJianhang Jia Chapter 5- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic CancerXiaodong Cheng Chapter 6- Crosstalks between PKC and hedgehog signalingJing Li and Mark Evers Chapter 7- Activation of Hh signaling in human cancerJingwu Xie and Ervin Epstein Chapter 8- Hedgehog signaling in pediatric brain tumorsJoon Won Yoon, Ph.D., Jason Fangusaro, M.D., Philip Iannaccone, M.D., Ph.D., and David Walterhouse, M.D. Chapter 9- Hedgehog Signaling in Mammary Gland Development and Breast CancerAdriana P. Visbal and Michael T. Lewis Chapter 10- Hedgehog signaling and cancer therapeutic resistance K.S. Clifford Chao and Yu-Jen Chen Chapter 11- Small-molecule Inhibitors of the Hedgehog PathwayAri J. Firestone and James K. Chen Chapter 12- Cyclopamine and its derivatives for cancer therapeuticsMartin Tremblay and Karen McGovern
Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Presents up-to-date information in this exciting research areaSummarizes major advances made on hedgehog signaling mechanisms, activation of the pathway in various human cancer typesHighlights current challenges in our efforts to translate the basic biology into clinicProvides insightful views suitable for graduate, undergraduate, and medical students, basic and clinical scientists, cancer patients as well as the general public