Prefacenn1. History of ACC Research and Clinical Care n1.1. ACC - A 50 year retrospective viewn1.2. History of ACC Treatment - A Surgical Perspectivenn2. Epidemiology, Presentation and Diagnosisn2.1. Epidemiologyn2.2. Presentation and Diagnosisn2.3. Approach to the Adrenal incidentaloma nn3.0. Imaging n3.1. Anatomic imagingn3.2. Functional imagingnn4. Pathologyn4.1. ACC Histopathology n4.2. Molecular and Cellular Pathologynn5. Genetic & Molecular Aspects of ACCn5.1. Overview of the Genetics of ACC n5.2. Li Fraumeni Syndromen5.3. P53 Molecular Geneticsn5.4. Telomeres and ACCn5.5. Beckwith Wiedemann Syndromen5.6. Insulin-like growth Factorsn5.7. Wnt signalingnn6. Models of Adrenocortical Cancern6.1. Cellular origin and identity of ACC n6.2. Adrenocortical cell linesn6.3. Mouse Models of Adrenal Tumorigenesisnn7. Therapiesn7.1. Introductionn7.2. Mitotanen7.3. Cytotoxic Chemotherapyn7.4. Steroidogenesis and Therapy of Hormone Excessn7.5. Surgical therapyn7.6. Radiation Therapyn7.7. Surveillance and follow up of ACCnn8 Unique ACC Cohorts and Future Perspectivesn8.1.. Aldosterone producing ACCn8.2. Childhood ACCn8.3. Molecular Profiling of Adrenal Cancern8.4. Clinical Registries: Dutch and European experiencesn8.5. Emerging Strategies
We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practitioner and community of adrenal cancer scientists.
We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.
Motivated by the upcoming "First Annual International Adrenal Cancer Symposium: Clinical and Basic Science" to be held in the spring of 2008
Exciting combination of science, clinical care and resources for the physician and patient