Preface. Brief history of discovery and acknowledgments 1 The ECTO-NOX protein family2 Measurement of ECTO-NOX (ENOX) activities3 The constitutive ENOX1 (CNOX)4 Role in plasma membrane electron transport5 Role in the enlargement phase of cell growth6 Role as ultradian oscillators of the cells' biological clock7 Other potential functional roles of ENOX proteins8 ENOX2 (tNOX) and cancer9 Age-related ENOX proteins (arNOX)10 The auxin-stimulated ENOX and auxin-stimulation of plant growth11 Cancer therapeutic applications of ENOX2 proteins12 Diagnostic applicastions of -ENOX2 proteinsAppendix A Epilogue: Remaining challengesAppendix B Detailed description of 2-D gel electrophoresis western blot early detection protocol
This volume documents this unique family of cell surface proteins. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins have and continue to offer remarkable opportunities for research, commercial development and outside confirmation of therapeutic, diagnostic and new paradigms to help explain complex biological processes.
Explains the ligand basis of the cell?s biological clock
Provides an ENOX-based mechanism for how cells become larger (increase in size) that is both unique and well documented with applications not only to cancer and cancer therapy but for production in agriculture
First book to provide a complete overview of this unique family of proteins and their properties