Chapter 1 Bovine Spongiform EncephalopathyGianluigi Zanusso, Salvatore MonacoChapter 2 Classical and Atypical Scrapie in Sheep and GoatsChristine Fast, Martin H. GroschupChapter 3 Chronic wasting disease and the development of research modelsGlenn TellingChapter 4 Sporadic Human Prion DiseasePierluigi GambettiChapter 5 Environmentally-acquired Transmissible Spongiform EncephalopathyPaul BrownChapter 6 Prions in the EnvironmentShannon L. Bartelt-Hunt, Jason C. Bartz, Samuel E. SaundersChapter 7 The Spectrum of Tau Pathology in Human Prion DiseaseGabor G. Kovacs, Herbert BudkaChapter 8 Risk of Transmission of Creutzfeldt-Jakob Disease by Blood TransfusionAlexander H. Peden, Mark W. Head, James W. IronsideChapter 9 Species Barriers in Prion DiseaseSuzette A. PriolaChapter 10 Transgenic Mice ModellingAbigail B. Diack, Rona Wilson, Enrico Cancellotti, Barry Bradford, Matthew Bishop, Jean C. MansonChapter 11 Prion Transmission Studies in Transgenic MiceQingzhong Kong Chapter 12 Alternative Models of Prion DiseasesPedro Fernandez-Funez, Edward Málaga-Trillo, Diego E. Rincon-LimasChapter 13 Diagnosis of Prion Disease: Conventional ApproachesInga Zerr, Joanna Gawinecka, Katharina Stoeck, Maren BreithauptChapter 14 Quaking-induced Conversion (QuIC) Assays for the Detection and Diagnosis of Prion DiseasesJason M. Wilham, Christina D. Orrù, Sarah Vascellari, Andrew G. Hughson, Byron CaugheyChapter 15 The Tyr-Tyr-Arg Prion-Specific Epitope: Update and ContextT. Dean Airey, and Neil R. CashmanChapter 16 Overview on Treatment of Prion Diseases and Decontamination of PrionsRichard KnightChapter 17 ImmunomodulationThomas Wisniewski, Fernando Goñi
Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
Authored by a team of leading researchers and cliniciansUpdated knowledge and concepts on pathogenic prion proteins and prion diseasesPresent state-of the art findings and hypotheses beyond prions and prion diseases